PMID- 26768192
OWN - NLM
STAT- MEDLINE
DCOM- 20180205
LR  - 20220317
IS  - 1365-2982 (Electronic)
IS  - 1350-1925 (Linking)
VI  - 28
IP  - 5
DP  - 2016 May
TI  - Predictors of proton pump inhibitor failure in non-erosive reflux disease: A 
      study with impedance-pH monitoring and high-resolution manometry.
PG  - 674-9
LID - 10.1111/nmo.12763 [doi]
AB  - BACKGROUND: Approximately one-third of gastroesophageal reflux disease (GERD) 
      patients have symptoms resistant to proton pump inhibitor (PPI). We used the 
      high-resolution manometry (HRM) and multichannel intraluminal impedance-pH 
      (MII-pH) monitoring to investigate potential predictors of PPI failure in 
      non-erosive reflux disease (NERD) patients. METHODS: One hundred and seventeen 
      NERD patients were included, within which there were 44 PPI failure patients. The 
      symptomatic questionnaire GerdQ, HRM and 24-hour MII-pH monitoring were performed 
      before PPI therapy. PPI failure was defined as persistent reflux symptoms for 
      more than 1 day during the last week on esomeprazole (20 mg twice daily) for 
      continuous 4 weeks. The predictors for PPI failure were investigated by 
      multivariable logistic regression analysis. KEY RESULTS: Proton pump inhibitor 
      failure patients had lower body mass index (BMI) and more concomitant functional 
      dyspepsia (FD) symptoms. PPI failure patients had a higher percentage of type I 
      esophagogastric junction (EGJ) morphology (p = 0.005), increased EGJ augmentation 
      (p = 0.000), higher prevalence of esophageal motility disorders (p = 0.005) and a 
      higher ratio of negative symptom index (SI, p = 0.000). Multivariable regression 
      analysis showed that concomitance of FD symptoms, EGJ augmentation and negative 
      SI were independent risk factors for PPI failure in NERD. CONCLUSIONS & 
      INFERENCES: Approximately half of PPI failure patients were found to have 
      esophageal motility disorders in HRM. The independent risk factors for PPI 
      failure in NERD were concomitant FD symptoms, increased EGJ augmentation and 
      negative SI.
CI  - (c) 2016 John Wiley & Sons Ltd.
FAU - Shi, Y
AU  - Shi Y
AD  - Department of Gastroenterology and Hepatology, The First Affiliated Hospital of 
      Sun Yat-Sen University, Guangzhou, Guangdong Province, China.
AD  - Department of Gastroenterology, Shanxi Cancer Hospital, Taiyuan, Shanxi Province, 
      China.
FAU - Tan, N
AU  - Tan N
AD  - Department of Gastroenterology and Hepatology, The First Affiliated Hospital of 
      Sun Yat-Sen University, Guangzhou, Guangdong Province, China.
FAU - Zhang, N
AU  - Zhang N
AD  - Department of Gastroenterology and Hepatology, The First Affiliated Hospital of 
      Sun Yat-Sen University, Guangzhou, Guangdong Province, China.
FAU - Xiong, L
AU  - Xiong L
AD  - Department of Gastroenterology and Hepatology, The First Affiliated Hospital of 
      Sun Yat-Sen University, Guangzhou, Guangdong Province, China.
FAU - Peng, S
AU  - Peng S
AD  - Department of Gastroenterology and Hepatology, The First Affiliated Hospital of 
      Sun Yat-Sen University, Guangzhou, Guangdong Province, China.
FAU - Lin, J
AU  - Lin J
AD  - Department of Gastroenterology and Hepatology, The First Affiliated Hospital of 
      Sun Yat-Sen University, Guangzhou, Guangdong Province, China.
FAU - Chen, M
AU  - Chen M
AD  - Department of Gastroenterology and Hepatology, The First Affiliated Hospital of 
      Sun Yat-Sen University, Guangzhou, Guangdong Province, China.
FAU - Xiao, Y
AU  - Xiao Y
AD  - Department of Gastroenterology and Hepatology, The First Affiliated Hospital of 
      Sun Yat-Sen University, Guangzhou, Guangdong Province, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160114
PL  - England
TA  - Neurogastroenterol Motil
JT  - Neurogastroenterology and motility
JID - 9432572
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Adult
MH  - Esophageal pH Monitoring/*methods
MH  - Female
MH  - Gastroesophageal Reflux/diagnosis/*drug therapy/*physiopathology
MH  - Humans
MH  - Male
MH  - Manometry/*methods
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Treatment Failure
OTO - NOTNLM
OT  - HRM
OT  - PPI failure
OT  - impedance-pH monitoring
OT  - nerd
EDAT- 2016/01/16 06:00
MHDA- 2018/02/06 06:00
CRDT- 2016/01/16 06:00
PHST- 2015/06/05 00:00 [received]
PHST- 2015/11/27 00:00 [accepted]
PHST- 2016/01/16 06:00 [entrez]
PHST- 2016/01/16 06:00 [pubmed]
PHST- 2018/02/06 06:00 [medline]
AID - 10.1111/nmo.12763 [doi]
PST - ppublish
SO  - Neurogastroenterol Motil. 2016 May;28(5):674-9. doi: 10.1111/nmo.12763. Epub 2016 
      Jan 14.