PMID- 26773728
OWN - NLM
STAT- MEDLINE
DCOM- 20161104
LR  - 20181202
IS  - 1872-8057 (Electronic)
IS  - 0303-7207 (Linking)
VI  - 423
DP  - 2016 Mar 5
TI  - Rosiglitazone pretreatment protects against lipopolysaccharide-induced fetal 
      demise through inhibiting placental inflammation.
PG  - 51-9
LID - S0303-7207(16)30004-1 [pii]
LID - 10.1016/j.mce.2016.01.004 [doi]
AB  - Peroxisome proliferator-activated receptor (PPAR)-gamma is highly expressed in human 
      and rodent placentas. Nevertheless, its function remains obscure. The present 
      study investigated the effects of rosiglitazone, a PPAR-gamma agonist, on LPS-induced 
      fetal death. All pregnant mice except controls were intraperitoneally injected 
      with LPS (150 mug/kg) daily from gestational day (GD)15 to GD17. As expected, 
      maternal LPS injection caused placental inflammation and resulted in 63.6% fetal 
      death in dams that completed the pregnancy. Interestingly, LPS-induced fetal 
      mortality was reduced to 16.0% when pregnant mice were pretreated with RSG. 
      Additional experiment showed that rosiglitazone pretreatment inhibited 
      LPS-induced expressions of tumor necrosis factor (Tnf)-alpha, interleukin (Il)-1beta, 
      Il-6, macrophage inflammatory protein (Mip)-2 and keratinocyte-derived chemokine 
      (Kc) in mouse placenta. Although rosiglitazone had little effect on LPS-evoked 
      elevation of IL-10 in amniotic fluid, it alleviated LPS-evoked release of TNF-alpha 
      and MIP-2 in amniotic fluid. Further analysis showed that pretreatment with 
      rosiglitazone, which activated placental PPAR-gamma signaling, simultaneously 
      suppressed LPS-evoked nuclear factor kappa B (NF-kappaB) activation and blocked 
      nuclear translocation of NF-kappaB p65 and p50 subunits in trophoblast giant cells of 
      the labyrinth layer. These results provide a mechanistic explanation for 
      PPAR-gamma-mediated anti-inflammatory activity in the placentas. Overall, the present 
      study provides additional evidence for roles of PPAR-gamma as an important regulator 
      of placental inflammation.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Bo, Qing-Li
AU  - Bo QL
AD  - Department of Toxicology, School of Public Health, Anhui Medical University, 
      Hefei, 230032, China; Anhui Provincial Key Laboratory of Population Health & 
      Aristogenics, Hefei, 230032, China.
FAU - Chen, Yuan-Hua
AU  - Chen YH
AD  - Department of Toxicology, School of Public Health, Anhui Medical University, 
      Hefei, 230032, China; Anhui Provincial Key Laboratory of Population Health & 
      Aristogenics, Hefei, 230032, China; Department of Histology and Embryology, Anhui 
      Medical University, Hefei, 230032, China.
FAU - Yu, Zhen
AU  - Yu Z
AD  - Department of Toxicology, School of Public Health, Anhui Medical University, 
      Hefei, 230032, China; Anhui Provincial Key Laboratory of Population Health & 
      Aristogenics, Hefei, 230032, China.
FAU - Fu, Lin
AU  - Fu L
AD  - Department of Toxicology, School of Public Health, Anhui Medical University, 
      Hefei, 230032, China.
FAU - Zhou, Yan
AU  - Zhou Y
AD  - Department of Toxicology, School of Public Health, Anhui Medical University, 
      Hefei, 230032, China.
FAU - Zhang, Gui-Bin
AU  - Zhang GB
AD  - Department of Toxicology, School of Public Health, Anhui Medical University, 
      Hefei, 230032, China.
FAU - Wang, Hua
AU  - Wang H
AD  - Department of Toxicology, School of Public Health, Anhui Medical University, 
      Hefei, 230032, China; Anhui Provincial Key Laboratory of Population Health & 
      Aristogenics, Hefei, 230032, China.
FAU - Zhang, Zhi-Hui
AU  - Zhang ZH
AD  - Department of Toxicology, School of Public Health, Anhui Medical University, 
      Hefei, 230032, China.
FAU - Xu, De-Xiang
AU  - Xu DX
AD  - Department of Toxicology, School of Public Health, Anhui Medical University, 
      Hefei, 230032, China; Anhui Provincial Key Laboratory of Population Health & 
      Aristogenics, Hefei, 230032, China. Electronic address: xudex@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160108
PL  - Ireland
TA  - Mol Cell Endocrinol
JT  - Molecular and cellular endocrinology
JID - 7500844
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Chemokines)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (NF-kappa B)
RN  - 0 (PPAR gamma)
RN  - 0 (Thiazolidinediones)
RN  - 05V02F2KDG (Rosiglitazone)
SB  - IM
MH  - Active Transport, Cell Nucleus
MH  - Animals
MH  - Anti-Inflammatory Agents/*administration & dosage
MH  - Chemokines/blood
MH  - Drug Evaluation, Preclinical
MH  - Female
MH  - Fetal Death/prevention & control
MH  - Lipopolysaccharides/*pharmacology
MH  - Male
MH  - Mice, Inbred ICR
MH  - NF-kappa B/metabolism
MH  - PPAR gamma/metabolism
MH  - Placenta/drug effects/*immunology/metabolism
MH  - Pregnancy
MH  - Rosiglitazone
MH  - Signal Transduction
MH  - Thiazolidinediones/*administration & dosage
OTO - NOTNLM
OT  - Fetal death
OT  - Inflammation
OT  - Lipopolysaccharide
OT  - Peroxisome proliferator-activated receptor-gamma
OT  - Rosiglitazone
EDAT- 2016/01/17 06:00
MHDA- 2016/11/05 06:00
CRDT- 2016/01/17 06:00
PHST- 2015/11/30 00:00 [received]
PHST- 2015/12/25 00:00 [revised]
PHST- 2016/01/06 00:00 [accepted]
PHST- 2016/01/17 06:00 [entrez]
PHST- 2016/01/17 06:00 [pubmed]
PHST- 2016/11/05 06:00 [medline]
AID - S0303-7207(16)30004-1 [pii]
AID - 10.1016/j.mce.2016.01.004 [doi]
PST - ppublish
SO  - Mol Cell Endocrinol. 2016 Mar 5;423:51-9. doi: 10.1016/j.mce.2016.01.004. Epub 
      2016 Jan 8.