PMID- 26755815
OWN - NLM
STAT- MEDLINE
DCOM- 20170109
LR  - 20170110
IS  - 1708-8267 (Electronic)
IS  - 1081-5589 (Linking)
VI  - 64
IP  - 1
DP  - 2016 Jan
TI  - Plasma thyroid hormone concentration is associated with hepatic triglyceride 
      content in patients with type 2 diabetes.
PG  - 63-8
LID - 10.1136/jim-2015-000019 [doi]
AB  - The underlying mechanisms responsible for the development and progression of 
      non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes 
      mellitus (T2DM) are unclear. Since the thyroid hormone regulates mitochondrial 
      function in the liver, we designed this study in order to establish the 
      association between plasma free T4 levels and hepatic triglyceride accumulation 
      and histological severity of liver disease in patients with T2DM and NAFLD. This 
      is a cross-sectional study including a total of 232 patients with T2DM. All 
      patients underwent a liver MR spectroscopy ((1)H-MRS) to quantify hepatic 
      triglyceride content, and an oral glucose tolerance test to estimate insulin 
      resistance. A liver biopsy was performed in patients with a diagnosis of NAFLD. 
      Patients were divided into 5 groups according to plasma free T4 quintiles. We 
      observed that decreasing free T4 levels were associated with an increasing 
      prevalence of NAFLD (from 55% if free T4>/=1.18 ng/dL to 80% if free T4<0.80 ng/dL, 
      p=0.016), and higher hepatic triglyceride accumulation by (1)H-MRS (p<0.001). 
      However, lower plasma free T4 levels were not significantly associated with more 
      insulin resistance or more severe liver histology (ie, inflammation, ballooning, 
      or fibrosis). Decreasing levels of plasma free T4 are associated with a higher 
      prevalence of NAFLD and increasing levels of hepatic triglyceride content in 
      patients with T2DM. These results suggest that thyroid hormone may play a role in 
      the regulation of hepatic steatosis and support the notion that hypothyroidism 
      may be associated with NAFLD. No NCT number required.
CI  - Copyright (c) 2016 American Federation for Medical Research.
FAU - Bril, Fernando
AU  - Bril F
AD  - Division of Endocrinology, Diabetes and Metabolism, University of Florida, 
      Gainesville, Florida, USA Malcom Randall VAMC, Gainesville, Florida, USA.
FAU - Kadiyala, Sushma
AU  - Kadiyala S
AD  - Division of Endocrinology, Diabetes and Metabolism, University of Florida, 
      Gainesville, Florida, USA Malcom Randall VAMC, Gainesville, Florida, USA.
FAU - Portillo Sanchez, Paola
AU  - Portillo Sanchez P
AD  - Division of Endocrinology, Diabetes and Metabolism, University of Florida, 
      Gainesville, Florida, USA Malcom Randall VAMC, Gainesville, Florida, USA.
FAU - Sunny, Nishanth E
AU  - Sunny NE
AD  - Division of Endocrinology, Diabetes and Metabolism, University of Florida, 
      Gainesville, Florida, USA.
FAU - Biernacki, Diane
AU  - Biernacki D
AD  - Division of Endocrinology, Diabetes and Metabolism, University of Florida, 
      Gainesville, Florida, USA Malcom Randall VAMC, Gainesville, Florida, USA.
FAU - Maximos, Maryann
AU  - Maximos M
AD  - Malcom Randall VAMC, Gainesville, Florida, USA Pediatric Gastroenterology, 
      Hepatology, and Nutrition, University of Florida, Gainesville, Florida, USA.
FAU - Kalavalapalli, Srilaxmi
AU  - Kalavalapalli S
AD  - Division of Endocrinology, Diabetes and Metabolism, University of Florida, 
      Gainesville, Florida, USA.
FAU - Lomonaco, Romina
AU  - Lomonaco R
AD  - Division of Endocrinology, Diabetes and Metabolism, University of Florida, 
      Gainesville, Florida, USA Malcom Randall VAMC, Gainesville, Florida, USA.
FAU - Suman, Amitabh
AU  - Suman A
AD  - Malcom Randall VAMC, Gainesville, Florida, USA Division of Gastroenterology, 
      Hepatology, and Nutrition, University of Florida, Gainesville, Florida, USA.
FAU - Cusi, Kenneth
AU  - Cusi K
AD  - Division of Endocrinology, Diabetes and Metabolism, University of Florida, 
      Gainesville, Florida, USA Malcom Randall VAMC, Gainesville, Florida, USA Division 
      of Diabetes, University of Texas Health Science Center at San Antonio, Texas, USA 
      Audie L. Murphy VAMC, San Antonio, Texas, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151216
PL  - England
TA  - J Investig Med
JT  - Journal of investigative medicine : the official publication of the American 
      Federation for Clinical Research
JID - 9501229
RN  - 0 (Thyroid Hormones)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Demography
MH  - Diabetes Mellitus, Type 2/*blood/complications
MH  - Female
MH  - Humans
MH  - Insulin Resistance
MH  - Liver/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Mitochondria/metabolism
MH  - Non-alcoholic Fatty Liver Disease/blood/complications/epidemiology
MH  - Prevalence
MH  - Severity of Illness Index
MH  - Thyroid Hormones/*blood
MH  - Triglycerides/*metabolism
OTO - NOTNLM
OT  - Diabetes Mellitus
OT  - Fatty Liver
OT  - Insulin
OT  - Obesity
OT  - Thyroid Diseases
EDAT- 2016/01/13 06:00
MHDA- 2017/01/10 06:00
CRDT- 2016/01/13 06:00
PHST- 2015/11/18 00:00 [accepted]
PHST- 2016/01/13 06:00 [entrez]
PHST- 2016/01/13 06:00 [pubmed]
PHST- 2017/01/10 06:00 [medline]
AID - jim-2015-000019 [pii]
AID - 10.1136/jim-2015-000019 [doi]
PST - ppublish
SO  - J Investig Med. 2016 Jan;64(1):63-8. doi: 10.1136/jim-2015-000019. Epub 2015 Dec 
      16.