PMID- 26773771
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20161230
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 31
DP  - 2016 Feb
TI  - meso-Dihydroguaiaretic acid attenuates airway inflammation and mucus 
      hypersecretion in an ovalbumin-induced murine model of asthma.
PG  - 239-47
LID - S1567-5769(15)30238-1 [pii]
LID - 10.1016/j.intimp.2015.12.033 [doi]
AB  - meso-Dihydroguaiaretic acid (MDGA), which is a dibenzylbutane lignin isolated 
      from the ethyl acetate fraction of Saururus chinensis, has various biological 
      activities, including anti-oxidative, anti-inflammatory, anti-bacterial, and 
      neuroprotective effects. However, no report has examined the potential 
      anti-asthmatic activity of MDGA. In this study, we evaluated the protective 
      effects of MDGA on asthmatic responses, particularly airway inflammation and 
      mucus hypersecretion in an ovalbumin (OVA)-induced murine model of asthma. 
      Intragastric administration of MDGA significantly lowered the productions of 
      interleukin (IL)-4, IL-5, IL-13, tumor necrosis-alpha (TNF-alpha), eotaxin, monocyte 
      chemoattractant protein-1 (MCP-1), vascular cell adhesion molecule-1 (VCAM-1), 
      and immunoglobulin (Ig)E in bronchoalveolar lavage fluid (BALF), plasma, or lung 
      tissues. Histological studies showed that MDGA inhibited OVA-induced inflammatory 
      cell infiltration and mucus production in the respiratory tract. Moreover, MDGA 
      markedly attenuated the OVA-induced activations of nuclear factor kappa B 
      (NF-kappaB), extracellular-signal-regulated kinases 1/2 (ERK1/2), and p38 
      mitogen-activated protein kinase (p38 MAPK). Together, these results suggest that 
      MDGA effectively inhibits airway inflammation and mucus hypersecretion by 
      downregulating the levels of T helper 2 (Th2) cytokines, chemokines, and adhesion 
      molecules, and inhibiting the activations of NF-kappaB and MAPKs.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Song, Ji-Won
AU  - Song JW
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Chungnam 
      National University, Daejeon, Republic of Korea.
FAU - Seo, Chang-Seob
AU  - Seo CS
AD  - K-herb Research Center, Korea Institute of Oriental Medicine, Daejeon, Republic 
      of Korea.
FAU - Cho, Eun-Sang
AU  - Cho ES
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Chungnam 
      National University, Daejeon, Republic of Korea.
FAU - Kim, Tae-In
AU  - Kim TI
AD  - College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea.
FAU - Won, Young-Suk
AU  - Won YS
AD  - Laboratory Animal Resource Center, Korea Research Institute of Bioscience and 
      Biotechnology, Chungbuk, Republic of Korea.
FAU - Kwon, Hyo-Jung
AU  - Kwon HJ
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Chungnam 
      National University, Daejeon, Republic of Korea.
FAU - Son, Jong-Keun
AU  - Son JK
AD  - College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea. 
      Electronic address: jkson@yu.ac.kr.
FAU - Son, Hwa-Young
AU  - Son HY
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Chungnam 
      National University, Daejeon, Republic of Korea. Electronic address: 
      hyson@cnu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160111
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Anti-Asthmatic Agents)
RN  - 0 (Ccl2 protein, mouse)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
RN  - 0 (Lignans)
RN  - 0 (NF-kappa B)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - 36469-60-0 (dihydroguaiaretic acid)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 6JKA7MAH9C (Guaiacol)
SB  - IM
MH  - Animals
MH  - Anti-Asthmatic Agents/*therapeutic use
MH  - Asthma/*drug therapy
MH  - Cell Movement/drug effects
MH  - Chemokine CCL2/metabolism
MH  - Cytokines/metabolism
MH  - Female
MH  - Guaiacol/*analogs & derivatives/therapeutic use
MH  - Humans
MH  - Immunoglobulin E/metabolism
MH  - Lignans/*therapeutic use
MH  - MAP Kinase Signaling System/drug effects
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - NF-kappa B/metabolism
MH  - Pneumonia/*drug therapy
MH  - Saururaceae/*immunology
MH  - Th2 Cells/immunology
MH  - Vascular Cell Adhesion Molecule-1/metabolism
OTO - NOTNLM
OT  - Asthma
OT  - IgE
OT  - MAPKs
OT  - NF-kappaB
OT  - Th2 cytokines
OT  - meso-Dihydroguaiaretic acid
EDAT- 2016/01/17 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/01/17 06:00
PHST- 2015/05/28 00:00 [received]
PHST- 2015/12/09 00:00 [revised]
PHST- 2015/12/22 00:00 [accepted]
PHST- 2016/01/17 06:00 [entrez]
PHST- 2016/01/17 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - S1567-5769(15)30238-1 [pii]
AID - 10.1016/j.intimp.2015.12.033 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2016 Feb;31:239-47. doi: 10.1016/j.intimp.2015.12.033. Epub 
      2016 Jan 11.