PMID- 26777757
OWN - NLM
STAT- MEDLINE
DCOM- 20171102
LR  - 20191210
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Linking)
VI  - 22
IP  - 10
DP  - 2016 Oct
TI  - Preoperative Determinants of Quality of Life and Functional Capacity Response to 
      Left Ventricular Assist Device Therapy.
PG  - 797-805
LID - S1071-9164(16)00007-5 [pii]
LID - 10.1016/j.cardfail.2016.01.006 [doi]
AB  - BACKGROUND: Left ventricular assist devices (LVADs) improve survival, quality of 
      life (QOL), and functional capacity (FC) among patients with end-stage heart 
      failure. Few data are available regarding characteristics associated with QOL and 
      FC response. METHODS AND RESULTS: Patients enrolled in the Heartmate II clinical 
      trials that were alive with ongoing LVAD support at 6 months were included. QOL 
      response criteria included scoring above the lowest quartile on either the 
      Minnesota Living With Heart Failure Questionnaire or the Kansas City 
      Cardiomyopathy Questionnaire. FC responder criteria included improvement in 
      6-minute walk distance (6MWD) >70 meters from baseline, a 6MWD >220 meters at 6 
      months, or New York Heart Association functional class I or II. Independent 
      variables associated with QOL nonresponse included history of diabetes (odds 
      ratio [OR] 1.82, 95% confidence interval [CI] 1.20-2.78), lower mean pulmonary 
      arterial pressure (OR 0.97, 95% CI 0.95-0.99), or a Heartmate II right 
      ventricular risk score >2 (OR 1.77, 95% CI 1.00-3.12). Variables associated with 
      FC nonresponse included history of COPD (OR 1.92, 95% CI 1.22-3.03) or diabetes 
      (OR 1.52, 95% CI 1.01-2.27). Compared with responders, QOL and FC nonresponders 
      had reduced long-term survival. CONCLUSIONS: Preoperative comorbidities, 
      including diabetes, COPD, and right heart failure, may limit the QOL and FC 
      response to LVAD therapy and should be considered during the shared 
      decision-making process.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Kiernan, Michael S
AU  - Kiernan MS
AD  - Divisions of Cardiology, Tufts Medical Center, Boston, Massachusetts. Electronic 
      address: mkiernan@tuftsmedicalcenter.org.
FAU - Sundareswaran, Kartik S
AU  - Sundareswaran KS
AD  - Thoratec Corporation, Pleasanton, California.
FAU - Pham, Duc Thinh
AU  - Pham DT
AD  - Division of Cardiac Surgery, Northwestern University, Chicago, Illinois.
FAU - Kapur, Navin K
AU  - Kapur NK
AD  - Divisions of Cardiology, Tufts Medical Center, Boston, Massachusetts.
FAU - Pereira, Naveen L
AU  - Pereira NL
AD  - Division of Cardiology, Mayo Clinic, Rochester, Minnesota.
FAU - Strueber, Martin
AU  - Strueber M
AD  - Richard DeVos Heart and Lung Transplant Program, Frederik Meijer Heart and 
      Vascular Institute, Spectrum Health, Grand Rapids, Michigan.
FAU - Farrar, David J
AU  - Farrar DJ
AD  - Thoratec Corporation, Pleasanton, California.
FAU - DeNofrio, David
AU  - DeNofrio D
AD  - Divisions of Cardiology, Tufts Medical Center, Boston, Massachusetts.
FAU - Rogers, Joseph G
AU  - Rogers JG
AD  - Division of Cardiology, Duke University Medical Center, Durham, North Carolina.
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Multicenter Study
DEP - 20160114
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
SB  - IM
MH  - Aged
MH  - *Cause of Death
MH  - Clinical Trials as Topic
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/diagnostic imaging/*mortality/*surgery
MH  - Heart Function Tests
MH  - Heart-Assist Devices
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Preoperative Care/methods
MH  - *Quality of Life
MH  - Risk Assessment
MH  - Severity of Illness Index
MH  - Statistics, Nonparametric
MH  - Stroke Volume/*physiology
MH  - Survival Analysis
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Left ventricular assist device
OT  - exercise tolerance
OT  - functional capacity
OT  - heart failure
OT  - predictors
OT  - quality of life
OT  - survival
EDAT- 2016/01/19 06:00
MHDA- 2017/11/03 06:00
CRDT- 2016/01/19 06:00
PHST- 2015/06/24 00:00 [received]
PHST- 2015/12/07 00:00 [revised]
PHST- 2016/01/07 00:00 [accepted]
PHST- 2016/01/19 06:00 [entrez]
PHST- 2016/01/19 06:00 [pubmed]
PHST- 2017/11/03 06:00 [medline]
AID - S1071-9164(16)00007-5 [pii]
AID - 10.1016/j.cardfail.2016.01.006 [doi]
PST - ppublish
SO  - J Card Fail. 2016 Oct;22(10):797-805. doi: 10.1016/j.cardfail.2016.01.006. Epub 
      2016 Jan 14.