PMID- 26769754
OWN - NLM
STAT- MEDLINE
DCOM- 20170630
LR  - 20171215
IS  - 1758-1052 (Electronic)
IS  - 0956-4624 (Linking)
VI  - 27
IP  - 11
DP  - 2016 Oct
TI  - Steroid-exacerbated HIV-associated cutaneous Kaposi's sarcoma immune 
      reconstitution inflammatory syndrome: 'Where a good intention turns bad'.
PG  - 1026-9
LID - 10.1177/0956462415627735 [doi]
AB  - A 51-year-old man with head and neck skin lesions was diagnosed with Kaposi's 
      sarcoma (KS) as his initial presentation of acquired immunodeficiency syndrome. 
      Following initiation of antiretroviral therapy and subsequent full virologic 
      suppression, his facial lesions worsened, consistent with immune reconstitution 
      inflammatory syndrome (IRIS). He was started on glucocorticoids in an attempt to 
      ameliorate the KS-IRIS but experienced paradoxical worsening of the KS lesions. 
      Steroids were subsequently discontinued and he required chemotherapy for severe 
      and cosmetically disfiguring skin lesions. This article describes the potential 
      for worsening of KS lesions in individuals started on glucocorticoids for KS-IRIS 
      as this has been reported rarely in published literature. The mechanisms 
      underlying this phenomenon remain poorly understood but potential explanations 
      are offered in the case discussion. This article aims to raise clinician 
      awareness on the harms of steroid use in patients with KS-IRIS.
CI  - (c) The Author(s) 2016.
FAU - Chabria, Shiven
AU  - Chabria S
AD  - Department of Medicine, Waterbury Hospital, Waterbury, CT, USA.
FAU - Barakat, Lydia
AU  - Barakat L
AD  - Yale AIDS Program, Section of Infectious Diseases, Yale University School of 
      Medicine, New Haven, CT, USA.
FAU - Ogbuagu, Onyema
AU  - Ogbuagu O
AD  - Yale AIDS Program, Section of Infectious Diseases, Yale University School of 
      Medicine, New Haven, CT, USA onyema.ogbuagu@yale.edu.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20160113
PL  - England
TA  - Int J STD AIDS
JT  - International journal of STD & AIDS
JID - 9007917
RN  - 0 (Steroids)
SB  - IM
MH  - AIDS-Related Opportunistic Infections/*drug therapy/immunology
MH  - Acquired Immunodeficiency Syndrome/complications/*drug therapy
MH  - *Antiretroviral Therapy, Highly Active
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*drug therapy
MH  - Male
MH  - Middle Aged
MH  - Sarcoma, Kaposi/*complications/immunology/pathology
MH  - Skin/pathology
MH  - Steroids/adverse effects/*therapeutic use
MH  - Treatment Outcome
OTO - NOTNLM
OT  - AIDS
OT  - HIV
OT  - IRIS
OT  - Kaposi's sarcoma
OT  - opportunistic infection
OT  - steroids
EDAT- 2016/01/16 06:00
MHDA- 2017/07/01 06:00
CRDT- 2016/01/16 06:00
PHST- 2015/11/18 00:00 [received]
PHST- 2015/12/22 00:00 [accepted]
PHST- 2016/01/16 06:00 [entrez]
PHST- 2016/01/16 06:00 [pubmed]
PHST- 2017/07/01 06:00 [medline]
AID - 0956462415627735 [pii]
AID - 10.1177/0956462415627735 [doi]
PST - ppublish
SO  - Int J STD AIDS. 2016 Oct;27(11):1026-9. doi: 10.1177/0956462415627735. Epub 2016 
      Jan 13.