PMID- 26765476
OWN - NLM
STAT- MEDLINE
DCOM- 20160531
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 95
IP  - 2
DP  - 2016 Jan
TI  - Patients With Neurogenic Lower Urinary Tract Dysfunction Following Spinal Cord 
      Injury Are at Increased Risk of Developing Type 2 Diabetes Mellitus: A 
      Population-Based Cohort Study.
PG  - e2518
LID - 10.1097/MD.0000000000002518 [doi]
LID - e2518
AB  - To investigate whether patients with neurogenic lower urinary tract dysfunction 
      (NLUTD) following spinal cord injury (SCI) are at increased risk of developing 
      type 2 diabetes mellitus (T2DM).The retrospective cohort study used a subset of 
      the Taiwan National Health Insurance Research Database (NHIRD) comprising 
      information on 2 million beneficiaries randomly sampled from the general 
      population. A total of 3515 patients with newly diagnosed SCI were identified 
      during the period of 2001 to 2008. Among them, 170 developed NLUTD following SCI. 
      The control group was consisted of 656 patients without NLUTD over the study 
      period randomly selected by matching NLUTD cases on the date of NLUTD incidence, 
      age, sex, and duration since diagnosis of SCI. The study groups were then 
      followed to the end of 2009. T2DM was the end-point.The incidence rate ratios of 
      T2DM were higher in the NLUTD group than in the control group (4.94 vs. 2.61 per 
      10,000 person-years), representing an adjusted hazard ratio (AHR) of 1.70 (95% 
      confidence interval [CI] 1.11-2.61). Age-specific AHR was significantly elevated 
      only in patients aged > = 60 years (AHR = 2.52 (95% CI 1.35-4.70)).This study 
      showed that the NLUTD following SCI may significantly increase the risk of 
      developing T2DM.
FAU - Lien, Wei-Chih
AU  - Lien WC
AD  - From the Department of Physical Medicine and Rehabilitation, National Cheng Kung 
      University Hospital (W-CL, T-SK, Y-CL, P-CH); Department of Physical Medicine and 
      Rehabilitation, College of Medicine (T-SK, Y-CL); NCKU Research Center for Health 
      Data (F-WL); Department and Graduate Institute of Public Health, College of 
      Medicine, National Cheng Kung University, Tainan (F-WL, C-YL); and Department of 
      Public Health, College of Public Health, China Medical University, Taichung, 
      Taiwan (C-YL).
FAU - Kuan, Ta-Shen
AU  - Kuan TS
FAU - Lin, Yu-Ching
AU  - Lin YC
FAU - Liang, Fu-Wen
AU  - Liang FW
FAU - Hsieh, Pei-Chun
AU  - Hsieh PC
FAU - Li, Chung-Yi
AU  - Li CY
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/epidemiology/*etiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Spinal Cord Injuries/*complications/epidemiology
MH  - Taiwan/epidemiology
MH  - Urinary Bladder, Neurogenic/*complications/epidemiology
MH  - Young Adult
PMC - PMC4718302
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2016/01/15 06:00
MHDA- 2016/06/01 06:00
PMCR- 2016/01/15
CRDT- 2016/01/15 06:00
PHST- 2016/01/15 06:00 [entrez]
PHST- 2016/01/15 06:00 [pubmed]
PHST- 2016/06/01 06:00 [medline]
PHST- 2016/01/15 00:00 [pmc-release]
AID - 00005792-201601120-00084 [pii]
AID - 10.1097/MD.0000000000002518 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2016 Jan;95(2):e2518. doi: 10.1097/MD.0000000000002518.