PMID- 26773935
OWN - NLM
STAT- MEDLINE
DCOM- 20160524
LR  - 20230131
IS  - 1532-8600 (Electronic)
IS  - 0026-0495 (Linking)
VI  - 65
IP  - 2
DP  - 2016 Feb
TI  - Facilitative glucose transporters: Implications for cancer detection, prognosis 
      and treatment.
PG  - 124-39
LID - S0026-0495(15)00299-1 [pii]
LID - 10.1016/j.metabol.2015.10.007 [doi]
AB  - It is long recognized that cancer cells display increased glucose uptake and 
      metabolism. In a rate-limiting step for glucose metabolism, the glucose 
      transporter (GLUT) proteins facilitate glucose uptake across the plasma membrane. 
      Fourteen members of the GLUT protein family have been identified in humans. This 
      review describes the major characteristics of each member of the GLUT family and 
      highlights evidence of abnormal expression in tumors and cancer cells. The 
      regulation of GLUTs by key proliferation and pro-survival pathways including the 
      phosphatidylinositol 3-kinase (PI3K)-Akt, hypoxia-inducible factor-1 (HIF-1), 
      Ras, c-Myc and p53 pathways is discussed. The clinical utility of GLUT expression 
      in cancer has been recognized and evidence regarding the use of GLUTs as 
      prognostic or predictive biomarkers is presented. GLUTs represent attractive 
      targets for cancer therapy and this review summarizes recent studies in which 
      GLUT1, GLUT3, GLUT5 and others are inhibited to decrease cancer growth.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Barron, Carly C
AU  - Barron CC
AD  - Department of Health Sciences, Brock University, St. Catharines, ON, L2S 3A1, 
      Canada.
FAU - Bilan, Philip J
AU  - Bilan PJ
AD  - Program in Cell Biology, Peter Gilgan Centre for Research and Learning, The 
      Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.
FAU - Tsakiridis, Theodoros
AU  - Tsakiridis T
AD  - Department of Oncology, and Department of Pathology and Molecular Medicine, 
      McMaster University, Hamilton, ON, L8S 4L8, Canada.
FAU - Tsiani, Evangelia
AU  - Tsiani E
AD  - Department of Health Sciences, Brock University, St. Catharines, ON, L2S 3A1, 
      Canada. Electronic address: ltsiani@brocku.ca.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20151113
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Glucose Transport Proteins, Facilitative)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
SB  - IM
MH  - Animals
MH  - Fluorodeoxyglucose F18
MH  - Glucose Transport Proteins, Facilitative/antagonists & 
      inhibitors/classification/*physiology
MH  - Humans
MH  - Neoplasms/*diagnosis/therapy
MH  - Prognosis
OTO - NOTNLM
OT  - Cancer metabolism
OT  - GLUT
OT  - Glucose transporter
OT  - SLC2
OT  - Warburg effect
EDAT- 2016/01/17 06:00
MHDA- 2016/05/25 06:00
CRDT- 2016/01/17 06:00
PHST- 2015/08/03 00:00 [received]
PHST- 2015/09/22 00:00 [revised]
PHST- 2015/10/01 00:00 [accepted]
PHST- 2016/01/17 06:00 [entrez]
PHST- 2016/01/17 06:00 [pubmed]
PHST- 2016/05/25 06:00 [medline]
AID - S0026-0495(15)00299-1 [pii]
AID - 10.1016/j.metabol.2015.10.007 [doi]
PST - ppublish
SO  - Metabolism. 2016 Feb;65(2):124-39. doi: 10.1016/j.metabol.2015.10.007. Epub 2015 
      Nov 13.