PMID- 26761681
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160114
LR  - 20201001
IS  - 1225-8563 (Print)
IS  - 2234-246X (Electronic)
IS  - 1225-8563 (Linking)
VI  - 34
IP  - 6
DP  - 2014
TI  - Lysate of Probiotic Lactobacillus plantarum K8 Modulate the Mucosal Inflammatory 
      System in Dextran Sulfate Sodium-induced Colitic Rats.
PG  - 829-35
LID - 10.5851/kosfa.2014.34.6.829 [doi]
AB  - Inflammatory bowel disease (IBD) is caused by dysregulation of colon mucosal 
      immunity and mucosal epithelial barrier function. Recent studies have reported 
      that lipoteichoic acid (LTA) from Lactobacillus plantarum K8 reduces excessive 
      production of pro-inflammatory cytokine. In this study, we investigated the 
      preventive effects of lysate of Lb. plantarum K8 in dextran sulfate sodium 
      (DSS)-induced colitis. Male Sprague-Dawley rats were orally pretreated with 
      lysate of Lb. plantarum K8 (low dose or high dose) or live Lb. plantarum K8 prior 
      to the induction of colitis using 4% DSS. Disease progression was monitored by 
      assessment of disease activity index (DAI). Histological changes of colonic 
      tissues were evaluated by hematoxylin and eosin (HE) staining. Tumor necrosis 
      factor-alpha (TNF-alpha), interleukin-6 (IL-6) levels were measured using 
      enzyme-linked immunosorbent assay (ELISA). The colon mRNA expressions of TNF-alpha, 
      IL-6, and toll like receptor-2 (TLR-2) were examined by quantitative 
      real-time-transcription polymerase chain reaction (qPCR). Lysate of Lb. plantarum 
      K8 suppressed colon shortening, edema, mucosal damage, and the loss of 
      DSS-induced crypts. The groups that received lysate of Lb. plantarum K8 exhibited 
      significantly decreased levels of the pro-inflammatory cytokines TNF-alpha and IL-6 
      in the colon. Interestingly, colonic expression of toll like receptor-2 mRNA in 
      the high-dose lysate of Lb. plantarum K8 group increased significantly. Our study 
      demonstrates the protective effects of oral lysate of Lb. plantarum K8 
      administration on DSS-induced colitis via the modulation of pro-inflammatory 
      mediators of the mucosal immune system.
FAU - Ahn, Young-Sook
AU  - Ahn YS
AD  - Department of Nutritional Science and Food Management, Ewha Womans University, 
      Seoul 120-750, Korea.
FAU - Park, Min Young
AU  - Park MY
AD  - Department of Nutritional Science and Food Management, Ewha Womans University, 
      Seoul 120-750, Korea.
FAU - Shin, Jae-Ho
AU  - Shin JH
AD  - Department of Biomedical Laboratory Science, Eulji University, Seongnam 461-713, 
      Korea.
FAU - Kim, Ji Yeon
AU  - Kim JY
AD  - Department of Food Science and Technology, Seoul National University of Science 
      and Technology, Seoul 139-743, Korea.
FAU - Kwon, Oran
AU  - Kwon O
AD  - Department of Nutritional Science and Food Management, Ewha Womans University, 
      Seoul 120-750, Korea.
LA  - eng
PT  - Journal Article
DEP - 20141231
PL  - Korea (South)
TA  - Korean J Food Sci Anim Resour
JT  - Korean journal for food science of animal resources
JID - 101660566
PMC - PMC4662199
OTO - NOTNLM
OT  - colitis
OT  - lysate of Lactobacillus plantarum K8
OT  - pro-inflammatory cytokines
OT  - toll-like receptor 2
EDAT- 2014/01/01 00:00
MHDA- 2014/01/01 00:01
PMCR- 2014/01/01
CRDT- 2016/01/14 06:00
PHST- 2014/09/26 00:00 [received]
PHST- 2014/11/04 00:00 [revised]
PHST- 2014/11/06 00:00 [accepted]
PHST- 2016/01/14 06:00 [entrez]
PHST- 2014/01/01 00:00 [pubmed]
PHST- 2014/01/01 00:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - kosfa-34-829 [pii]
AID - 10.5851/kosfa.2014.34.6.829 [doi]
PST - ppublish
SO  - Korean J Food Sci Anim Resour. 2014;34(6):829-35. doi: 
      10.5851/kosfa.2014.34.6.829. Epub 2014 Dec 31.