PMID- 26756321
OWN - NLM
STAT- MEDLINE
DCOM- 20161220
LR  - 20181202
IS  - 1616-5195 (Electronic)
IS  - 1616-5187 (Linking)
VI  - 16
IP  - 4
DP  - 2016 Apr
TI  - Three-Layered PCL Grafts Promoted Vascular Regeneration in a Rabbit Carotid 
      Artery Model.
PG  - 608-18
LID - 10.1002/mabi.201500355 [doi]
AB  - In this study, a three layered poly (epsilon-caprolactone) (PCL) graft (tPCL) was 
      fabricated by electrospinning PCL and electrospraying poly (ethylene oxide) 
      (PEO), which has a thin dense inner layer, a loose middle layer, and a dense 
      outer layer. Regular PCL grafts (rPCL) with only a dense layer were used as 
      control. In vivo evaluation was performed in rabbit carotid artery. Enhanced cell 
      infiltration, rapid regeneration of endothelium and smooth muscle layers, and 
      increased elastin deposition were observed within the tPCL graft wall. After 3 
      months, tPCL grafts showed faster PCL degradation than the rPCL grafts. 
      Infiltrated macrophages in the tPCL grafts secreted higher level of monocyte 
      chemoattractant protein-1 (MCP-1) and vascular endothelial growth factor (VEGF) 
      which enhanced vascular regeneration. In conclusion, the tPCL graft may be a 
      useful vascular prosthesis and worth for further investigation.
CI  - (c) 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Wang, Kai
AU  - Wang K
AD  - State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive 
      Materials, Ministry of Education, Nankai University, Tianjin, 300071, China.
FAU - Zheng, Wenting
AU  - Zheng W
AD  - State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive 
      Materials, Ministry of Education, Nankai University, Tianjin, 300071, China.
AD  - Department of Pathology, St. Jude Children Research Hospital, Memphis, TN, 38105, 
      USA.
FAU - Pan, Yiwa
AU  - Pan Y
AD  - State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive 
      Materials, Ministry of Education, Nankai University, Tianjin, 300071, China.
FAU - Ma, Shaoyang
AU  - Ma S
AD  - State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive 
      Materials, Ministry of Education, Nankai University, Tianjin, 300071, China.
FAU - Guan, Yong
AU  - Guan Y
AD  - Department of Urology Surgery, Children's Hospital, Tianjin, 300074, China.
FAU - Liu, Ruming
AU  - Liu R
AD  - State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive 
      Materials, Ministry of Education, Nankai University, Tianjin, 300071, China.
FAU - Zhu, Meifeng
AU  - Zhu M
AD  - State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive 
      Materials, Ministry of Education, Nankai University, Tianjin, 300071, China.
FAU - Zhou, Xin
AU  - Zhou X
AD  - State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive 
      Materials, Ministry of Education, Nankai University, Tianjin, 300071, China.
FAU - Zhang, Jun
AU  - Zhang J
AD  - State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive 
      Materials, Ministry of Education, Nankai University, Tianjin, 300071, China.
FAU - Zhao, Qiang
AU  - Zhao Q
AD  - State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive 
      Materials, Ministry of Education, Nankai University, Tianjin, 300071, China.
FAU - Zhu, Yan
AU  - Zhu Y
AD  - Center for Research and Development of Chinese Medicine, Tianjin State Key 
      Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese 
      Medicine, Tianjin, 300193, China.
FAU - Wang, Lianyong
AU  - Wang L
AD  - State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive 
      Materials, Ministry of Education, Nankai University, Tianjin, 300071, China.
FAU - Kong, Deling
AU  - Kong D
AD  - State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive 
      Materials, Ministry of Education, Nankai University, Tianjin, 300071, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160112
PL  - Germany
TA  - Macromol Biosci
JT  - Macromolecular bioscience
JID - 101135941
RN  - 0 (Chemokine CCL2)
RN  - 0 (MCP1 protein, rabbit)
RN  - 0 (Polyesters)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 24980-41-4 (polycaprolactone)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
SB  - IM
MH  - Animals
MH  - Blood Vessel Prosthesis/*veterinary
MH  - Carotid Artery Injuries/genetics/metabolism/pathology/*therapy
MH  - Carotid Artery, Common/drug effects
MH  - Cell Movement
MH  - Chemokine CCL2/genetics/metabolism
MH  - Electrochemical Techniques
MH  - Female
MH  - Gene Expression
MH  - Macrophages/cytology/drug effects/metabolism
MH  - Neovascularization, Physiologic/*drug effects
MH  - Polyesters/chemistry/*pharmacology
MH  - Polyethylene Glycols/chemistry/*pharmacology
MH  - Rabbits
MH  - Regeneration/drug effects
MH  - Tissue Engineering/*methods
MH  - Tissue Scaffolds
MH  - Vascular Endothelial Growth Factor A/genetics/metabolism
OTO - NOTNLM
OT  - cellular infiltration
OT  - electrospinning
OT  - poly(epsilon-caprolactone)
OT  - tissue engineering
OT  - vascular grafts
EDAT- 2016/01/13 06:00
MHDA- 2016/12/21 06:00
CRDT- 2016/01/13 06:00
PHST- 2015/09/22 00:00 [received]
PHST- 2015/11/28 00:00 [revised]
PHST- 2016/01/13 06:00 [entrez]
PHST- 2016/01/13 06:00 [pubmed]
PHST- 2016/12/21 06:00 [medline]
AID - 10.1002/mabi.201500355 [doi]
PST - ppublish
SO  - Macromol Biosci. 2016 Apr;16(4):608-18. doi: 10.1002/mabi.201500355. Epub 2016 
      Jan 12.