PMID- 26763852
OWN - NLM
STAT- MEDLINE
DCOM- 20170807
LR  - 20181113
IS  - 1348-4214 (Electronic)
IS  - 0916-9636 (Linking)
VI  - 39
IP  - 5
DP  - 2016 May
TI  - Biomarkers of lipid peroxidation related to hypertension in aging.
PG  - 342-8
LID - 10.1038/hr.2015.156 [doi]
AB  - The aim of this clinical study was to evaluate the influence of aging on the 
      levels of lipid peroxidation (quantified as thiobarbituric acid-reactive 
      substances (TBARS) content), lipid hydroperoxide (LOOH), hexanoyl lysine (HEL), 
      8-iso-prostaglandin F2alpha (8-iso-PGF2alpha) and total antioxidant capacity (TAC), and 
      determine their relationships to the demographic and cardiovascular risk factors 
      in elderly hypertensive (HT) patients. This study consisted of four groups: two 
      elderly groups with 30 HT patients (11 males, 19 females) and 30 normotensive 
      healthy volunteers (15 males, 15 females), and two young groups with 30 HT 
      patients (13 males, 17 females) and 30 normotensive healthy volunteers (12 males, 
      18 females). In the elderly control group, the TBARS, LOOH, HEL and 8-iso-PGF2alpha 
      levels, and the carotid intima media thickness (CIMT) were significantly higher 
      than in the young control group. The TBARS, LOOH, HEL and 8-iso-PGF2alpha levels and 
      the CIMT measurements were significantly higher in the elderly HT group than in 
      the young HT group. In addition, the TAC levels were significantly lower in the 
      elderly and young HT groups than in the elderly and young control groups. The 
      CIMT was significantly positively correlated with TBARS (r=0.40, P<0.001), HEL 
      (r= 0.30, P=0.001), LOOH (r= 0.44, P<0.001) and 8-iso-PGF2alpha (r= 0.32, P<0.001) in 
      all of the HT groups. It seems that in elderly patients, the LOOH and TBARS are 
      better biomarkers of lipid peroxidation in hypertension in terms of sensitivity. 
      In all of the HT groups, 8-iso-PGF2alpha had the highest sensitivity. Hypertension is 
      associated with lipid peroxidation due to an impaired oxidant/antioxidant status. 
      Increased lipid peroxidation and decreased antioxidants with aging indicate that 
      peroxidative damage further increases with higher blood pressure and the aging 
      process.
FAU - Yavuzer, Hakan
AU  - Yavuzer H
AD  - Department of Internal Medicine, Division of Geriatrics, Cerrahpasa Faculty of 
      Medicine, Istanbul University, Istanbul, Turkey.
FAU - Yavuzer, Serap
AU  - Yavuzer S
AD  - Department of Internal Medicine, Cerrahpasa Faculty of Medicine, Istanbul 
      University, Istanbul, Turkey.
FAU - Cengiz, Mahir
AU  - Cengiz M
AD  - Department of Internal Medicine, Cerrahpasa Faculty of Medicine, Istanbul 
      University, Istanbul, Turkey.
FAU - Erman, Hayriye
AU  - Erman H
AD  - Medical Biohemistry Department, Medeniyet University, Goztepe Training and 
      Research Hospital, Istanbul, Turkey.
FAU - Doventas, Alper
AU  - Doventas A
AD  - Department of Internal Medicine, Division of Geriatrics, Cerrahpasa Faculty of 
      Medicine, Istanbul University, Istanbul, Turkey.
FAU - Balci, Huriye
AU  - Balci H
AD  - Central Research Laboratory, Cerrahpasa Faculty of Medicine, Istanbul University, 
      Istanbul, Turkey.
FAU - Erdincler, Deniz Suna
AU  - Erdincler DS
AD  - Department of Internal Medicine, Division of Geriatrics, Cerrahpasa Faculty of 
      Medicine, Istanbul University, Istanbul, Turkey.
FAU - Uzun, Hafize
AU  - Uzun H
AD  - Department of Biochemistry, Cerrahpasa Faculty of Medicine, Istanbul University, 
      Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20160114
PL  - England
TA  - Hypertens Res
JT  - Hypertension research : official journal of the Japanese Society of Hypertension
JID - 9307690
RN  - 0 (Biomarkers)
RN  - 0 (Lipid Peroxides)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 27415-26-5 (8-epi-prostaglandin F2alpha)
RN  - B7IN85G1HY (Dinoprost)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*blood
MH  - Biomarkers/blood
MH  - Carotid Intima-Media Thickness
MH  - Dinoprost/analogs & derivatives/blood
MH  - Female
MH  - Healthy Volunteers
MH  - Humans
MH  - Hypertension/blood/*diagnosis
MH  - Lipid Peroxidation/*physiology
MH  - Lipid Peroxides/blood
MH  - Male
MH  - Middle Aged
MH  - Risk Assessment
MH  - Risk Factors
MH  - Sensitivity and Specificity
MH  - Thiobarbituric Acid Reactive Substances/*metabolism
EDAT- 2016/01/15 06:00
MHDA- 2017/08/08 06:00
CRDT- 2016/01/15 06:00
PHST- 2015/07/06 00:00 [received]
PHST- 2015/10/31 00:00 [revised]
PHST- 2015/11/04 00:00 [accepted]
PHST- 2016/01/15 06:00 [entrez]
PHST- 2016/01/15 06:00 [pubmed]
PHST- 2017/08/08 06:00 [medline]
AID - hr2015156 [pii]
AID - 10.1038/hr.2015.156 [doi]
PST - ppublish
SO  - Hypertens Res. 2016 May;39(5):342-8. doi: 10.1038/hr.2015.156. Epub 2016 Jan 14.