PMID- 26774873
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20191210
IS  - 1532-8511 (Electronic)
IS  - 1052-3057 (Linking)
VI  - 25
IP  - 3
DP  - 2016 Mar
TI  - Predicting the Outcomes of Acute Ischemic Stroke with Rheumatic Heart Disease: 
      The Values of CHADS2, CHA2DS2-VASc, and HAS-BLED Scores.
PG  - 722-6
LID - S1052-3057(15)00489-9 [pii]
LID - 10.1016/j.jstrokecerebrovasdis.2015.09.003 [doi]
AB  - BACKGROUND AND OBJECTIVE: The CHADS2 and CHA2DS2-VASc score were used to evaluate 
      the atrial fibrillation-related risk of stroke, and HAS-BLED score was used to 
      estimate the oral anticoagulation-bleeding risk. We investigated the 
      relationships between these 3 scores and the outcomes of acute ischemic stroke 
      (AIS) patients with rheumatic heart disease (RHD) at 3 months after stroke. 
      METHODS: We retrospectively included patients admitted within 1 month after 
      stroke from October 2011 to February 2014 who was also diagnosed with RHD. The 
      patients' demographics; National Institutes of Health Stroke Scale score on 
      admission; risk factors; prior anticoagulation; and CHADS2, CHA2DS2-VASc, and 
      HAS-BLED scores on admission were collected, and symptomatic intracranial 
      hemorrhage (sICH) during hospitalization was observed as well. The patients were 
      followed up at 3 months after stroke to assess the clinical outcomes. RESULTS: Of 
      1425 patients with AIS, 172 patients were diagnosed with RHD. Eleven patients 
      (6.4%) were lost to follow-up at 3 months. One hundred sixty-one patients (48 
      males, mean age 57.5 years) were finally analyzed in the study. The HAS-BLED 
      score was associated with the occurrence of sICH in both univariate (P = .001; 
      odds ratio [OR] 2.223, 95% confidence interval [CI] 1.40-3.54) and multivariate 
      analysis (P = .031; OR 2.366, 95% CI 1.08-5.17). The CHADS2 and CHA2DS2-VASc 
      scores were both related to the sICH (CHADS2: P = .032; OR 1.522, 95% CI 
      1.04-2.23; CHA2DS2-VASc: P = .011; OR 1.498, 95% CI 1.10-2.04, respectively), and 
      to the poor outcomes at 3 months (CHADS2: P = .013; OR .688, 95% CI .51-.92; 
      CHA2DS2-VASc: P = .014; OR .754, 95% CI .60-.94, respectively) in the univariate 
      analysis. CONCLUSION: The HAS-BLED score was independently associated with the 
      occurrence of sICH in AIS patients with RHD.
CI  - Copyright (c) 2016 National Stroke Association. Published by Elsevier Inc. All 
      rights reserved.
FAU - Liu, Junfeng
AU  - Liu J
AD  - Stroke Clinical Research Unit, Department of Neurology, West China Hospital, 
      Sichuan University, Chengdu, China.
FAU - Wang, Deren
AU  - Wang D
AD  - Stroke Clinical Research Unit, Department of Neurology, West China Hospital, 
      Sichuan University, Chengdu, China.
FAU - Tan, Ge
AU  - Tan G
AD  - Stroke Clinical Research Unit, Department of Neurology, West China Hospital, 
      Sichuan University, Chengdu, China.
FAU - Yuan, Ruozhen
AU  - Yuan R
AD  - Stroke Clinical Research Unit, Department of Neurology, West China Hospital, 
      Sichuan University, Chengdu, China.
FAU - Xu, Mangmang
AU  - Xu M
AD  - Stroke Clinical Research Unit, Department of Neurology, West China Hospital, 
      Sichuan University, Chengdu, China.
FAU - Xiong, Yao
AU  - Xiong Y
AD  - Stroke Clinical Research Unit, Department of Neurology, West China Hospital, 
      Sichuan University, Chengdu, China.
FAU - Liu, Ming
AU  - Liu M
AD  - Stroke Clinical Research Unit, Department of Neurology, West China Hospital, 
      Sichuan University, Chengdu, China. Electronic address: wyplmh@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160108
PL  - United States
TA  - J Stroke Cerebrovasc Dis
JT  - Journal of stroke and cerebrovascular diseases : the official journal of National 
      Stroke Association
JID - 9111633
RN  - 0 (Anticoagulants)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anticoagulants/therapeutic use
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - *Outcome Assessment, Health Care
MH  - Predictive Value of Tests
MH  - Retrospective Studies
MH  - Rheumatic Heart Disease/*complications
MH  - *Risk Assessment
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Stroke/*complications/*diagnosis
OTO - NOTNLM
OT  - CHA2DS2-VASc
OT  - CHADS2
OT  - HAS-BLED
OT  - Stroke
OT  - outcomes
OT  - rheumatic heart disease
EDAT- 2016/01/18 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/01/18 06:00
PHST- 2015/08/05 00:00 [received]
PHST- 2015/08/27 00:00 [revised]
PHST- 2015/09/06 00:00 [accepted]
PHST- 2016/01/18 06:00 [entrez]
PHST- 2016/01/18 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - S1052-3057(15)00489-9 [pii]
AID - 10.1016/j.jstrokecerebrovasdis.2015.09.003 [doi]
PST - ppublish
SO  - J Stroke Cerebrovasc Dis. 2016 Mar;25(3):722-6. doi: 
      10.1016/j.jstrokecerebrovasdis.2015.09.003. Epub 2016 Jan 8.