PMID- 26775167
OWN - NLM
STAT- MEDLINE
DCOM- 20161011
LR  - 20220311
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 236
DP  - 2016 Feb 28
TI  - Neurological soft signs in euthymic bipolar I patients: A comparative study with 
      healthy siblings and controls.
PG  - 173-178
LID - S0165-1781(15)30755-1 [pii]
LID - 10.1016/j.psychres.2015.11.047 [doi]
AB  - Neurological Soft Signs (NSS) are endophenotypic markers widely studied in 
      schizophrenia and remain poorly evaluated in bipolar disorder. The aims of this 
      paper were to determine the prevalence and scores of NSS in bipolar I patients, 
      compared to healthy siblings and controls and to explore correlations with 
      socio-demographic and clinical features of patients. This was a case-control 
      study comparing 92 euthymic bipolar I patients, 44 of their healthy siblings and 
      60 control subjects. The neurological assessment was performed through the NSS 
      scale validated by Krebs et al. (2000). Bipolar I patients were also assessed 
      with the Bech-Rafaelsen Mania Scale (MAS), the Hamilton Depression Rating Scale 
      (HDRS) and the Global Assessment of Functioning (GAF). The raters were not 
      blinded to groups. The prevalence and the total score of NSS were significantly 
      higher in bipolar I patients compared to their healthy siblings and controls. The 
      sibling group had significantly higher NSS prevalence and total score than 
      controls. No correlation was found between NSS total score and socio-demographic 
      and clinical features of patients, except a negative correlation with the school 
      level and the GAF score. In conclusion, bipolar I patients have motor and sensory 
      signs, which are unrelated to their clinical features.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Mrad, Amel
AU  - Mrad A
AD  - Research Laboratory "Vulnerability to Psychotic Disorders", Department of 
      Psychiatry, Fattouma Bourguiba University Hospital, Monastir, Tunisia. Electronic 
      address: mrad_amel2003@yahoo.fr.
FAU - Wassim Krir, Mohamed
AU  - Wassim Krir M
AD  - Research Laboratory "Vulnerability to Psychotic Disorders", Department of 
      Psychiatry, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
FAU - Ajmi, Ines
AU  - Ajmi I
AD  - Research Laboratory "Vulnerability to Psychotic Disorders", Department of 
      Psychiatry, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
FAU - Gaha, Lotfi
AU  - Gaha L
AD  - Research Laboratory "Vulnerability to Psychotic Disorders", Department of 
      Psychiatry, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
FAU - Mechri, Anwar
AU  - Mechri A
AD  - Research Laboratory "Vulnerability to Psychotic Disorders", Department of 
      Psychiatry, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20151128
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
SB  - IM
MH  - Adult
MH  - Bipolar Disorder/*physiopathology/psychology
MH  - Case-Control Studies
MH  - Female
MH  - Health Status
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nervous System Diseases/*psychology
MH  - Neurologic Examination
MH  - Prevalence
MH  - Psychiatric Status Rating Scales
MH  - *Siblings
MH  - Young Adult
OTO - NOTNLM
OT  - Bipolar I disorder
OT  - Case control study
OT  - Healthy siblings
OT  - Neurodevelopmental hypothesis
OT  - Neurological soft signs
EDAT- 2016/01/18 06:00
MHDA- 2016/10/12 06:00
CRDT- 2016/01/18 06:00
PHST- 2015/01/17 00:00 [received]
PHST- 2015/07/28 00:00 [revised]
PHST- 2015/11/27 00:00 [accepted]
PHST- 2016/01/18 06:00 [entrez]
PHST- 2016/01/18 06:00 [pubmed]
PHST- 2016/10/12 06:00 [medline]
AID - S0165-1781(15)30755-1 [pii]
AID - 10.1016/j.psychres.2015.11.047 [doi]
PST - ppublish
SO  - Psychiatry Res. 2016 Feb 28;236:173-178. doi: 10.1016/j.psychres.2015.11.047. 
      Epub 2015 Nov 28.