PMID- 26756979 OWN - NLM STAT- MEDLINE DCOM- 20160912 LR - 20220331 IS - 1365-2249 (Electronic) IS - 0009-9104 (Print) IS - 0009-9104 (Linking) VI - 184 IP - 2 DP - 2016 May TI - Immunometabolic biomarkers of inflammation in Behcet's disease: relationship with epidemiological profile, disease activity and therapeutic regimens. PG - 197-207 LID - 10.1111/cei.12768 [doi] AB - Behcet's disease (BD) is a systemic inflammatory disease with a still unclear pathogenesis. Although several inflammatory molecules have been studied, current biomarkers are largely insensitive in BD and unable to predict disease progression and response to treatment. Our primary aim was to explore serum levels of soluble CD40 L (sCD40L), soluble intracellular adhesion molecule (sICAM-1), monocyte chemoattractant protein-1 (MCP-1), myeloperoxidase (MPO), leptin, resistin, osteoprotegerin (OPG), soluble type 1 tumour necrosis factor receptor (sTNFR), interleukin (IL)-6 and serum amyloid A (SAA) serum concentration in a cohort of 27 BD patients. The secondary aim was to evaluate potential correlations between the putative circulating biomarkers, demographic profile of patients, the status of disease activity, the specific organ involvement at the time of sample collection and different therapeutic regimens. Serum concentrations of sTNFR (P = 0.008), leptin (P = 0.0011), sCD40L (P < 0.0001) and IL-6 (P = 0.0154) were significantly higher in BD patients than in HC, while no difference was found in MCP-1, MPO and resistin serum levels. Moreover, we observed significantly higher sTNFR serum concentrations in BD patients presenting inactive disease than HC (P = 0.0108). A correlation between sTNFR and age was also found, with higher levels in patients over 40 years than HC (P = 0.0329). Although further research is warranted to elucidate the role of circulating biomarkers, some of that may contribute to the understanding of the physiopathology processes underlying BD activity and damage as well as to provide useful tools for prognostic purposes and a personalized treatment approach. CI - (c) 2016 British Society for Immunology. FAU - Cantarini, L AU - Cantarini L AD - Research Center of Systemic Autoinflammatory Diseases and Behcet's Disease Clinic, Department of Medical Sciences, Surgery and Neurosciences, Universita Degli Studi Di Siena, Siena. FAU - Pucino, V AU - Pucino V AD - Dipartimento Di Scienze Mediche Traslazionali, Universita Di Napoli 'Federico II', Napoli, Italy. AD - William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK. FAU - Vitale, A AU - Vitale A AD - Research Center of Systemic Autoinflammatory Diseases and Behcet's Disease Clinic, Department of Medical Sciences, Surgery and Neurosciences, Universita Degli Studi Di Siena, Siena. FAU - Talarico, R AU - Talarico R AD - Unita Di Reumatologia, Dipartimento Di Medicina Clinica E Sperimentale, Universita Degli Studi Di Pisa, Pisa. FAU - Lucherini, O M AU - Lucherini OM AD - Research Center of Systemic Autoinflammatory Diseases and Behcet's Disease Clinic, Department of Medical Sciences, Surgery and Neurosciences, Universita Degli Studi Di Siena, Siena. FAU - Magnotti, F AU - Magnotti F AD - Research Center of Systemic Autoinflammatory Diseases and Behcet's Disease Clinic, Department of Medical Sciences, Surgery and Neurosciences, Universita Degli Studi Di Siena, Siena. FAU - De Rosa, V AU - De Rosa V AD - Laboratorio Di Immunologia, Istituto Di Endocrinologia E Oncologia Sperimentale, Consiglio Nazionale Delle Ricerche (IEOS-CNR), Napoli. AD - Unita Di NeuroImmunologia, IRCCS-Santa Lucia, Roma, Italy. FAU - Galgani, M AU - Galgani M AD - Laboratorio Di Immunologia, Istituto Di Endocrinologia E Oncologia Sperimentale, Consiglio Nazionale Delle Ricerche (IEOS-CNR), Napoli. FAU - Alviggi, C AU - Alviggi C AD - Dipartimento Di Neuroscienze E Scienze Riproduttive Ed Odontostomatologiche. FAU - Marone, G AU - Marone G AD - Dipartimento Di Scienze Mediche Traslazionali, Universita Di Napoli 'Federico II', Napoli, Italy. AD - Centro Interdipartimentale Di Ricerca in Scienze Immunologiche Di Base E Cliniche (CISI). FAU - Galeazzi, M AU - Galeazzi M AD - Research Center of Systemic Autoinflammatory Diseases and Behcet's Disease Clinic, Department of Medical Sciences, Surgery and Neurosciences, Universita Degli Studi Di Siena, Siena. FAU - Matarese, G AU - Matarese G AD - Laboratorio Di Immunologia, Istituto Di Endocrinologia E Oncologia Sperimentale, Consiglio Nazionale Delle Ricerche (IEOS-CNR), Napoli. AD - Dipartimento Di Medicina Molecolare E Biotecnologie Mediche, Universita Degli Studi Di Napoli 'Federico II', Napoli, Italy. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20160224 PL - England TA - Clin Exp Immunol JT - Clinical and experimental immunology JID - 0057202 RN - 0 (Biomarkers) RN - 0 (Cytokines) SB - IM MH - Behcet Syndrome/*blood/immunology/*pathology MH - Biomarkers/*blood MH - Body Mass Index MH - Cytokines/*blood MH - Female MH - Humans MH - Male MH - Middle Aged PMC - PMC4837234 OTO - NOTNLM OT - Behcet's disease OT - cytokines OT - leptin OT - metabolism OT - sTNFR EDAT- 2016/01/13 06:00 MHDA- 2016/09/13 06:00 PMCR- 2017/05/01 CRDT- 2016/01/13 06:00 PHST- 2015/12/02 00:00 [received] PHST- 2016/01/05 00:00 [revised] PHST- 2016/01/05 00:00 [accepted] PHST- 2016/01/13 06:00 [entrez] PHST- 2016/01/13 06:00 [pubmed] PHST- 2016/09/13 06:00 [medline] PHST- 2017/05/01 00:00 [pmc-release] AID - CEI12768 [pii] AID - 10.1111/cei.12768 [doi] PST - ppublish SO - Clin Exp Immunol. 2016 May;184(2):197-207. doi: 10.1111/cei.12768. Epub 2016 Feb 24.