PMID- 26774870
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20161230
IS  - 1532-8511 (Electronic)
IS  - 1052-3057 (Linking)
VI  - 25
IP  - 3
DP  - 2016 Mar
TI  - Posterior Circulation Evaluation in Patients with Sickle Cell Anemia.
PG  - 717-21
LID - S1052-3057(15)00618-7 [pii]
LID - 10.1016/j.jstrokecerebrovasdis.2015.11.007 [doi]
AB  - BACKGROUND: The role of transcranial Doppler (TCD) ultrasonography in identifying 
      children with sickle cell anemia (SCA) at risk for stroke is well known; however, 
      the major studies that evaluated TCD velocities in children with SCA did not 
      report posterior circulation evaluation data. The objective of our study was to 
      describe the pattern of blood flow velocities in the posterior circulation of 
      patients with SCA and to examine their relationship with findings on magnetic 
      resonance imaging (MRI)/magnetic resonance angiography (MRA). METHODS: All adult 
      patients with SCA followed in the outpatient clinic of our hospital were 
      evaluated with TCD and MRI/MRA. The highest velocities of the middle cerebral 
      arteries or internal carotid arteries were taken as the time-averaged maximum 
      mean (TAMM) velocity for each patient and the maximum mean flow velocities in the 
      posterior circulation (TAMMpost) were recorded. RESULTS: Fifty-six patients with 
      SCA and 56 healthy nonanemic volunteers were evaluated. The mean TAMMpost in the 
      basilar, vertebral, and posterior cerebral arteries (PCAs) were significantly 
      higher among cases than controls (P < .01). In patients with SCA, the TAMMpost in 
      all posterior circulation arteries had a positive correlation with TAMM. Only 1 
      patient with stenosis in the posterior circulation (right PCA) was identified. 
      CONCLUSION: We found a low frequency of stenosis but high blood flow velocities 
      in the posterior circulation in patients with SCA. The role of increased TCD 
      velocities in the posterior circulation upon stroke risk in patients with SCA 
      should be further examined.
CI  - Copyright (c) 2016 National Stroke Association. Published by Elsevier Inc. All 
      rights reserved.
FAU - Adegoke, Samuel Ademola
AU  - Adegoke SA
AD  - Department of Pediatrics and Child Health, Obafemi Awolowo University, Ile-Ife, 
      Nigeria; Department of Hematology, UNIFESP, Sao Paulo, SP, Brazil.
FAU - Figueiredo, Maria Stella
AU  - Figueiredo MS
AD  - Department of Hematology, UNIFESP, Sao Paulo, SP, Brazil.
FAU - Vicari, Perla
AU  - Vicari P
AD  - Department of Hematology, UNIFESP, Sao Paulo, SP, Brazil.
FAU - Carrete, Henrique Jr
AU  - Carrete H Jr
AD  - Department of Radiology, UNIFESP, Sao Paulo, SP, Brazil.
FAU - Idagawa, Marcos Hideki
AU  - Idagawa MH
AD  - Department of Radiology, UNIFESP, Sao Paulo, SP, Brazil.
FAU - Massaro, Ayrton Roberto
AU  - Massaro AR
AD  - Hospital Sirio-Libanes, Sao Paulo, SP, Brazil.
FAU - Silva, Gisele Sampaio
AU  - Silva GS
AD  - Department of Neurology and Neurosurgery, UNIFESP, Sao Paulo, SP, Brazil; 
      Programa Integrado de Neurologia, Hospital Israelita Albert Einstein, Sao Paulo, 
      SP, Brazil. Electronic address: giselesampaio@hotmail.com.
LA  - eng
PT  - Journal Article
DEP - 20160108
PL  - United States
TA  - J Stroke Cerebrovasc Dis
JT  - Journal of stroke and cerebrovascular diseases : the official journal of National 
      Stroke Association
JID - 9111633
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anemia, Sickle Cell/diagnostic imaging/*physiopathology
MH  - Blood Flow Velocity/physiology
MH  - Case-Control Studies
MH  - Cerebrovascular Circulation/*physiology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Angiography
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Outpatients
MH  - Statistics as Topic
MH  - Ultrasonography, Doppler, Transcranial
MH  - Young Adult
OTO - NOTNLM
OT  - Sickle cell anemia
OT  - intracranial stenoses
OT  - magnetic resonance imaging
OT  - posterior circulation
OT  - stroke
OT  - transcranial Doppler
EDAT- 2016/01/18 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/01/18 06:00
PHST- 2015/05/18 00:00 [received]
PHST- 2015/09/08 00:00 [revised]
PHST- 2015/11/05 00:00 [accepted]
PHST- 2016/01/18 06:00 [entrez]
PHST- 2016/01/18 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - S1052-3057(15)00618-7 [pii]
AID - 10.1016/j.jstrokecerebrovasdis.2015.11.007 [doi]
PST - ppublish
SO  - J Stroke Cerebrovasc Dis. 2016 Mar;25(3):717-21. doi: 
      10.1016/j.jstrokecerebrovasdis.2015.11.007. Epub 2016 Jan 8.