PMID- 26756032
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160112
LR  - 20201001
IS  - 2234-1900 (Print)
IS  - 2234-3164 (Electronic)
IS  - 2234-1900 (Linking)
VI  - 33
IP  - 4
DP  - 2015 Dec
TI  - Feasibility and response of helical tomotherapy in patients with metastatic 
      colorectal cancer.
PG  - 320-7
LID - 10.3857/roj.2015.33.4.320 [doi]
AB  - PURPOSE: To investigate the treatment outcome and the toxicity of helical 
      tomotherapy (HT) in patients with metastatic colorectal cancer (mCRC). MATERIALS 
      AND METHODS: We retrospectively reviewed 18 patients with 31 lesions from mCRC 
      treated with HT between 2009 and 2013. The liver (9 lesions) and lymph nodes (9 
      lesions) were the most frequent sites. The planning target volume (PTV) ranged 
      from 12 to 1,110 mL (median, 114 mL). The total doses ranged from 30 to 70 Gy in 
      10-30 fractions. When the alpha/beta value for the tumor was assumed to be 10 Gy for the 
      biologically equivalent dose (BED), the total doses ranged from 39 to 119 Gy10 
      (median, 55 Gy10). Nineteen lesions were treated with concurrent chemotherapy 
      (CCRT). RESULTS: With a median follow-up time of 16 months, the median overall 
      survival for 18 patients was 33 months. Eight lesions (26%) achieved complete 
      response. The 1- and 3-year local progression free survival (LPFS) rates for 31 
      lesions were 45% and 34%, respectively. On univariate analysis, significant 
      parameters influencing LPFS rates were chemotherapy response before HT, aim of 
      HT, CCRT, PTV, BED, and adjuvant chemotherapy. On multivariate analysis, PTV </=113 
      mL and BED >48 Gy10 were associated with a statistically significant improvement 
      in LFPS. During HT, four patients experienced grade 3 hematologic toxicities, 
      each of whom had also received CCRT. CONCLUSION: The current study demonstrates 
      the efficacy and tolerability of HT for mCRC. To define optimal RT dose according 
      to tumor size of mCRC, further study should be needed.
FAU - Bae, Sun Hyun
AU  - Bae SH
AD  - Department of Radiation Oncology, Soonchunhyang University College of Medicine, 
      Bucheon, Korea.
FAU - Moon, Seong Kwon
AU  - Moon SK
AD  - Department of Radiation Oncology, Soonchunhyang University College of Medicine, 
      Bucheon, Korea.
FAU - Kim, Yong Ho
AU  - Kim YH
AD  - Department of Radiation Oncology, Catholic Kwandong University International St. 
      Mary's Hospital, Incheon, Korea.
FAU - Cho, Kwang Hwan
AU  - Cho KH
AD  - Department of Radiation Oncology, Soonchunhyang University College of Medicine, 
      Bucheon, Korea.
FAU - Shin, Eung Jin
AU  - Shin EJ
AD  - Department of General Surgery, Soonchunhyang University College of Medicine, 
      Bucheon, Korea.
FAU - Lee, Moon Sung
AU  - Lee MS
AD  - Division of Gastroenterology, Department of Internal Medicine, Soonchunhyang 
      University College of Medicine, Bucheon, Korea.
FAU - Ryu, Chang Beom
AU  - Ryu CB
AD  - Division of Gastroenterology, Department of Internal Medicine, Soonchunhyang 
      University College of Medicine, Bucheon, Korea.
FAU - Ko, Bong Min
AU  - Ko BM
AD  - Division of Gastroenterology, Department of Internal Medicine, Soonchunhyang 
      University College of Medicine, Bucheon, Korea.
FAU - Yun, Jina
AU  - Yun J
AD  - Division of Hematology-Oncology, Department of Internal Medicine, Soonchunhyang 
      University College of Medicine, Bucheon, Korea.
LA  - eng
PT  - Journal Article
DEP - 20151230
PL  - Korea (South)
TA  - Radiat Oncol J
JT  - Radiation oncology journal
JID - 101577577
PMC - PMC4707215
OTO - NOTNLM
OT  - Colorectal cancer
OT  - Helical tomotherapy
OT  - Metastases
COIS- Conflict of Interest: No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2016/01/13 06:00
MHDA- 2016/01/13 06:01
PMCR- 2015/12/01
CRDT- 2016/01/13 06:00
PHST- 2015/11/02 00:00 [received]
PHST- 2015/11/26 00:00 [revised]
PHST- 2015/12/10 00:00 [accepted]
PHST- 2016/01/13 06:00 [entrez]
PHST- 2016/01/13 06:00 [pubmed]
PHST- 2016/01/13 06:01 [medline]
PHST- 2015/12/01 00:00 [pmc-release]
AID - 10.3857/roj.2015.33.4.320 [doi]
PST - ppublish
SO  - Radiat Oncol J. 2015 Dec;33(4):320-7. doi: 10.3857/roj.2015.33.4.320. Epub 2015 
      Dec 30.