PMID- 26778830
OWN - NLM
STAT- MEDLINE
DCOM- 20170418
LR  - 20170418
IS  - 1440-1827 (Electronic)
IS  - 1320-5463 (Linking)
VI  - 66
IP  - 2
DP  - 2016 Feb
TI  - Development of a database system and image viewer to assist in the correlation of 
      histopathologic features and digital image analysis with clinical and molecular 
      genetic information.
PG  - 63-74
LID - 10.1111/pin.12382 [doi]
AB  - Pathologists are required to integrate data from multiple sources when making a 
      diagnosis. Furthermore, whole slide imaging (WSI) and next generation sequencing 
      will escalate data size and complexity. Development of well-designed databases 
      that can allow efficient navigation between multiple data types is necessary for 
      both clinical and research purposes. We developed and evaluated an interactive, 
      web-based database that integrates clinical, histologic, immunohistochemical and 
      genetic information to aid in pathologic diagnosis and interpretation with nine 
      lung adenocarcinoma cases. To minimize sectioning artifacts, representative 
      blocks were serially sectioned using automated tissue sectioning (Kurabo 
      Industries, Osaka Japan) and selected slides were stained by multiple techniques, 
      (hematoxylin and eosin [H&E], immunohistochemistry [IHC] or fluorescence in situ 
      hybridization [FISH]). Slides were digitized by WSI scanners. An interactive 
      relational database was designed based on a list of proposed fields covering a 
      variety of clinical, pathologic and molecular parameters. By focusing on the 
      three main tasks of 1.) efficient management of textual information, 2.) 
      effective viewing of all varieties of stained whole slide images (WSI), and 3.) 
      assistance in evaluating WSI with computer-aided diagnosis, this database 
      prototype shows great promise for multi-modality research and diagnosis.
CI  - (c) 2016 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd.
FAU - Yagi, Yukako
AU  - Yagi Y
AD  - Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, 
      USA.
FAU - Riedlinger, Gregory
AU  - Riedlinger G
AD  - Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, 
      USA.
FAU - Xu, Xun
AU  - Xu X
AD  - Sony Electronics, Inc., San Jose, California, USA.
FAU - Nakamura, Akira
AU  - Nakamura A
AD  - Sony Electronics, Inc., San Jose, California, USA.
FAU - Levy, Bruce
AU  - Levy B
AD  - Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, 
      USA.
FAU - Iafrate, A John
AU  - Iafrate AJ
AD  - Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, 
      USA.
FAU - Mino-Kenudson, Mari
AU  - Mino-Kenudson M
AD  - Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, 
      USA.
FAU - Klepeis, Veronica E
AU  - Klepeis VE
AD  - Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, 
      USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160118
PL  - Australia
TA  - Pathol Int
JT  - Pathology international
JID - 9431380
SB  - IM
MH  - Adenocarcinoma/genetics/*pathology
MH  - Aged
MH  - Aged, 80 and over
MH  - Database Management Systems
MH  - *Databases, Factual
MH  - Female
MH  - High-Throughput Nucleotide Sequencing
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Japan
MH  - Lung Neoplasms/genetics/*pathology
MH  - Male
MH  - Middle Aged
MH  - *Pathology, Clinical
MH  - Retrospective Studies
MH  - Sequence Analysis, DNA
OTO - NOTNLM
OT  - database management system
OT  - genetic information
OT  - histopathology
OT  - image analysis
OT  - lung adenocarcinoma
EDAT- 2016/01/19 06:00
MHDA- 2017/04/19 06:00
CRDT- 2016/01/19 06:00
PHST- 2015/06/24 00:00 [received]
PHST- 2015/12/16 00:00 [accepted]
PHST- 2016/01/19 06:00 [entrez]
PHST- 2016/01/19 06:00 [pubmed]
PHST- 2017/04/19 06:00 [medline]
AID - 10.1111/pin.12382 [doi]
PST - ppublish
SO  - Pathol Int. 2016 Feb;66(2):63-74. doi: 10.1111/pin.12382. Epub 2016 Jan 18.