PMID- 26766967
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160115
LR  - 20181113
IS  - 1759-7706 (Print)
IS  - 1759-7714 (Electronic)
IS  - 1759-7706 (Linking)
VI  - 5
IP  - 1
DP  - 2014 Jan
TI  - Increased hepcidin expression in non-small cell lung cancer tissue and serum is 
      associated with clinical stage.
PG  - 14-24
LID - 10.1111/1759-7714.12046 [doi]
AB  - BACKGROUND: Hepcidin is a small secreted peptide that plays a key role in iron 
      metabolism. A high level of hepcidin expression may be implicated in colorectal 
      cancer; however, the relationship between hepcidin and lung cancer has not yet 
      been studied. METHODS: Serum hepcidin-25, bone morphogenetic protein (BMP)-2, and 
      interleukin (IL)-6 concentration in 53 patients and 16 non-cancerous individuals 
      was measured by enzyme-linked immune sorbent assay. Reverse transcriptase 
      quantitative polymerase chain reaction (RT-qPCR) was utilized to study the 
      expression of hepcidin mRNA in paired tumor and non-tumor lung tissues in 
      surgical specimens from 65 patients with non small cell lung cancer (NSCLC), as 
      well as in six types of lung cancer cell lines and human bronchial epithelial 
      (HBE) cells. Hepcidin protein expression and cellular localization in NSCLC was 
      determined by immunohistochemistry. RESULTS: The serum hepcidin-25 concentration 
      was higher in patients with NSCLC than in non-cancerous individuals, and was 
      positively correlated with serum BMP2 concentration, but negatively with serum 
      IL-6 levels. Serum hepcidin was also correlated with lymph node metastasis and 
      clinical stage. Hepcidin mRNA expression was higher in cancerous tissues of NSCLC 
      than in normal pulmonary tissues (P = 0.001). Hepcidin mRNA levels in four lung 
      carcinoma cell lines were higher than in HBE cells. Immunohistochemistry showed 
      that hepcidin protein was increased in cancerous tissues of NSCLC. CONCLUSIONS: 
      The level of hepcidin expression increased in NSCLC tissue and serum. Serum 
      hepcidin-25 level was associated with lymph node metastasis and tumor clinical 
      stage in patients with NSCLC.
FAU - Chen, Qian
AU  - Chen Q
AD  - Department of Cardio-Thoracic Surgery, Second Xiangya Hospital of Central South 
      University Changsha, China.
FAU - Wang, Li
AU  - Wang L
AD  - Department of Cardio-Thoracic Surgery, Second Xiangya Hospital of Central South 
      University Changsha, China.
FAU - Ma, Yuchao
AU  - Ma Y
AD  - Department of Cardio-Thoracic Surgery, Second Xiangya Hospital of Central South 
      University Changsha, China.
FAU - Wu, Xianning
AU  - Wu X
AD  - Department of Cardio-Thoracic Surgery, Second Xiangya Hospital of Central South 
      University Changsha, China.
FAU - Jin, Longyu
AU  - Jin L
AD  - Department of Cardio-Thoracic Surgery, Third Xiangya Hospital of Central South 
      University Changsha, China.
FAU - Yu, Fenglei
AU  - Yu F
AD  - Department of Cardio-Thoracic Surgery, Second Xiangya Hospital of Central South 
      University Changsha, China.
LA  - eng
PT  - Journal Article
DEP - 20140102
PL  - Singapore
TA  - Thorac Cancer
JT  - Thoracic cancer
JID - 101531441
PMC - PMC4704281
OTO - NOTNLM
OT  - Clinical stage
OT  - hepcidin
OT  - non-small cell lung cancer
EDAT- 2014/01/01 00:00
MHDA- 2014/01/01 00:01
PMCR- 2014/01/01
CRDT- 2016/01/15 06:00
PHST- 2013/03/02 00:00 [received]
PHST- 2013/04/04 00:00 [accepted]
PHST- 2016/01/15 06:00 [entrez]
PHST- 2014/01/01 00:00 [pubmed]
PHST- 2014/01/01 00:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.1111/1759-7714.12046 [doi]
PST - ppublish
SO  - Thorac Cancer. 2014 Jan;5(1):14-24. doi: 10.1111/1759-7714.12046. Epub 2014 Jan 
      2.