PMID- 26772533
OWN - NLM
STAT- MEDLINE
DCOM- 20160601
LR  - 20220129
IS  - 1365-229X (Electronic)
IS  - 0009-9260 (Print)
IS  - 0009-9260 (Linking)
VI  - 71
IP  - 3
DP  - 2016 Mar
TI  - Acute myocardial infarction: susceptibility-weighted cardiac MRI for the 
      detection of reperfusion haemorrhage at 1.5 T.
PG  - e150-6
LID - S0009-9260(15)00493-6 [pii]
LID - 10.1016/j.crad.2015.12.008 [doi]
AB  - AIM: To assess whether susceptibility-weighted imaging (SWI) provides better 
      image contrast for the detection of haemorrhagic ischaemia-reperfusion injury in 
      the heart. MATERIALS AND METHODS: Thirty patients (all men; mean age 53 years) 
      underwent cardiac magnetic resonance imaging (MRI) within 7 days of primary 
      percutaneous intervention for acute ST elevation myocardial infarction (STEMI). 
      Multiple gradient-echo T2* sequences with magnitude and phase reconstructions 
      were acquired. A high-pass filtered phase map was used to create a mask for the 
      SWI reconstructions. The difference in image contrast was assessed in those 
      patients with microvascular obstruction. A mixed effects regression model was 
      used to test the effect of echo time and reconstruction method on phase and 
      contrast-to-noise ratio (CNR). Medians and interquartile ranges (IQR) are 
      reported. RESULTS: T2* in haemorrhagic infarcts was shorter than in 
      non-haemorrhagic infarcts (33.5 ms [24.9-43] versus 49.9 ms [44.6-67.6]; 
      p=0.0007). The effect of echo time on phase was significant (p<0.0001), as was 
      the effect of haemorrhage on phase (p=0.0016). SWI reconstruction had a 
      significant effect on the CNR at all echo times (echoes 1-5, p<0.0001; echo 6, 
      p=0.01; echo 7, p=0.02). The median echo number at which haemorrhage was first 
      visible was less for SWI compared to source images (echo 2 versus echo 5, 
      p=0.0002). CONCLUSION: Cardiac SWI improves the contrast between myocardial 
      haemorrhage and the surrounding tissue following STEMI and has potential as a new 
      tool for identifying patients with ischaemia-reperfusion injury.
CI  - Copyright (c) 2015 The Royal College of Radiologists. Published by Elsevier Ltd. 
      All rights reserved.
FAU - Durighel, G
AU  - Durighel G
AD  - Robert Steiner MRI Unit, MRC Clinical Sciences Centre, Imperial College London, 
      Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.
FAU - Tokarczuk, P F
AU  - Tokarczuk PF
AD  - Robert Steiner MRI Unit, MRC Clinical Sciences Centre, Imperial College London, 
      Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.
FAU - Karsa, A
AU  - Karsa A
AD  - Department of Physics, Budapest University of Technology and Economics, Budapest, 
      Hungary.
FAU - Gordon, F
AU  - Gordon F
AD  - Statistical Advisory Service, School of Public Health, Imperial College, London 
      W12 1PG, UK.
FAU - Cook, S A
AU  - Cook SA
AD  - Robert Steiner MRI Unit, MRC Clinical Sciences Centre, Imperial College London, 
      Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK; Department of 
      Cardiology, Imperial College Healthcare NHS Trust, London, UK; Hammersmith 
      Hospital, Du Cane Road, London W12 0HS, UK; Department of Cardiology, National 
      Heart Centre Singapore, 17 Third Hospital Ave, Singapore 168752, Singapore; 
      Duke-NUS Graduate Medical School, 8 College Road, 169857, Singapore.
FAU - O'Regan, D P
AU  - O'Regan DP
AD  - Robert Steiner MRI Unit, MRC Clinical Sciences Centre, Imperial College London, 
      Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK. Electronic 
      address: declan.oregan@imperial.ac.uk.
LA  - eng
GR  - MC_U120085815/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160106
PL  - England
TA  - Clin Radiol
JT  - Clinical radiology
JID - 1306016
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
RN  - XM0M87F357 (Ferrosoferric Oxide)
SB  - IM
MH  - Cardiac-Gated Imaging Techniques/*methods
MH  - Contrast Media
MH  - Ferrosoferric Oxide
MH  - Gadolinium DTPA
MH  - Hemorrhage/*diagnosis/*etiology
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*therapy
MH  - Myocardial Reperfusion/*adverse effects
MH  - Percutaneous Coronary Intervention
MH  - Phantoms, Imaging
MH  - Prospective Studies
PMC - PMC5724752
MID - EMS75105
EDAT- 2016/01/17 06:00
MHDA- 2016/06/02 06:00
PMCR- 2017/12/11
CRDT- 2016/01/17 06:00
PHST- 2015/09/01 00:00 [received]
PHST- 2015/11/19 00:00 [revised]
PHST- 2015/12/14 00:00 [accepted]
PHST- 2016/01/17 06:00 [entrez]
PHST- 2016/01/17 06:00 [pubmed]
PHST- 2016/06/02 06:00 [medline]
PHST- 2017/12/11 00:00 [pmc-release]
AID - S0009-9260(15)00493-6 [pii]
AID - 10.1016/j.crad.2015.12.008 [doi]
PST - ppublish
SO  - Clin Radiol. 2016 Mar;71(3):e150-6. doi: 10.1016/j.crad.2015.12.008. Epub 2016 
      Jan 6.