PMID- 26765106 OWN - NLM STAT- MEDLINE DCOM- 20160726 LR - 20191210 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 11 IP - 1 DP - 2016 TI - Predictive Values of N-Terminal Pro-B-Type Natriuretic Peptide and Cardiac Troponin I for Myocardial Fibrosis in Hypertrophic Obstructive Cardiomyopathy. PG - e0146572 LID - 10.1371/journal.pone.0146572 [doi] LID - e0146572 AB - BACKGROUND: Both high-sensitivity cardiac troponin T and B-type natriuretic peptide are useful in detecting myocardial fibrosis, as determined by late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR), in patients with non-obstructive hypertrophic cardiomyopathy. However, their values to predict myocardial fibrosis in hypertrophic obstructive cardiomyopathy (HOCM) remain unclear. We investigated the role of N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP) and cardiac troponin I (cTnI) to identify LGE-CMR in patients with HOCM. METHODS: Peripheral concentrations of NT-proBNP and cTnI were determined in patients with HOCM (n = 163; age = 47.2 +/- 10.8 years; 38.7% females). Contrast-enhanced CMR was performed to identify and quantify myocardial fibrosis. RESULTS: LGE was detected in 120 of 163 patients (73.6%). Patients with LGE had significantly higher levels of NT-proBNP and cTnI than those without LGE (1386.2 [904.6-2340.8] vs. 866.6 [707.2-1875.2] pmol/L, P = 0.003; 0.024 [0.010-0.049] vs. 0.010 [0.005-0.021] ng/ml, P <0.001, respectively). The extent of LGE was positively correlated with log cTnI (r = 0.371, P <0.001) and log NT-proBNP (r = 0.211, P = 0.007). On multivariable analysis, both log cTnI and maximum wall thickness (MWT) were independent predictors of the presence of LGE (OR = 3.193, P = 0.033; OR = 1.410, P < 0.001, respectively), whereas log NT-proBNP was not. According to the ROC curve analysis, combined measurements of MWT >/=21 mm and/or cTnI >/=0.025 ng/ml indicated good diagnostic performance for the presence of LGE, with specificity of 95% or sensitivity of 88%. CONCLUSIONS: Serum cTnI is an independent predictor useful for identifying myocardial fibrosis, while plasma NT-proBNP is only associated with myocardial fibrosis on univariate analysis. Combined measurements of serum cTnI with MWT further improve its value in detecting myocardial fibrosis in patients with HOCM. FAU - Zhang, Changlin AU - Zhang C AD - State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. FAU - Liu, Rong AU - Liu R AD - State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. FAU - Yuan, Jiansong AU - Yuan J AD - State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. FAU - Cui, Jingang AU - Cui J AD - State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. FAU - Hu, Fenghuan AU - Hu F AD - State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. FAU - Yang, Weixian AU - Yang W AD - State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. FAU - Zhang, Yan AU - Zhang Y AD - State Key Laboratory of Cardiovascular Disease, Department of Radiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. FAU - Chen, Youzhou AU - Chen Y AD - State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. FAU - Qiao, Shubin AU - Qiao S AD - State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. LA - eng PT - Evaluation Study PT - Journal Article DEP - 20160114 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 0 (Biomarkers) RN - 0 (Troponin I) RN - 114471-18-0 (Natriuretic Peptide, Brain) SB - IM MH - Adult MH - Biomarkers/blood MH - Cardiomyopathy, Hypertrophic/*blood/pathology MH - Female MH - Fibrosis MH - Humans MH - Male MH - Middle Aged MH - Natriuretic Peptide, Brain/*blood MH - Predictive Value of Tests MH - Troponin I/*blood PMC - PMC4713160 COIS- Competing Interests: The authors have declared that no competing interests exist. EDAT- 2016/01/15 06:00 MHDA- 2016/07/28 06:00 PMCR- 2016/01/14 CRDT- 2016/01/15 06:00 PHST- 2015/08/11 00:00 [received] PHST- 2015/12/18 00:00 [accepted] PHST- 2016/01/15 06:00 [entrez] PHST- 2016/01/15 06:00 [pubmed] PHST- 2016/07/28 06:00 [medline] PHST- 2016/01/14 00:00 [pmc-release] AID - PONE-D-15-33682 [pii] AID - 10.1371/journal.pone.0146572 [doi] PST - epublish SO - PLoS One. 2016 Jan 14;11(1):e0146572. doi: 10.1371/journal.pone.0146572. eCollection 2016.