PMID- 26768918
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20181113
IS  - 1476-5454 (Electronic)
IS  - 0950-222X (Print)
IS  - 0950-222X (Linking)
VI  - 30
IP  - 4
DP  - 2016 Apr
TI  - Is optical coherence tomography an effective device for evaluation of tear film 
      meniscus in patients with acne rosacea?
PG  - 545-52
LID - 10.1038/eye.2015.277 [doi]
AB  - PURPOSE: To investigate the tear meniscus using Fourier-domain optical coherence 
      tomography (FD-OCT) in patients with acne rosacea and to determine the 
      relationship between tear film break-up tests (TBUT), Schirmer test and FD-OCT 
      values and to compare them with that of healthy controls. METHODS: One hundred 
      and four patients with acne rosacea and 104 body mass index age-sex-matched 
      healthy subjects were enrolled in this prospective case-control study. Tear 
      meniscus height (TMH), tear meniscus depth (TMD), and tear meniscus 
      cross-sectional area (TMA) were measured using FD-OCT (RTVue-100); TBUT, Schirmer 
      test and dry eye questionnaire (OSDI) were evaluated. Correlation was assessed 
      using Spearman's correlation coefficient. RESULTS: Mean TMH, TMD, TMA, TBUT, and 
      Schirmer test values of acne rosacea patients were significantly lower than and 
      OSDI score significantly higher than those of controls. Tear mensicus values were 
      significantly correlated with OSDI scores, TBUT, and Schirmer test results. The 
      intraobserver intraclass correlation coefficient (ICC) for tear parameters ranged 
      from 0.90 to 0.96 and interobserver ICC ranged from 0.92 to 0.94, which revealed 
      high reproducibility for all measurements parameters both acne rosacea and 
      control subjects. Accuracy of dry eye diagnosis by FD-OCT was 60.4% for TMH, 
      58.7% for TMD, and 64.8% for TMA. CONCLUSION: Tear meniscus measurement with 
      FD-OCT could provide acceptable specificity and sensitivity in diagnosis of dry 
      eye in acne rosacea patients.
FAU - Eroglu, F C
AU  - Eroglu FC
AD  - Department of Ophthalmology, Sereflikochisar State Hospital, Ankara, Turkey.
FAU - Karalezli, A
AU  - Karalezli A
AD  - Department of Ophthalmology, Baskent University School of Medicine, Konya, 
      Turkey.
FAU - Dursun, R
AU  - Dursun R
AD  - Department of Dermatology, Baskent University School of Medicine, Konya, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20160115
PL  - England
TA  - Eye (Lond)
JT  - Eye (London, England)
JID - 8703986
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Dry Eye Syndromes/*diagnosis/metabolism
MH  - Female
MH  - Fourier Analysis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Reproducibility of Results
MH  - Rosacea/*diagnosis/metabolism
MH  - Sensitivity and Specificity
MH  - Surveys and Questionnaires
MH  - Tears/*physiology
MH  - *Tomography, Optical Coherence
PMC - PMC5108538
EDAT- 2016/01/16 06:00
MHDA- 2016/12/15 06:00
PMCR- 2017/04/01
CRDT- 2016/01/16 06:00
PHST- 2015/04/08 00:00 [received]
PHST- 2015/11/13 00:00 [accepted]
PHST- 2016/01/16 06:00 [entrez]
PHST- 2016/01/16 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
PHST- 2017/04/01 00:00 [pmc-release]
AID - eye2015277 [pii]
AID - 10.1038/eye.2015.277 [doi]
PST - ppublish
SO  - Eye (Lond). 2016 Apr;30(4):545-52. doi: 10.1038/eye.2015.277. Epub 2016 Jan 15.