PMID- 26754344
OWN - NLM
STAT- MEDLINE
DCOM- 20161005
LR  - 20221207
IS  - 1471-2261 (Electronic)
IS  - 1471-2261 (Linking)
VI  - 16
DP  - 2016 Jan 12
TI  - The association of reduced lung function with blood pressure variability in 
      African Americans: data from the Jackson Heart Study.
PG  - 6
LID - 10.1186/s12872-015-0182-2 [doi]
LID - 6
AB  - BACKGROUND: African Americans (AAs) have lower lung function, higher blood 
      pressure variability (BPV) and increased risk for hypertension and cardiovascular 
      disease (CVD) compared with whites. The mechanism through which reduced 
      lung-function is associated with increased CVD risk is unclear. METHODS: We 
      evaluated the association between percent predicted lung-function and 24-hour BPV 
      in 1008 AAs enrolled in the Jackson Heart Study who underwent ambulatory blood 
      pressure (BP) monitoring. Lung-function was assessed as forced expiratory volume 
      in one second (FEV1), forced vital capacity (FVC) and the ratio of FEV1-to-FVC 
      during a pulmonary function test using a dry rolling sealed spirometer and 
      grouped into gender-specific quartiles. The pairwise associations of these three 
      lung-function measures with two measures of 24-hour BPV, (1) day-night standard 
      deviation (SDdn) and (2) average real variability (ARV) were examined for 
      systolic BP (SBP) and, separately, diastolic BP (DBP). RESULTS: SDdn of SBP was 
      not associated with FEV1 (mean +/- standard deviation from lowest-to-highest 
      quartile: 9.5 +/- 2.5, 9.4 +/- 2.4, 9.1 +/- 2.3, 9.3 +/- 2.6; p-trend = 0.111). After age 
      and sex adjustment, the difference in SDdn of SBP was 0.0 (95% CI -0.4,0.4), -0.4 
      (95% CI -0.8,0.1) and -0.3 (95% CI -0.7,0.1) in the three progressively higher 
      versus lowest quartiles of FEV1 (p-trend = 0.041). Differences in SDdn of SBP 
      across FEV1 quartiles were not statistically significant after further 
      multivariable adjustment. After multivariable adjustment, no association was 
      present between FEV1 and ARV of SBP or SDdn and ARV of DBP or when evaluating the 
      association of FVC and FEV1-to-FVC with 24-hour BPV. CONCLUSION: Lung-function 
      was not associated with increased 24-hour BPV.
FAU - Booth, John N 3rd
AU  - Booth JN 3rd
AD  - University of Alabama at Birmingham, Birmingham, AL, USA.
FAU - Redmond, Nicole
AU  - Redmond N
AD  - University of Alabama at Birmingham, Birmingham, AL, USA.
FAU - Sims, Mario
AU  - Sims M
AD  - University of Mississippi Medical Center, Jackson, MS, USA.
FAU - Shimbo, Daichi
AU  - Shimbo D
AD  - Columbia University Medical Center, New York, NY, USA.
FAU - Muntner, Paul
AU  - Muntner P
AD  - University of Alabama at Birmingham, Birmingham, AL, USA. pmuntner@uab.edu.
AD  - Department of Epidemiology, University of Alabama at Birmingham, 1700 University 
      Boulevard, LHL 440, Birmingham, AL, 35294, USA. pmuntner@uab.edu.
LA  - eng
GR  - HHSN268201300049C/PHS HHS/United States
GR  - HHSN268201300048C/PHS HHS/United States
GR  - P60 MD002249/MD/NIMHD NIH HHS/United States
GR  - U54 MD008176/MD/NIMHD NIH HHS/United States
GR  - HHSN268201300047C/PHS HHS/United States
GR  - R01 HL117323-01/HL/NHLBI NIH HHS/United States
GR  - HHSN268201300048C/HL/NHLBI NIH HHS/United States
GR  - K12-HS023009/HS/AHRQ HHS/United States
GR  - K12 HS023009/HS/AHRQ HHS/United States
GR  - HHSN268201300049C/HL/NHLBI NIH HHS/United States
GR  - HHSN268201300050C/PHS HHS/United States
GR  - HHSN268201300046C/PHS HHS/United States
GR  - HHSN268201300047C/HL/NHLBI NIH HHS/United States
GR  - HHSN268201300050C/HL/NHLBI NIH HHS/United States
GR  - U54MD008176/MD/NIMHD NIH HHS/United States
GR  - P60MD002249/MD/NIMHD NIH HHS/United States
GR  - R01 HL117323/HL/NHLBI NIH HHS/United States
GR  - HHSN268201300046C/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20160112
PL  - England
TA  - BMC Cardiovasc Disord
JT  - BMC cardiovascular disorders
JID - 100968539
SB  - IM
MH  - *Black or African American
MH  - Aged
MH  - Blood Pressure/*physiology
MH  - Blood Pressure Monitoring, Ambulatory
MH  - Cardiovascular Diseases/epidemiology/physiopathology
MH  - Circadian Rhythm/physiology
MH  - Female
MH  - Forced Expiratory Volume
MH  - Humans
MH  - Hypertension/epidemiology/*physiopathology
MH  - Linear Models
MH  - Lung/physiology/*physiopathology
MH  - Lung Diseases/epidemiology/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Risk Factors
MH  - Smoking/epidemiology
MH  - Vital Capacity
PMC - PMC4709870
EDAT- 2016/01/13 06:00
MHDA- 2016/10/07 06:00
PMCR- 2016/01/12
CRDT- 2016/01/13 06:00
PHST- 2015/06/16 00:00 [received]
PHST- 2015/12/24 00:00 [accepted]
PHST- 2016/01/13 06:00 [entrez]
PHST- 2016/01/13 06:00 [pubmed]
PHST- 2016/10/07 06:00 [medline]
PHST- 2016/01/12 00:00 [pmc-release]
AID - 10.1186/s12872-015-0182-2 [pii]
AID - 182 [pii]
AID - 10.1186/s12872-015-0182-2 [doi]
PST - epublish
SO  - BMC Cardiovasc Disord. 2016 Jan 12;16:6. doi: 10.1186/s12872-015-0182-2.