PMID- 26767610 OWN - NLM STAT- MEDLINE DCOM- 20161114 LR - 20240117 IS - 1532-429X (Electronic) IS - 1097-6647 (Print) IS - 1097-6647 (Linking) VI - 18 DP - 2016 Jan 14 TI - Microvascular ischemia in hypertrophic cardiomyopathy: new insights from high-resolution combined quantification of perfusion and late gadolinium enhancement. PG - 4 LID - 10.1186/s12968-016-0223-8 [doi] LID - 4 AB - BACKGROUND: Microvascular ischemia is one of the hallmarks of hypertrophic cardiomyopathy (HCM) and has been associated with poor outcome. However, myocardial fibrosis, seen on cardiovascular magnetic resonance (CMR) as late gadolinium enhancement (LGE), can be responsible for rest perfusion defects in up to 30% of patients with HCM, potentially leading to an overestimation of the ischemic burden. We investigated the effect of left ventricle (LV) scar on the total LV ischemic burden using novel high-resolution perfusion analysis techniques in conjunction with LGE quantification. METHODS: 30 patients with HCM and unobstructed epicardial coronary arteries underwent CMR with Fermi constrained quantitative perfusion analysis on segmental and high-resolution data. The latter were corrected for the presence of fibrosis on a pixel-by-pixel basis. RESULTS: High-resolution quantification proved more sensitive for the detection of microvascular ischemia in comparison to segmental analysis. Areas of LGE were associated with significant reduction of myocardial perfusion reserve (MPR) leading to an overestimation of the total ischemic burden on non-corrected perfusion maps. Using a threshold MPR of 1.5, the presence of LGE caused an overestimation of the ischemic burden of 28%. The ischemic burden was more severe in patients with fibrosis, also after correction of the perfusion maps, in keeping with more severe disease in this subgroup. CONCLUSIONS: LGE is an important confounder in the assessment of the ischemic burden in patients with HCM. High-resolution quantitative analysis with LGE correction enables the independent evaluation of microvascular ischemia and fibrosis and should be used when evaluating patients with HCM. FAU - Villa, Adriana D M AU - Villa AD AD - Division of Imaging Sciences, King's College London, Wellcome Trust/EPSRC Medical Engineering Centre, St Thomas' Hospital, London, UK. adriana.villa@kcl.ac.uk. FAU - Sammut, Eva AU - Sammut E AD - Division of Imaging Sciences, King's College London, Wellcome Trust/EPSRC Medical Engineering Centre, St Thomas' Hospital, London, UK. eva.sammut@kcl.ac.uk. FAU - Zarinabad, Niloufar AU - Zarinabad N AD - Division of Imaging Sciences, King's College London, Wellcome Trust/EPSRC Medical Engineering Centre, St Thomas' Hospital, London, UK. niloufar.zarinabad@kcl.ac.uk. FAU - Carr-White, Gerald AU - Carr-White G AD - Cardiology Department, St Thomas' Hospital, London, UK. gerry.carr-white@gstt.nhs.uk. FAU - Lee, Jack AU - Lee J AD - Division of Imaging Sciences, King's College London, Wellcome Trust/EPSRC Medical Engineering Centre, St Thomas' Hospital, London, UK. jack.lee@kcl.ac.uk. FAU - Bettencourt, Nuno AU - Bettencourt N AD - Hospital Center Vila Nova Gaia, Porto, Portugal. bettencourt.n@gmail.com. FAU - Razavi, Reza AU - Razavi R AD - Division of Imaging Sciences, King's College London, Wellcome Trust/EPSRC Medical Engineering Centre, St Thomas' Hospital, London, UK. reza.razavi@kcl.ac.uk. FAU - Nagel, Eike AU - Nagel E AD - DZHK Centre for Cardiovascular Imaging, University Hospital Frankfurt / Main, Frankfurt am Main, Germany. eike.nagel@cardiac-imaging.org. FAU - Chiribiri, Amedeo AU - Chiribiri A AD - Division of Imaging Sciences, King's College London, Wellcome Trust/EPSRC Medical Engineering Centre, St Thomas' Hospital, London, UK. amedeo.chiribiri@kcl.ac.uk. AD - Division of Imaging Sciences and Biomedical Engineering, King's College London, The Rayne Institute - 4th Floor Lambeth Wing, St Thomas' Hospital, SE1 7EH, London, UK. amedeo.chiribiri@kcl.ac.uk. LA - eng GR - Wellcome Trust/United Kingdom GR - RE/08/003/BHF_/British Heart Foundation/United Kingdom GR - WT 088641/Z/09/Z/WT_/Wellcome Trust/United Kingdom PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20160114 PL - England TA - J Cardiovasc Magn Reson JT - Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance JID - 9815616 RN - 0 (Contrast Media) RN - 0 (Organometallic Compounds) RN - 1BJ477IO2L (gadobutrol) SB - IM MH - Aged MH - Cardiomyopathy, Hypertrophic/*diagnosis/pathology/physiopathology MH - Cicatrix/*diagnosis/pathology/physiopathology MH - *Contrast Media MH - *Coronary Circulation MH - Feasibility Studies MH - Female MH - Fibrosis MH - Humans MH - Hyperemia/physiopathology MH - *Magnetic Resonance Imaging MH - Male MH - *Microcirculation MH - Middle Aged MH - Myocardial Ischemia/*diagnosis/pathology/physiopathology MH - Myocardial Perfusion Imaging/*methods MH - Myocardium/*pathology MH - *Organometallic Compounds MH - Predictive Value of Tests MH - Reproducibility of Results MH - Retrospective Studies PMC - PMC4714488 EDAT- 2016/01/16 06:00 MHDA- 2016/11/15 06:00 PMCR- 2016/01/14 CRDT- 2016/01/16 06:00 PHST- 2015/10/10 00:00 [received] PHST- 2016/01/05 00:00 [accepted] PHST- 2016/01/16 06:00 [entrez] PHST- 2016/01/16 06:00 [pubmed] PHST- 2016/11/15 06:00 [medline] PHST- 2016/01/14 00:00 [pmc-release] AID - S1097-6647(23)00945-6 [pii] AID - 223 [pii] AID - 10.1186/s12968-016-0223-8 [doi] PST - epublish SO - J Cardiovasc Magn Reson. 2016 Jan 14;18:4. doi: 10.1186/s12968-016-0223-8.