PMID- 26777037
OWN - NLM
STAT- MEDLINE
DCOM- 20161031
LR  - 20181113
IS  - 1308-5735 (Electronic)
IS  - 1308-5727 (Print)
VI  - 7
IP  - 4
DP  - 2015 Dec
TI  - Low-Grade Inflammation and Increased Arterial Stiffness in Chinese Youth and 
      Adolescents with Newly-Diagnosed Type 2 Diabetes Mellitus.
PG  - 268-73
LID - 10.4274/jcrpe.2187 [doi]
AB  - OBJECTIVE: To investigate the relationship between low-grade inflammation (LI) 
      and increased arterial stiffness in Chinese youth and adolescents with 
      newly-diagnosed type 2 diabetes mellitus (T2DM). METHODS: Ninety-eight subjects 
      aged 10 to 24 years with newly-diagnosed T2DM were investigated for findings of 
      general inflammation. Anthropometric measurements were taken. Data related to 
      arterial stiffness [brachial artery distensibility (Branch D), augmentation index 
      (AIx), carotid-femoral pulse wave velocity (CF-PWV)] were collected. The subjects 
      were divided into a non-LI group (NLI, n=42) and a LI group (n=56) according to 
      their high-sensitivity C-reactive protein (Hs-CRP) levels. RESULTS: There were no 
      significant differences in age and gender between the LI group and the NLI group. 
      CF-PWV and AIx values of the LI group were higher than those of the NLI group 
      (p<0.01), while Branch D values were lower in the LI group (p<0.01). Branch D, 
      CF-PWV, and AIx values correlated significantly with Hs-CRP overall (r=-0.32, 
      0.34, 0.33, all p<0.01). Multivariate models revealed that in either group (LI or 
      NLI), Hs-CRP, as a continuous variable, was an independent determinant of 
      arterial stiffness parameters even after adjusting for other risk factors. 
      CONCLUSION: Newly-diagnosed T2DM youth and adolescents with LI present a more 
      adverse cardiovascular disease risk profile and stiffer arteries. Hs-CRP levels 
      correlated with arterial stiffness parameters and constituted an independent 
      determinant of arterial stiffness.
FAU - Li, Xin
AU  - Li X
AD  - Wuhan University Faculty of Medicine, Zhongnan Hospital, Clinic of Endocrinology, 
      Wuhan, China Phone: 0086-27-67813107 E-mail: wdy2003win@163.com.
FAU - Deng, You-Ping
AU  - Deng YP
FAU - Yang, Miao
AU  - Yang M
FAU - Wu, Yu-Wen
AU  - Wu YW
FAU - Sun, Su-Xin
AU  - Sun SX
FAU - Sun, Jia-Zhong
AU  - Sun JZ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Turkey
TA  - J Clin Res Pediatr Endocrinol
JT  - Journal of clinical research in pediatric endocrinology
JID - 101519456
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cardiovascular Diseases/*diagnosis/epidemiology
MH  - Child
MH  - China/epidemiology
MH  - Comorbidity
MH  - Diabetes Mellitus, Type 2/*diagnosis/epidemiology
MH  - Female
MH  - Humans
MH  - Inflammation/*blood/epidemiology
MH  - Male
MH  - Vascular Stiffness/*physiology
MH  - Young Adult
PMC - PMC4805228
EDAT- 2016/01/19 06:00
MHDA- 2016/11/01 06:00
PMCR- 2015/12/01
CRDT- 2016/01/19 06:00
PHST- 2016/01/19 06:00 [entrez]
PHST- 2016/01/19 06:00 [pubmed]
PHST- 2016/11/01 06:00 [medline]
PHST- 2015/12/01 00:00 [pmc-release]
AID - 1545 [pii]
AID - 10.4274/jcrpe.2187 [doi]
PST - ppublish
SO  - J Clin Res Pediatr Endocrinol. 2015 Dec;7(4):268-73. doi: 10.4274/jcrpe.2187.