PMID- 26772434
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20161230
IS  - 1879-0542 (Electronic)
IS  - 0165-2478 (Linking)
VI  - 171
DP  - 2016 Mar
TI  - The discovery of immunoglobulin E.
PG  - 1-4
LID - S0165-2478(16)30001-3 [pii]
LID - 10.1016/j.imlet.2016.01.001 [doi]
AB  - The discovery of immunoglobulin E (IgE) was a breakthrough in the field of 
      allergy and immunology. Our understanding of mechanisms of allergic reactions and 
      the role of IgE in these disorders has paralleled to the discovery of treatment 
      modalities for patients with allergy. The first clue to the existence of a 
      substance responsible for hypersensitivity reactions was demonstrated in 1921 by 
      Prausnitz and Kustner, and after four decades it was identified as an 
      immunoglobulin subclass by Ishizakas and co-workers. In 1968, the WHO 
      International Reference Centre for Immunoglobulins announced the presence of a 
      fifth immunoglobulin isotype, IgE.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Ribatti, Domenico
AU  - Ribatti D
AD  - Department of Basic Medical Sciences, Neurosciences and Sensory Organs, 
      University of Bari Medical School, Bari, Italy; National Cancer Institute 
      "Giovanni Paolo II", Bari, Italy. Electronic address: domenico.ribatti@uniba.it.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Review
DEP - 20160106
PL  - Netherlands
TA  - Immunol Lett
JT  - Immunology letters
JID - 7910006
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergy and Immunology/*history
MH  - Anaphylaxis/*immunology
MH  - Animals
MH  - Biomedical Research
MH  - History, 20th Century
MH  - Humans
MH  - Hypersensitivity/*immunology
MH  - Immunoglobulin E/*immunology
MH  - Nobel Prize
MH  - World Health Organization
OTO - NOTNLM
OT  - Allergic reactions
OT  - Anaphylaxis
OT  - History of immunology
OT  - IgE
EDAT- 2016/01/17 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/01/17 06:00
PHST- 2015/12/09 00:00 [received]
PHST- 2015/12/30 00:00 [revised]
PHST- 2016/01/02 00:00 [accepted]
PHST- 2016/01/17 06:00 [entrez]
PHST- 2016/01/17 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - S0165-2478(16)30001-3 [pii]
AID - 10.1016/j.imlet.2016.01.001 [doi]
PST - ppublish
SO  - Immunol Lett. 2016 Mar;171:1-4. doi: 10.1016/j.imlet.2016.01.001. Epub 2016 Jan 
      6.