PMID- 26761397
OWN - NLM
STAT- MEDLINE
DCOM- 20160706
LR  - 20160219
IS  - 1096-0341 (Electronic)
IS  - 0042-6822 (Linking)
VI  - 489
DP  - 2016 Feb
TI  - Human herpesvirus 6 U11 protein is critical for virus infection.
PG  - 151-7
LID - S0042-6822(15)00532-2 [pii]
LID - 10.1016/j.virol.2015.12.011 [doi]
AB  - All herpesviruses contain a tegument layer comprising a protein matrix; these 
      proteins play key roles during viral assembly and egress. Here, liquid 
      chromatography and tandem mass spectrometry analysis (LC-MS/MS) of proteins from 
      human herpesvirus 6 (HHV-6)-infected cells revealed a possible association 
      between two major tegument proteins, U14 and U11. This association was verified 
      by immunoprecipitation experiments. Moreover, U11 protein was expressed during 
      the late phase of infection and incorporated into virions. Finally, in contrast 
      to its revertant, a U11 deletion mutant could not be reconstituted. Taken 
      together, these results suggest that HHV-6 U11 is an essential gene for virus 
      growth and propagation.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Mahmoud, Nora F
AU  - Mahmoud NF
AD  - Division of Clinical Virology, Center for Infectious Diseases, Kobe University 
      Graduate School of Medicine, Kobe, Japan; Faculty of Pharmacy, Suez Canal 
      University, Ismailia, Egypt.
FAU - Kawabata, Akiko
AU  - Kawabata A
AD  - Division of Clinical Virology, Center for Infectious Diseases, Kobe University 
      Graduate School of Medicine, Kobe, Japan.
FAU - Tang, Huamin
AU  - Tang H
AD  - Division of Clinical Virology, Center for Infectious Diseases, Kobe University 
      Graduate School of Medicine, Kobe, Japan; Department of Immunology, Nanjing 
      Medical University, Nanjing, China.
FAU - Wakata, Aika
AU  - Wakata A
AD  - Division of Clinical Virology, Center for Infectious Diseases, Kobe University 
      Graduate School of Medicine, Kobe, Japan.
FAU - Wang, Bochao
AU  - Wang B
AD  - Division of Clinical Virology, Center for Infectious Diseases, Kobe University 
      Graduate School of Medicine, Kobe, Japan.
FAU - Serada, Satoshi
AU  - Serada S
AD  - Laboratory of Immune Signal, National Institutes of Biomedical Innovation, Health 
      and Nutrition, Japan.
FAU - Naka, Tetsuji
AU  - Naka T
AD  - Laboratory of Immune Signal, National Institutes of Biomedical Innovation, Health 
      and Nutrition, Japan.
FAU - Mori, Yasuko
AU  - Mori Y
AD  - Division of Clinical Virology, Center for Infectious Diseases, Kobe University 
      Graduate School of Medicine, Kobe, Japan. Electronic address: 
      ymori@med.kobe-u.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160104
PL  - United States
TA  - Virology
JT  - Virology
JID - 0110674
RN  - 0 (Viral Structural Proteins)
SB  - IM
MH  - Herpesvirus 6, Human/genetics/growth & development/*metabolism
MH  - Humans
MH  - Protein Binding
MH  - Roseolovirus Infections/*virology
MH  - Viral Structural Proteins/genetics/*metabolism
OTO - NOTNLM
OT  - HHV-6
OT  - Tegument protein
OT  - U11
OT  - U14
EDAT- 2016/01/14 06:00
MHDA- 2016/07/07 06:00
CRDT- 2016/01/14 06:00
PHST- 2015/10/19 00:00 [received]
PHST- 2015/12/01 00:00 [revised]
PHST- 2015/12/19 00:00 [accepted]
PHST- 2016/01/14 06:00 [entrez]
PHST- 2016/01/14 06:00 [pubmed]
PHST- 2016/07/07 06:00 [medline]
AID - S0042-6822(15)00532-2 [pii]
AID - 10.1016/j.virol.2015.12.011 [doi]
PST - ppublish
SO  - Virology. 2016 Feb;489:151-7. doi: 10.1016/j.virol.2015.12.011. Epub 2016 Jan 4.