PMID- 26775143
OWN - NLM
STAT- MEDLINE
DCOM- 20171214
LR  - 20190122
IS  - 1556-3871 (Electronic)
IS  - 1547-5271 (Linking)
VI  - 13
IP  - 5
DP  - 2016 May
TI  - The association of baseline left atrial structure and function measured with 
      cardiac magnetic resonance and pulmonary vein isolation outcome in patients with 
      drug-refractory atrial fibrillation.
PG  - 1037-1044
LID - S1547-5271(16)00061-8 [pii]
LID - 10.1016/j.hrthm.2016.01.016 [doi]
AB  - BACKGROUND: Prognostic significance of left atrial (LA) function in patients with 
      atrial fibrillation (AF) is poorly defined. OBJECTIVE: To examine the association 
      of LA function measured with cardiac magnetic resonance (CMR) feature-tracking 
      and AF recurrence following catheter ablation. METHODS: One hundred and 
      twenty-one AF patients (72% paroxysmal, mean age 59 +/- 10 years) were enrolled. 
      Baseline LA function was measured by calculating passive, active, and total 
      emptying fractions (LAEF) and analysis of global longitudinal strain and strain 
      rates. Patients were followed up for recurrence of AF or atrial tachycardia (AT). 
      Hazard ratios for recurrence were calculated using Cox proportional models 
      adjusted for potential clinical confounders, type of AF, left ventricular 
      ejection fraction, AF duration, LA volume, and late gadolinium enhancement (LGE). 
      RESULTS: During a mean follow-up of 18 +/- 9 months, 52 patients (43%) experienced 
      recurrent AF/AT. Patients with recurrent AF/AT had higher baseline LA volume 
      index and lower LA passive, and total LAEF (P < .05 for all). The baseline peak 
      LA strain and strain rates in all phases of LA function were lower in the AF/AT 
      recurrence group (P < .01 for all). In multivariable analysis total LAEF, peak LA 
      strain, and systolic and late diastolic strain rates were associated with 
      recurrence. Both peak LA strain and total LAEF improved prediction of recurrent 
      AT/AF compared to the baseline clinical model, including LA LGE (C statistic 0.82 
      vs 0.77, P < .05 for both total LAEF and peak LA strain). CONCLUSIONS: LA 
      reservoir function was independently associated with recurrent AF/AT after PVI 
      and can additionally improve risk stratification in patients undergoing PVI.
CI  - Copyright (c) 2016 Heart Rhythm Society. Published by Elsevier Inc. All rights 
      reserved.
FAU - Habibi, Mohammadali
AU  - Habibi M
AD  - Department of Cardiology, Baltimore, Maryland. Electronic address: 
      mhabibi3@jhmi.edu.
FAU - Lima, Joao A C
AU  - Lima JAC
AD  - Department of Cardiology, Baltimore, Maryland.
FAU - Gucuk Ipek, Esra
AU  - Gucuk Ipek E
AD  - Department of Cardiology, Baltimore, Maryland.
FAU - Zimmerman, Stefan L
AU  - Zimmerman SL
AD  - Department of Radiology, The Johns Hopkins University School of Medicine, 
      Baltimore, Maryland.
FAU - Zipunnikov, Vadim
AU  - Zipunnikov V
AD  - Department of Biostatistics.
FAU - Spragg, David
AU  - Spragg D
AD  - Department of Cardiology, Baltimore, Maryland.
FAU - Ashikaga, Hiroshi
AU  - Ashikaga H
AD  - Department of Cardiology, Baltimore, Maryland.
FAU - Rickard, John
AU  - Rickard J
AD  - Department of Cardiology, Baltimore, Maryland.
FAU - Marine, Joseph E
AU  - Marine JE
AD  - Department of Cardiology, Baltimore, Maryland.
FAU - Berger, Ronald D
AU  - Berger RD
AD  - Department of Cardiology, Baltimore, Maryland.
FAU - Calkins, Hugh
AU  - Calkins H
AD  - Department of Cardiology, Baltimore, Maryland.
FAU - Nazarian, Saman
AU  - Nazarian S
AD  - Department of Cardiology, Baltimore, Maryland; Department of Epidemiology, The 
      Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
LA  - eng
PT  - Journal Article
DEP - 20160114
PL  - United States
TA  - Heart Rhythm
JT  - Heart rhythm
JID - 101200317
RN  - 0 (Anti-Arrhythmia Agents)
SB  - IM
MH  - Aged
MH  - Anti-Arrhythmia Agents/*therapeutic use
MH  - Atrial Fibrillation/drug therapy/physiopathology/*surgery
MH  - Catheter Ablation/adverse effects/methods
MH  - Drug Resistance
MH  - Female
MH  - *Heart Atria/diagnostic imaging/pathology/physiopathology
MH  - Heart Function Tests/methods
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Maryland
MH  - Middle Aged
MH  - *Postoperative Complications/diagnosis/etiology/prevention & control
MH  - Predictive Value of Tests
MH  - Proportional Hazards Models
MH  - Pulmonary Veins/surgery
MH  - Recurrence
MH  - Risk Assessment/methods
OTO - NOTNLM
OT  - Cardiac MRI
OT  - Left atrial fibrosis
OT  - Left atrial function
OT  - Pulmonary vein isolation
EDAT- 2016/01/18 06:00
MHDA- 2017/12/15 06:00
CRDT- 2016/01/18 06:00
PHST- 2015/05/15 00:00 [received]
PHST- 2016/01/18 06:00 [entrez]
PHST- 2016/01/18 06:00 [pubmed]
PHST- 2017/12/15 06:00 [medline]
AID - S1547-5271(16)00061-8 [pii]
AID - 10.1016/j.hrthm.2016.01.016 [doi]
PST - ppublish
SO  - Heart Rhythm. 2016 May;13(5):1037-1044. doi: 10.1016/j.hrthm.2016.01.016. Epub 
      2016 Jan 14.