PMID- 26765095
OWN - NLM
STAT- MEDLINE
DCOM- 20161020
LR  - 20161230
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 454
DP  - 2016 Feb 15
TI  - Genetic variants within telomere-associated genes, leukocyte telomere length and 
      the risk of acute coronary syndrome in Czech women.
PG  - 62-5
LID - S0009-8981(15)30111-X [pii]
LID - 10.1016/j.cca.2015.12.041 [doi]
AB  - The association between leukocyte telomere length (LTL) and cardiovascular 
      disease (CVD) has been published in many reports, although almost exclusively in 
      men. In our study we analysed the association between LTL and five selected 
      variants within three candidate genes (TERC rs12696304; TERF2IP rs3784929 and 
      rs8053257; UCP2 rs659366 and rs622064), which are not only involved in 
      telomere-length maintenance but also potentially associated with higher risk of 
      acute coronary syndrome (ACS) in Czech women (505 cases and 642 controls). We 
      detected significantly shorter LTL in women with ACS (P<0.001), but the 
      difference disappeared after multiple adjustments. We did not find any 
      significant associations between analysed variants and LTL, except for rs622064 
      within the UCP2 gene, in which case AA homozygotes had a higher LTL (P<0.04). 
      Genotype frequencies of the analysed SNPs did not differ between controls and 
      women with ACS. Variants within UCP2 (rs622064; CC vs. A allele carriers OR=1.61; 
      95% CI: 1.21-2.15, P<0.002) and within TERF2IP (rs8053257; A allele carriers vs. 
      GG, OR=1.78; 95% CI: 1.07-3.18, P<0.03) were associated with increased risk of 
      type 2 diabetes mellitus (T2DM). Analysed polymorphisms were not major 
      determinants of telomere length or ACS risk in Czech females.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Dlouha, Dana
AU  - Dlouha D
AD  - Laboratory for Atherosclerosis Research, Centre for Experimental Medicine, 
      Institute for Clinical and Experimental Medicine, Prague, Czech Republic. 
      Electronic address: dadl@ikem.cz.
FAU - Pitha, Jan
AU  - Pitha J
AD  - Laboratory for Atherosclerosis Research, Centre for Experimental Medicine, 
      Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
FAU - Mesanyova, Jana
AU  - Mesanyova J
AD  - Laboratory for Atherosclerosis Research, Centre for Experimental Medicine, 
      Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
FAU - Mrazkova, Jolana
AU  - Mrazkova J
AD  - Laboratory for Atherosclerosis Research, Centre for Experimental Medicine, 
      Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
FAU - Fellnerova, Adela
AU  - Fellnerova A
AD  - Laboratory for Atherosclerosis Research, Centre for Experimental Medicine, 
      Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
FAU - Stanek, Vladimir
AU  - Stanek V
AD  - Department of Cardiology, Institute for Clinical and Experimental Medicine, 
      Prague, Czech Republic.
FAU - Lanska, Vera
AU  - Lanska V
AD  - Statistical Unit, Institute for Clinical and Experimental Medicine, Prague, Czech 
      Republic.
FAU - Hubacek, Jaroslav A
AU  - Hubacek JA
AD  - Laboratory for Atherosclerosis Research, Centre for Experimental Medicine, 
      Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160104
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
SB  - IM
MH  - Acute Coronary Syndrome/*genetics
MH  - Czech Republic
MH  - Female
MH  - Genetic Variation/*genetics
MH  - Humans
MH  - Leukocytes/*metabolism
MH  - Middle Aged
MH  - Risk Factors
MH  - Telomere/*genetics
MH  - Telomere Homeostasis/*genetics
OTO - NOTNLM
OT  - Acute coronary syndrome
OT  - Leukocyte telomere length
OT  - Polymorphism
OT  - Risk factors
OT  - Women
EDAT- 2016/01/15 06:00
MHDA- 2016/10/21 06:00
CRDT- 2016/01/15 06:00
PHST- 2015/07/22 00:00 [received]
PHST- 2015/12/28 00:00 [revised]
PHST- 2015/12/31 00:00 [accepted]
PHST- 2016/01/15 06:00 [entrez]
PHST- 2016/01/15 06:00 [pubmed]
PHST- 2016/10/21 06:00 [medline]
AID - S0009-8981(15)30111-X [pii]
AID - 10.1016/j.cca.2015.12.041 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2016 Feb 15;454:62-5. doi: 10.1016/j.cca.2015.12.041. Epub 2016 
      Jan 4.