PMID- 26758679 OWN - NLM STAT- MEDLINE DCOM- 20161213 LR - 20240324 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 6 DP - 2016 Jan 13 TI - Exposure to Polycyclic Aromatic Hydrocarbons, Plasma Cytokines, and Heart Rate Variability. PG - 19272 LID - 10.1038/srep19272 [doi] LID - 19272 AB - Epidemiological studies have suggested associations between polycyclic aromatic hydrocarbons (PAHs) and heart rate variability (HRV). However, the roles of plasma cytokines in these associations are limited. In discovery stage of this study, we used Human Cytokine Antibody Arrays to examine differences in the concentrations of 280 plasma cytokines between 8 coke-oven workers and 16 community residents. We identified 19 cytokines with significant different expression (fold change >/=2 or 16% BDNF decreases. Additionally, OH-PAHs were positively associated with activated leukocyte cell adhesion molecule (ALCAM) and C-reactive protein (CRP) (p < 0.05), and IQR increases in OH-PAHs were associated with >20% increases in CRP. We also found significant associations between these cytokines and HRV (p < 0.05), and IQR increases in BDNF and CRP were associated with >8% decreases in HRV. Our results indicated PAH exposure was associated with plasma cytokines, and higher cytokines were associated with decreased HRV, but additional human and potential mechanistic studies are needed. FAU - Yang, Binyao AU - Yang B AD - State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. AD - The Institute for Chemical Carcinogenesis, The State Key Lab of Respiratory Disease, Guangzhou Medical University, Guangzhou, Guangdong, China. FAU - Deng, Qifei AU - Deng Q AD - Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China. FAU - Zhang, Wangzhen AU - Zhang W AD - Institute of Industrial Health, Wuhan Iron and Steel Corporation, Wuhan, Hubei, China. FAU - Feng, Yingying AU - Feng Y AD - State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Dai, Xiayun AU - Dai X AD - State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Feng, Wei AU - Feng W AD - State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - He, Xiaosheng AU - He X AD - State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Huang, Suli AU - Huang S AD - State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Zhang, Xiao AU - Zhang X AD - State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Li, Xiaohai AU - Li X AD - State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Lin, Dafeng AU - Lin D AD - State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - He, Meian AU - He M AD - State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Guo, Huan AU - Guo H AD - State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Sun, Huizhen AU - Sun H AD - State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Yuan, Jing AU - Yuan J AD - State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Lu, Jiachun AU - Lu J AD - The Institute for Chemical Carcinogenesis, The State Key Lab of Respiratory Disease, Guangzhou Medical University, Guangzhou, Guangdong, China. FAU - Hu, Frank B AU - Hu FB AD - Department of Epidemiology, Harvard School of Public Health, Boston, USA. AD - Department of Nutrition, Harvard School of Public Health, Boston, USA. AD - Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA. FAU - Zhang, Xiaomin AU - Zhang X AD - State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Wu, Tangchun AU - Wu T AD - State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20160113 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (Biomarkers) RN - 0 (Cytokines) RN - 0 (Polycyclic Aromatic Hydrocarbons) SB - IM MH - Adult MH - Biomarkers MH - Case-Control Studies MH - Cluster Analysis MH - Cytokines/*blood MH - Environmental Exposure/*adverse effects MH - Enzyme-Linked Immunosorbent Assay MH - Female MH - Heart Rate/*drug effects MH - Humans MH - Male MH - Middle Aged MH - Polycyclic Aromatic Hydrocarbons/*pharmacology MH - Proteomics/methods MH - Risk Factors PMC - PMC4725366 EDAT- 2016/01/14 06:00 MHDA- 2016/12/15 06:00 PMCR- 2016/01/13 CRDT- 2016/01/14 06:00 PHST- 2015/09/29 00:00 [received] PHST- 2015/12/07 00:00 [accepted] PHST- 2016/01/14 06:00 [entrez] PHST- 2016/01/14 06:00 [pubmed] PHST- 2016/12/15 06:00 [medline] PHST- 2016/01/13 00:00 [pmc-release] AID - srep19272 [pii] AID - 10.1038/srep19272 [doi] PST - epublish SO - Sci Rep. 2016 Jan 13;6:19272. doi: 10.1038/srep19272.