PMID- 26763280
OWN - NLM
STAT- MEDLINE
DCOM- 20160502
LR  - 20220321
IS  - 1942-0080 (Electronic)
IS  - 1941-9651 (Print)
IS  - 1941-9651 (Linking)
VI  - 9
IP  - 1
DP  - 2016 Jan
TI  - Prognosis of Myocardial Damage in Sarcoidosis Patients With Preserved Left 
      Ventricular Ejection Fraction: Risk Stratification Using Cardiovascular Magnetic 
      Resonance.
PG  - e003738
LID - 10.1161/CIRCIMAGING.115.003738 [doi]
LID - e003738
AB  - BACKGROUND: Cardiac sarcoidosis is associated with an increased risk of heart 
      failure and sudden death, but its risk in patients with preserved left 
      ventricular ejection fraction is unknown. Using cardiovascular magnetic resonance 
      in patients with extracardiac sarcoidosis and preserved left ventricular ejection 
      fraction, we sought to (1) determine the prevalence of cardiac sarcoidosis or 
      associated myocardial damage, defined by the presence of late gadolinium 
      enhancement (LGE), (2) quantify their risk of death/ventricular tachycardia (VT), 
      and (3) identify imaging-based covariates that predict who is at greatest risk of 
      death/VT. METHODS AND RESULTS: Parameters of left and right ventricular function 
      and LGE burden were measured in 205 patients with left ventricular ejection 
      fraction >50% and extracardiac sarcoidosis who underwent cardiovascular magnetic 
      resonance for LGE evaluation. The association between covariates and death/VT in 
      the entire group and within the LGE+ group was determined using Cox proportional 
      hazard models and time-dependent receiver-operator curves analysis. Forty-one of 
      205 patients (20%) had LGE; 12 of 205 (6%) died or had VT during follow-up; of 
      these, 10 (83%) were in the LGE+ group. In the LGE+ group (1) the rate of 
      death/VT per year was >20x higher than LGE- (4.9 versus 0.2%, P<0.01); (2) 
      death/VT were associated with a greater burden of LGE (14+/-11 versus 5+/-5%, P<0.01) 
      and right ventricular dysfunction (right ventricular EF 45+/-12 versus 53+/-28%, 
      P=0.04). LGE burden was the best predictor of death/VT (area under the 
      receiver-operating characteristics curve, 0.80); for every 1% increase of LGE 
      burden, the hazard of death/VT increased by 8%. CONCLUSIONS: Sarcoidosis patients 
      with LGE are at significant risk for death/VT, even with preserved left 
      ventricular ejection fraction. Increased LGE burden and right ventricular 
      dysfunction can identify LGE+ patients at highest risk of death/VT.
CI  - (c) 2016 The Authors.
FAU - Murtagh, Gillian
AU  - Murtagh G
AD  - From the Departments of Medicine (G.M., L.J.L., F.M., C.A.B., A.V.P., Z.Y., K.A., 
      V.M.-A., J.D.M., D.K.H., R.M.L., A.R.P.) and Radiology (R.M.L., A.R.P.), 
      University of Chicago, IL; Department of Medicine, Mayo Clinic, Phoenix, AZ 
      (J.F.B.); and Department of Medicine, University of Illinois at Chicago (N.J.S.).
FAU - Laffin, Luke J
AU  - Laffin LJ
AD  - From the Departments of Medicine (G.M., L.J.L., F.M., C.A.B., A.V.P., Z.Y., K.A., 
      V.M.-A., J.D.M., D.K.H., R.M.L., A.R.P.) and Radiology (R.M.L., A.R.P.), 
      University of Chicago, IL; Department of Medicine, Mayo Clinic, Phoenix, AZ 
      (J.F.B.); and Department of Medicine, University of Illinois at Chicago (N.J.S.).
FAU - Beshai, John F
AU  - Beshai JF
AD  - From the Departments of Medicine (G.M., L.J.L., F.M., C.A.B., A.V.P., Z.Y., K.A., 
      V.M.-A., J.D.M., D.K.H., R.M.L., A.R.P.) and Radiology (R.M.L., A.R.P.), 
      University of Chicago, IL; Department of Medicine, Mayo Clinic, Phoenix, AZ 
      (J.F.B.); and Department of Medicine, University of Illinois at Chicago (N.J.S.).
FAU - Maffessanti, Francesco
AU  - Maffessanti F
AD  - From the Departments of Medicine (G.M., L.J.L., F.M., C.A.B., A.V.P., Z.Y., K.A., 
      V.M.-A., J.D.M., D.K.H., R.M.L., A.R.P.) and Radiology (R.M.L., A.R.P.), 
      University of Chicago, IL; Department of Medicine, Mayo Clinic, Phoenix, AZ 
      (J.F.B.); and Department of Medicine, University of Illinois at Chicago (N.J.S.).
FAU - Bonham, Catherine A
AU  - Bonham CA
AD  - From the Departments of Medicine (G.M., L.J.L., F.M., C.A.B., A.V.P., Z.Y., K.A., 
      V.M.-A., J.D.M., D.K.H., R.M.L., A.R.P.) and Radiology (R.M.L., A.R.P.), 
      University of Chicago, IL; Department of Medicine, Mayo Clinic, Phoenix, AZ 
      (J.F.B.); and Department of Medicine, University of Illinois at Chicago (N.J.S.).
FAU - Patel, Amit V
AU  - Patel AV
AD  - From the Departments of Medicine (G.M., L.J.L., F.M., C.A.B., A.V.P., Z.Y., K.A., 
      V.M.-A., J.D.M., D.K.H., R.M.L., A.R.P.) and Radiology (R.M.L., A.R.P.), 
      University of Chicago, IL; Department of Medicine, Mayo Clinic, Phoenix, AZ 
      (J.F.B.); and Department of Medicine, University of Illinois at Chicago (N.J.S.).
FAU - Yu, Zoe
AU  - Yu Z
AD  - From the Departments of Medicine (G.M., L.J.L., F.M., C.A.B., A.V.P., Z.Y., K.A., 
      V.M.-A., J.D.M., D.K.H., R.M.L., A.R.P.) and Radiology (R.M.L., A.R.P.), 
      University of Chicago, IL; Department of Medicine, Mayo Clinic, Phoenix, AZ 
      (J.F.B.); and Department of Medicine, University of Illinois at Chicago (N.J.S.).
FAU - Addetia, Karima
AU  - Addetia K
AD  - From the Departments of Medicine (G.M., L.J.L., F.M., C.A.B., A.V.P., Z.Y., K.A., 
      V.M.-A., J.D.M., D.K.H., R.M.L., A.R.P.) and Radiology (R.M.L., A.R.P.), 
      University of Chicago, IL; Department of Medicine, Mayo Clinic, Phoenix, AZ 
      (J.F.B.); and Department of Medicine, University of Illinois at Chicago (N.J.S.).
FAU - Mor-Avi, Victor
AU  - Mor-Avi V
AD  - From the Departments of Medicine (G.M., L.J.L., F.M., C.A.B., A.V.P., Z.Y., K.A., 
      V.M.-A., J.D.M., D.K.H., R.M.L., A.R.P.) and Radiology (R.M.L., A.R.P.), 
      University of Chicago, IL; Department of Medicine, Mayo Clinic, Phoenix, AZ 
      (J.F.B.); and Department of Medicine, University of Illinois at Chicago (N.J.S.).
FAU - Moss, Joshua D
AU  - Moss JD
AD  - From the Departments of Medicine (G.M., L.J.L., F.M., C.A.B., A.V.P., Z.Y., K.A., 
      V.M.-A., J.D.M., D.K.H., R.M.L., A.R.P.) and Radiology (R.M.L., A.R.P.), 
      University of Chicago, IL; Department of Medicine, Mayo Clinic, Phoenix, AZ 
      (J.F.B.); and Department of Medicine, University of Illinois at Chicago (N.J.S.).
FAU - Hogarth, D Kyle
AU  - Hogarth DK
AD  - From the Departments of Medicine (G.M., L.J.L., F.M., C.A.B., A.V.P., Z.Y., K.A., 
      V.M.-A., J.D.M., D.K.H., R.M.L., A.R.P.) and Radiology (R.M.L., A.R.P.), 
      University of Chicago, IL; Department of Medicine, Mayo Clinic, Phoenix, AZ 
      (J.F.B.); and Department of Medicine, University of Illinois at Chicago (N.J.S.).
FAU - Sweiss, Nadera J
AU  - Sweiss NJ
AD  - From the Departments of Medicine (G.M., L.J.L., F.M., C.A.B., A.V.P., Z.Y., K.A., 
      V.M.-A., J.D.M., D.K.H., R.M.L., A.R.P.) and Radiology (R.M.L., A.R.P.), 
      University of Chicago, IL; Department of Medicine, Mayo Clinic, Phoenix, AZ 
      (J.F.B.); and Department of Medicine, University of Illinois at Chicago (N.J.S.).
FAU - Lang, Roberto M
AU  - Lang RM
AD  - From the Departments of Medicine (G.M., L.J.L., F.M., C.A.B., A.V.P., Z.Y., K.A., 
      V.M.-A., J.D.M., D.K.H., R.M.L., A.R.P.) and Radiology (R.M.L., A.R.P.), 
      University of Chicago, IL; Department of Medicine, Mayo Clinic, Phoenix, AZ 
      (J.F.B.); and Department of Medicine, University of Illinois at Chicago (N.J.S.).
FAU - Patel, Amit R
AU  - Patel AR
AD  - From the Departments of Medicine (G.M., L.J.L., F.M., C.A.B., A.V.P., Z.Y., K.A., 
      V.M.-A., J.D.M., D.K.H., R.M.L., A.R.P.) and Radiology (R.M.L., A.R.P.), 
      University of Chicago, IL; Department of Medicine, Mayo Clinic, Phoenix, AZ 
      (J.F.B.); and Department of Medicine, University of Illinois at Chicago (N.J.S.). 
      amitpatel@uchicago.edu.
LA  - eng
GR  - T32 HL007605/HL/NHLBI NIH HHS/United States
GR  - UL1 TR000430/TR/NCATS NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Circ Cardiovasc Imaging
JT  - Circulation. Cardiovascular imaging
JID - 101479935
RN  - 0 (Contrast Media)
SB  - IM
CIN - Circ Cardiovasc Imaging. 2016 Jan;9(1):e004417. PMID: 26763282
MH  - Biopsy
MH  - Cardiomyopathies/*physiopathology
MH  - Contrast Media
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Sarcoidosis/*physiopathology
MH  - Stroke Volume/physiology
MH  - Ventricular Function, Left/*physiology
PMC - PMC4718184
OTO - NOTNLM
OT  - cardiac arrhythmias
OT  - cardiac magnetic resonance
OT  - cardiomyopathy
OT  - defibrillator
OT  - gadolinium
OT  - heart failure
OT  - sarcoidosis
EDAT- 2016/01/15 06:00
MHDA- 2016/05/03 06:00
PMCR- 2016/01/19
CRDT- 2016/01/15 06:00
PHST- 2016/01/15 06:00 [entrez]
PHST- 2016/01/15 06:00 [pubmed]
PHST- 2016/05/03 06:00 [medline]
PHST- 2016/01/19 00:00 [pmc-release]
AID - CIRCIMAGING.115.003738 [pii]
AID - 10.1161/CIRCIMAGING.115.003738 [doi]
PST - ppublish
SO  - Circ Cardiovasc Imaging. 2016 Jan;9(1):e003738. doi: 
      10.1161/CIRCIMAGING.115.003738.