PMID- 26778729
OWN - NLM
STAT- MEDLINE
DCOM- 20180117
LR  - 20180117
IS  - 1440-1827 (Electronic)
IS  - 1320-5463 (Linking)
VI  - 66
IP  - 3
DP  - 2016 Mar
TI  - A case of 37 year long Behcet disease resembling Takayasu arteritis: An autopsy 
      report.
PG  - 164-168
LID - 10.1111/pin.12380 [doi]
AB  - A 19-year-old woman with a history of recurrent aphthous stomatitis and genital 
      ulceration was diagnosed with Behcet disease. She was treated with steroids and 
      immunosuppressive agents for more than 30 years, but multiple complications 
      manifested including ileocecal ulcer, aortic valve regurgitation, renal failure, 
      ischemic enterocolitis, and arteriosclerotic obliterans until her death at the 
      age of 56 from pneumonia. An autopsy examination demonstrated an entirely 
      calcified aorta and major aortic branches. The ascending aorta was dilatated 
      55 mm in diameter and branches were all stenosed. Microscopically, the aortic 
      arch and its branches showed collagenous fibrosis of the outer media and 
      adventitia, whereas coronary and abdominal aortic branches showed conventional 
      atherosclerosis. Although the ante-mortem diagnosis was angio-Behcet disease, its 
      pathophysiology along with her clinical history, morphology of the lead pipe-like 
      aorta, predominant destruction of the outer arteries, and a human leukocyte 
      antigen (HLA) haplotype of B39 were all suggestive of Takayasu arteritis. Thus, 
      this case implies that HLA-B39 may be associated with the pathogenesis of 
      arteritis like Takayasu arteritis, even if the primary disease is Behcet disease.
CI  - (c) 2016 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd.
FAU - Sato, Naoko
AU  - Sato N
AD  - Department of Diagnostic Pathology, Kitakyushu General Hospital, Kitakyushu, 
      Japan.
AD  - Department of Pathology, School of Medicine, University of Occupational and 
      Environmental Health, Kitakyushu, Japan.
FAU - Irie, Koji
AU  - Irie K
AD  - Department of Diagnostic Pathology, Kitakyushu General Hospital, Kitakyushu, 
      Japan.
FAU - Kouzuma, Ryoji
AU  - Kouzuma R
AD  - Department of Cardiology, Kitakyushu General Hospital, Kitakyushu, Japan.
FAU - Inoue, Katsumi
AU  - Inoue K
AD  - Department of Laboratory Medicine, Kokura Memorial Hospital, Kitakyushu, Japan.
FAU - Nakayama, Toshiyuki
AU  - Nakayama T
AD  - Department of Pathology, School of Medicine, University of Occupational and 
      Environmental Health, Kitakyushu, Japan.
LA  - eng
PT  - Case Reports
DEP - 20160118
PL  - Australia
TA  - Pathol Int
JT  - Pathology international
JID - 9431380
RN  - 0 (HLA-B39 Antigen)
SB  - IM
MH  - Aorta/pathology
MH  - Aorta, Thoracic/pathology
MH  - Aortic Valve Insufficiency
MH  - Autopsy
MH  - Behcet Syndrome/complications/*diagnosis/drug therapy/pathology
MH  - Fatal Outcome
MH  - Female
MH  - Fibrosis/etiology/pathology
MH  - HLA-B39 Antigen/*metabolism
MH  - Humans
MH  - Pneumonia/complications
MH  - Takayasu Arteritis/diagnosis/*etiology/pathology
MH  - Vascular Calcification
MH  - Young Adult
OTO - NOTNLM
OT  - Angio-Behcet disease
OT  - HLA-B39
OT  - Takayasu arteritis
EDAT- 2016/01/19 06:00
MHDA- 2018/01/18 06:00
CRDT- 2016/01/19 06:00
PHST- 2015/10/13 00:00 [received]
PHST- 2015/12/16 00:00 [accepted]
PHST- 2016/01/19 06:00 [pubmed]
PHST- 2018/01/18 06:00 [medline]
PHST- 2016/01/19 06:00 [entrez]
AID - 10.1111/pin.12380 [doi]
PST - ppublish
SO  - Pathol Int. 2016 Mar;66(3):164-168. doi: 10.1111/pin.12380. Epub 2016 Jan 18.