PMID- 26758372
OWN - NLM
STAT- MEDLINE
DCOM- 20161005
LR  - 20181113
IS  - 1471-2261 (Electronic)
IS  - 1471-2261 (Linking)
VI  - 16
DP  - 2016 Jan 13
TI  - Hyperhomocysteinemia is associated with decreased apolipoprotein AI levels in 
      normal healthy people.
PG  - 10
LID - 10.1186/s12872-016-0186-6 [doi]
LID - 10
AB  - BACKGROUND: Hyperhomocysteinemia (HHcy) is an independent risk factor for various 
      cardiovascular diseases. Animal studies have shown that homocysteine (Hcy) 
      inhibits hepatic expression of apolipoprotein AI (apoAI). Our recent clinical 
      study showed that increased plasma Hcy levels were associated with decreased 
      apoAI levels in patients with impaired glucose tolerance. In this study, we 
      assessed a potential association between Hcy and apoAI levels in normal healthy 
      people. METHODS: A total of 1768 normal healthy individuals were divided into two 
      groups: the control group (subjects without HHcy) and the HHcy group (subjects 
      with HHcy). RESULTS: HHcy subjects exhibited significantly lower high-density 
      lipoprotein cholesterol (HDL-C) and apoAI levels than the control group (HDL-C: 
      1.18 +/- 0.25 vs. 1.29 +/- 0.32 mmol/L; apoAI: 1.38 +/- 0.19 vs. 1.47 +/- 0.25 g/L; all P 
      < 0.01). Plasma Hcy levels were negatively associated with HDL-C and apoAI levels 
      after adjustments for age, BMI and TG (HDL-C: r = -0.10; apoAI: r = -0.11; all P 
      < 0.05). Multivariate regression analysis showed that the plasma Hcy levels were 
      an independent influencing factor for apoAI (beta = -0.065, P < 0.05). CONCLUSIONS: 
      Increased plasma Hcy levels were associated with decreased apoAI levels in normal 
      healthy people, and the inhibition of apoAI synthesis might be a mechanism 
      through which Hcy is linked with the development of atherosclerosis in HHcy 
      subjects.
FAU - Wang, Ying
AU  - Wang Y
AD  - Physical Examination Center, Beijing Chao-yang Hospital, Capital Medical 
      University, NO. 8, Gongti South Road, Chaoyang district, Beijing, 100020, China.
FAU - Liu, Jia
AU  - Liu J
AD  - Department of Endocrinology, Beijing Chao-yang Hospital, Capital Medical 
      University, NO. 8, Gongti South Road, Chaoyang District, Beijing, 100020, China.
FAU - Jiang, Yuliang
AU  - Jiang Y
AD  - Department of Endocrinology, Beijing Chao-yang Hospital, Capital Medical 
      University, NO. 8, Gongti South Road, Chaoyang District, Beijing, 100020, China.
FAU - Zhang, Heng
AU  - Zhang H
AD  - Department of Endocrinology, Beijing Chao-yang Hospital, Capital Medical 
      University, NO. 8, Gongti South Road, Chaoyang District, Beijing, 100020, China.
FAU - Leng, Song
AU  - Leng S
AD  - Health Management Center, The Second Hospital of Dalian Medical University, NO. 
      467, Zhongshan Road, Shahekou District, Dalian, 116000, China. 
      dllengsong@126.com.
FAU - Wang, Guang
AU  - Wang G
AD  - Department of Endocrinology, Beijing Chao-yang Hospital, Capital Medical 
      University, NO. 8, Gongti South Road, Chaoyang District, Beijing, 100020, China. 
      drwg6688@yeah.net.
LA  - eng
PT  - Journal Article
DEP - 20160113
PL  - England
TA  - BMC Cardiovasc Disord
JT  - BMC cardiovascular disorders
JID - 100968539
RN  - 0 (Apolipoprotein A-I)
RN  - 0 (Apolipoproteins B)
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Adult
MH  - Apolipoprotein A-I/*blood
MH  - Apolipoproteins B/blood
MH  - Atherosclerosis/*blood
MH  - Blood Glucose/metabolism
MH  - Case-Control Studies
MH  - Cholesterol, HDL/blood
MH  - Cholesterol, LDL/blood
MH  - Female
MH  - Humans
MH  - Hyperhomocysteinemia/*blood
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Regression Analysis
MH  - Triglycerides/blood
PMC - PMC4711068
EDAT- 2016/01/14 06:00
MHDA- 2016/10/07 06:00
PMCR- 2016/01/13
CRDT- 2016/01/14 06:00
PHST- 2015/09/28 00:00 [received]
PHST- 2016/01/08 00:00 [accepted]
PHST- 2016/01/14 06:00 [entrez]
PHST- 2016/01/14 06:00 [pubmed]
PHST- 2016/10/07 06:00 [medline]
PHST- 2016/01/13 00:00 [pmc-release]
AID - 10.1186/s12872-016-0186-6 [pii]
AID - 186 [pii]
AID - 10.1186/s12872-016-0186-6 [doi]
PST - epublish
SO  - BMC Cardiovasc Disord. 2016 Jan 13;16:10. doi: 10.1186/s12872-016-0186-6.