PMID- 26770987 OWN - NLM STAT- MEDLINE DCOM- 20161005 LR - 20220316 IS - 2314-6753 (Electronic) IS - 2314-6745 (Print) VI - 2016 DP - 2016 TI - Nutrition and Physical Activity in Nonalcoholic Fatty Liver Disease. PG - 4597246 LID - 10.1155/2016/4597246 [doi] LID - 4597246 AB - Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide and it is associated with other medical conditions such as diabetes mellitus, metabolic syndrome, and obesity. The mechanisms of the underlying disease development and progression are not completely established and there is no consensus concerning the pharmacological treatment. In the gold standard treatment for NAFLD weight loss, dietary therapy, and physical activity are included. However, little scientific evidence is available on diet and/or physical activity and NAFLD specifically. Many dietary approaches such as Mediterranean and DASH diet are used for treatment of other cardiometabolic risk factors such as insulin resistance and type-2 diabetes mellitus (T2DM), but on the basis of its components their role in NAFLD has been discussed. In this review, the implications of current dietary and exercise approaches, including Brazilian and other guidelines, are discussed, with a focus on determining the optimal nonpharmacological treatment to prescribe for NAFLD. FAU - Oliveira, Claudia P AU - Oliveira CP AD - Department of Gastroenterology, School of Medicine, University of Sao Paulo (USP), 255 Dr. Eneas de Carvalho Aguiar Avenue, Cerqueira Cesar, 05403-900 Sao Paulo, SP, Brazil. FAU - de Lima Sanches, Priscila AU - de Lima Sanches P AD - Postgraduate Program in Nutrition, Federal University of Sao Paulo (UNIFESP), 630 Marselhesa Street, Vila Clementino, 04020-060 Sao Paulo, SP, Brazil. FAU - de Abreu-Silva, Erlon Oliveira AU - de Abreu-Silva EO AD - Division of Interventional Cardiology and Postgraduate Program in Cardiology, Federal University of Sao Paulo (UNIFESP), 715 Napoleao de Barros Street, Vila Clementino, 04024-002 Sao Paulo, SP, Brazil. FAU - Marcadenti, Aline AU - Marcadenti A AD - Department of Nutrition, Federal University of Health Sciences of Porto Alegre (UFCSPA), 245 Sarmento Leite Street, Centro Historico, 90050-170 Porto Alegre, RS, Brazil; Postgraduate Program in Health Sciences: Cardiology, Institute of Cardiology of Rio Grande do Sul (IC/FUC), 395 Princesa Isabel Avenue, Santana, 90040-371 Porto Alegre, RS, Brazil. LA - eng PT - Journal Article PT - Review DEP - 20151207 PL - England TA - J Diabetes Res JT - Journal of diabetes research JID - 101605237 SB - IM MH - *Diet MH - Exercise/*physiology MH - Humans MH - Insulin Resistance/*physiology MH - Motor Activity/physiology MH - Non-alcoholic Fatty Liver Disease/*physiopathology/*therapy MH - Nutritional Status PMC - PMC4685119 EDAT- 2016/01/16 06:00 MHDA- 2016/10/07 06:00 PMCR- 2015/12/07 CRDT- 2016/01/16 06:00 PHST- 2015/03/29 00:00 [received] PHST- 2015/07/26 00:00 [revised] PHST- 2015/07/29 00:00 [accepted] PHST- 2016/01/16 06:00 [entrez] PHST- 2016/01/16 06:00 [pubmed] PHST- 2016/10/07 06:00 [medline] PHST- 2015/12/07 00:00 [pmc-release] AID - 10.1155/2016/4597246 [doi] PST - ppublish SO - J Diabetes Res. 2016;2016:4597246. doi: 10.1155/2016/4597246. Epub 2015 Dec 7.