PMID- 26779853
OWN - NLM
STAT- MEDLINE
DCOM- 20170626
LR  - 20170626
IS  - 1897-4279 (Electronic)
IS  - 0022-9032 (Linking)
VI  - 74
IP  - 7
DP  - 2016
TI  - Prognostic significance of red cell distribution width and other red cell 
      parameters in patients with chronic heart failure during two years of follow-up.
PG  - 657-64
LID - 10.5603/KP.a2016.0004 [doi]
AB  - BACKGROUND: Studies published during the last decade seem to indicate red blood 
      cell parameters as inexpensive, rapidly available, and simple tools for the 
      assessment of prognosis in patients with chronic heart failure (CHF). AIM: To 
      evaluate the prognostic value of red cell parameters determined in a routine 
      blood count in patients with CHF. METHODS: The study group included 165 patients 
      with the New York Heart Association (NYHA) class II-IV CHF hospitalised in the 
      2nd Department of Cardiology in Bydgoszcz. On the first day of hospitalisation, 
      all patients in the study group underwent a complete blood count with an 
      assessment of haemoglobin (Hb) level, mean corpuscular volume (MCV), mean 
      corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC) 
      and red blood cell distribution width (RDW). Follow-up was carried over 24 months 
      by phone calls every 3 months. RESULTS: MCV, MCH and MCHC were not shown to be 
      significant predictors of mortality in CHF patients at 1 and 2 years of 
      follow-up. In univariate analysis at 1-year follow-up, the following variables 
      were significantly associated with the occurrence of the study endpoint: Hb level 
      (p = 0.022; HR = 0.80), RDW (p = 0.004; HR = 1.257), and N-terminal pro-B-type 
      na-triuretic peptide (NT-proBNP) level (p = 0.0001; HR = 1). At 2 years of 
      follow-up, the following variables were significantly associated with the 
      occurrence of the study endpoint: left ventricular ejection fraction (p = 0.018; 
      HR = 0.956), NYHA class (p = 0.007; HR = 0.378), RDW (p = 0.044; HR = 1.175), and 
      NT-proBNP level (p < 0.001; HR = 1). Multivariate analysis for 1-year follow-up 
      showed that RDW and NT-proBNP level were independent significant predictors of 
      mortality, while NT-proBNP level (p = 0.006; HR = 1) and NYHA class (p = 0.024; 
      HR = 0.439) were significant predictors of mortality at 2 years of follow-up. 
      Based on receiver operating characteristic curve analysis, the cut-off RDW was 
      15.00% (AUC = 0.63; 0.523-0.737), at 12 months of follow-up and 14.00% (AUC = 
      0.6; 0.504-0.697), at 24 months of follow-up. The cut-off for Hb level was 13.9 
      g/dL (AUC = 0.662; 0.553-0.77), at 12 months of follow-up and 12.2 g/dL (AUC = 
      0.581; 0.482-0.681), at 24 months of follow-up. CONCLUSIONS: Baseline RDW and Hb 
      level in patients hospitalised with the diagnosis of NYHA class II-IV CHF seem to 
      be important predictors of mortality in this population. Among the red blood cell 
      parameters, only RDW was shown to be an independent prognostic factor at 1 year 
      of follow-up but it appeared to lose its significance during longer-term 
      follow-up.
FAU - Wolowiec, Lukasz
AU  - Wolowiec L
AD  - Student Society for Heart Failure Diagnosis and Management, 2nd Department of 
      Cardiology, Health Sciences Faculty, Nicolaus Copernicus University in Torun, 
      Collegium Medicum, Bydgoszcz, Poland 2nd Department of Cardiology, Health 
      Sciences Faculty, Nicolaus Copernicus University in Torun, Collegium Medicum, 
      Bydgoszcz, Poland. lordtor111@gmail.com.
FAU - Rogowicz, Daniel
AU  - Rogowicz D
FAU - Banach, Joanna
AU  - Banach J
FAU - Buszko, Katarzyna
AU  - Buszko K
FAU - Surowiec, Agnieszka
AU  - Surowiec A
FAU - Blazejewski, Jan
AU  - Blazejewski J
FAU - Bujak, Robert
AU  - Bujak R
FAU - Sinkiewicz, Wladyslaw
AU  - Sinkiewicz W
LA  - eng
PT  - Journal Article
DEP - 20160118
PL  - Poland
TA  - Kardiol Pol
JT  - Kardiologia polska
JID - 0376352
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Aged
MH  - Chronic Disease
MH  - *Erythrocyte Indices
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/blood/*diagnosis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/blood
MH  - Peptide Fragments/blood
MH  - Prognosis
OTO - NOTNLM
OT  - chronic heart failure
OT  - haemoglobin
OT  - red blood cell distribution width
OT  - red blood cell parameters
EDAT- 2016/01/19 06:00
MHDA- 2017/06/27 06:00
CRDT- 2016/01/19 06:00
PHST- 2015/06/18 00:00 [received]
PHST- 2015/12/15 00:00 [accepted]
PHST- 2015/10/19 00:00 [revised]
PHST- 2016/01/19 06:00 [entrez]
PHST- 2016/01/19 06:00 [pubmed]
PHST- 2017/06/27 06:00 [medline]
AID - VM/OJS/KP/9921 [pii]
AID - 10.5603/KP.a2016.0004 [doi]
PST - ppublish
SO  - Kardiol Pol. 2016;74(7):657-64. doi: 10.5603/KP.a2016.0004. Epub 2016 Jan 18.