PMID- 26761187
OWN - NLM
STAT- MEDLINE
DCOM- 20161230
LR  - 20221207
IS  - 1607-842X (Electronic)
IS  - 0891-6934 (Linking)
VI  - 49
IP  - 3
DP  - 2016
TI  - Tumor necrosis factor (TNF)-alpha -308G/A (rs1800629) polymorphism distribution in 
      North India and its association with pemphigus: Case-control study and 
      meta-analysis.
PG  - 179-87
LID - 10.3109/08916934.2015.1134512 [doi]
AB  - Pemphigus is an autoimmune blistering disorder of skin and/or mucosal surfaces 
      characterized by intraepithelial lesions and immunoglobulin-G autoantibodies 
      against desmogleins (proteins critical in cell-to-cell adhesion). Genetic, 
      immunological, hormonal, and environmental factors are known to contribute to its 
      etiology. Tumor necrosis factor-alpha (TNF-alpha) which plays a key role in 
      pathogenesis of many infectious and inflammatory diseases has been found in high 
      levels in lesional skin and sera of pemphigus patients. However, studies on 
      association of single nucleotide polymorphism (SNP) in promoter region of TNF-alpha 
      at position -308 affecting G to A transition with pemphigus has been scarce. This 
      study was conducted to evaluate the TNF-alpha -308G/A SNP distribution in North 
      Indian cohort, and to define the association between the TNF-alpha -308G/A SNP 
      distribution and pemphigus, globally, by means of meta-analysis. TNF-alpha -308G/A 
      SNP in pemphigus patients was investigated by cytokine genotyping using genomic 
      DNA by PCR with sequence-specific primers. Meta-analysis of the data, including 
      four previously published studies from other populations, was performed to 
      generate a meaningful relationship. The results of our case-control study 
      indicate non-significant differences between patients and controls in TNF-alpha 
      -308G/A SNP. The meta-analysis also revealed that TNF-alpha -308G/A SNP is not 
      associated with pemphigus risk in population at large; however, it may be 
      contributing towards autoimmune phenomenon in pemphigus by being a part of its 
      multi-factorial etiology. This study provides evidence that the TNF-alpha -308G/A 
      polymorphism is not associated with overall pemphigus susceptibility. 
      Nevertheless, further studies on specific ethnicity and pemphigus variants are 
      necessary to validate the findings.
FAU - Dar, Sajad Ahmad
AU  - Dar SA
AD  - a Department of Microbiology , University College of Medical Sciences (University 
      of Delhi) & GTB Hospital , Delhi , India .
AD  - b Research and Scientific Studies Unit, College of Nursing and Allied Health 
      Sciences, University of Jazan , Jazan , Kingdom of Saudi Arabia .
FAU - Akhter, Naseem
AU  - Akhter N
AD  - c Department of Laboratory Medicine, Faculty of Applied Medical Sciences , Albaha 
      University , Albaha , Kingdom of Saudi Arabia .
FAU - Haque, Shafiul
AU  - Haque S
AD  - b Research and Scientific Studies Unit, College of Nursing and Allied Health 
      Sciences, University of Jazan , Jazan , Kingdom of Saudi Arabia .
AD  - d Centre for Drug Research, Faculty of Pharmacy, University of Helsinki , 
      Helsinki , Finland .
FAU - Singh, Taru
AU  - Singh T
AD  - a Department of Microbiology , University College of Medical Sciences (University 
      of Delhi) & GTB Hospital , Delhi , India .
FAU - Mandal, Raju Kumar
AU  - Mandal RK
AD  - b Research and Scientific Studies Unit, College of Nursing and Allied Health 
      Sciences, University of Jazan , Jazan , Kingdom of Saudi Arabia .
FAU - Ramachandran, Vishnampettai Ganapathysubramanian
AU  - Ramachandran VG
AD  - a Department of Microbiology , University College of Medical Sciences (University 
      of Delhi) & GTB Hospital , Delhi , India .
FAU - Bhattacharya, Sambit Nath
AU  - Bhattacharya SN
AD  - e Department of Dermatology , and.
FAU - Banerjee, Basu Dev
AU  - Banerjee BD
AD  - f Department of Biochemistry , University College of Medical Sciences (University 
      of Delhi) & GTB Hospital , Delhi , India.
FAU - Das, Shukla
AU  - Das S
AD  - a Department of Microbiology , University College of Medical Sciences (University 
      of Delhi) & GTB Hospital , Delhi , India .
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20160113
PL  - England
TA  - Autoimmunity
JT  - Autoimmunity
JID - 8900070
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - *Alleles
MH  - Case-Control Studies
MH  - Female
MH  - *Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - India
MH  - Male
MH  - Odds Ratio
MH  - Pemphigus/diagnosis/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Publication Bias
MH  - Tumor Necrosis Factor-alpha/*genetics
MH  - White People/*genetics
OTO - NOTNLM
OT  - Autoimmune skin disease
OT  - cytokines
OT  - pathogenesis
OT  - single-nucleotide polymorphism
OT  - susceptibility
EDAT- 2016/01/14 06:00
MHDA- 2016/12/31 06:00
CRDT- 2016/01/14 06:00
PHST- 2016/01/14 06:00 [entrez]
PHST- 2016/01/14 06:00 [pubmed]
PHST- 2016/12/31 06:00 [medline]
AID - 10.3109/08916934.2015.1134512 [doi]
PST - ppublish
SO  - Autoimmunity. 2016;49(3):179-87. doi: 10.3109/08916934.2015.1134512. Epub 2016 
      Jan 13.