PMID- 26758954
OWN - NLM
STAT- MEDLINE
DCOM- 20171030
LR  - 20191113
IS  - 1874-4702 (Electronic)
IS  - 1874-4672 (Linking)
VI  - 9
IP  - 4
DP  - 2016
TI  - Role of Hexokinase and VDAC in Neurological Disorders.
PG  - 320-331
AB  - Several neurological diseases such as bipolar disorders and schizophrenia are 
      linked to impaired brain energy metabolism. A key feature of brain bioenergetics 
      is hexokinase (HK) binding to the outer mitochondrial membrane through the 
      voltage dependent anion channel (VDAC). This has metabolic consequences, with 
      phosphorylation of glucose by mitochondrially bound hexokinase being closely 
      coupled to production of substrate ATP by intramitochondrial oxidative 
      phosphorylation. Additionally, binding of HK to mitochondria inhibits Bax-induced 
      cytochrome c release and apoptosis. Moreover VDAC1 expression level is elevated 
      in cerebellum of patients with Down  s syndrome, while in Alzheimer  s disease, 
      VDAC1 levels are decreased in frontal cortex and VDAC2 elevated in temporal 
      cortex. Thus, understanding the roles of VDAC and HK, either separate or 
      interacting in brain, provides new opportunities and challenges to elucidate 
      pathophysiological mechanisms for future therapeutic strategies.
FAU - Rosa, Jose Cesar
AU  - Rosa JC
FAU - Cesar, Marcelo de Cerqueira
AU  - Cesar MC
AD  - Laboratory of Neuroscience and Proteomics, School of Animal Science and Food 
      Engineering, University of Sao Paulo, Av. Duque de Caxias Norte 225, 13635-900, 
      Pirassununga, SP, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Mol Pharmacol
JT  - Current molecular pharmacology
JID - 101467997
RN  - 0 (Voltage-Dependent Anion Channels)
RN  - EC 2.7.1.1 (Hexokinase)
SB  - IM
MH  - Animals
MH  - Brain/metabolism/pathology
MH  - Hexokinase/*metabolism
MH  - Humans
MH  - Mitochondria/metabolism
MH  - Nervous System Diseases/*metabolism
MH  - Neurons/metabolism/pathology
MH  - Voltage-Dependent Anion Channels/*metabolism
EDAT- 2016/01/14 06:00
MHDA- 2017/10/31 06:00
CRDT- 2016/01/14 06:00
PHST- 2015/06/12 00:00 [received]
PHST- 2015/08/25 00:00 [revised]
PHST- 2015/01/06 00:00 [accepted]
PHST- 2016/01/14 06:00 [pubmed]
PHST- 2017/10/31 06:00 [medline]
PHST- 2016/01/14 06:00 [entrez]
AID - CMP-EPUB-73024 [pii]
AID - 10.2174/1874467209666160112123036 [doi]
PST - ppublish
SO  - Curr Mol Pharmacol. 2016;9(4):320-331. doi: 10.2174/1874467209666160112123036.