PMID- 26780459
OWN - NLM
STAT- MEDLINE
DCOM- 20180213
LR  - 20221207
IS  - 1559-1182 (Electronic)
IS  - 0893-7648 (Linking)
VI  - 54
IP  - 2
DP  - 2017 Mar
TI  - Elevated Serum Levels of CXC Chemokine Ligand-12 Are Associated with Unfavorable 
      Functional Outcome and Mortality at 6-Month Follow-up in Chinese Patients with 
      Acute Ischemic Stroke.
PG  - 895-903
LID - 10.1007/s12035-015-9645-9 [doi]
AB  - The aim of this study was to examine whether the circulating CXC chemokine 
      ligand-12 (CXCL12) level can predict a 6-month outcome in Chinese patients with 
      acute ischemic stroke (AIS). In a prospective study, CXCL12 levels were measured 
      on admission in the serum of 304 consecutive patients with AIS. The prognostic 
      value of CXCL12 to predict the functional outcome and mortality within 1 year was 
      compared with the National Institutes of Health Stroke Scale score and with other 
      known outcome predictors. A receiver operating characteristic (ROC) curve was 
      used to evaluate the accuracy of serum CXCL12 in predicting functional outcome 
      and mortality. Patients with an unfavorable outcome and non-survivors had 
      significantly increased CXCL12 levels on admission (P < 0.0001 and P < 0.0001). 
      Multivariate logistic regression analysis adjusted for common risk factors showed 
      that CXCL12 (>/=12.4 ng/mL; third quartile) was an independent predictor of 
      functional outcome (odds ratio [OR] = 8.81; 95 % confidence interval [CI] 
      4.92-24.79) and mortality (OR = 10.15; 95 %CI 2.44-27.98). The area under the 
      receiver operating characteristic curve of CXCL12 was 0.84 (95 % CI 0.76-0.92) 
      for functional outcome and 0.87 (95 % CI 0.80-0.93) for mortality. Circulating 
      CXCL12 serum levels at admission is a useful and complementary biomarker to 
      predict functional outcome and mortality 6 months after acute ischemic stroke.
FAU - Cheng, Xuan
AU  - Cheng X
AD  - Department of Neurology, The First Affiliated Hospital of Zhengzhou University, 
      No. 1 Jianshe East Road, Erqi Area, Zhengzhou, 450000, Henan Province, China.
FAU - Lian, Ya-Jun
AU  - Lian YJ
AD  - Department of Neurology, The First Affiliated Hospital of Zhengzhou University, 
      No. 1 Jianshe East Road, Erqi Area, Zhengzhou, 450000, Henan Province, China. 
      lianyajun369@sina.com.
FAU - Ma, Yun-Qing
AU  - Ma YQ
AD  - Department of Neurology, The First Affiliated Hospital of Zhengzhou University, 
      No. 1 Jianshe East Road, Erqi Area, Zhengzhou, 450000, Henan Province, China.
FAU - Xie, Nan-Chang
AU  - Xie NC
AD  - Department of Neurology, The First Affiliated Hospital of Zhengzhou University, 
      No. 1 Jianshe East Road, Erqi Area, Zhengzhou, 450000, Henan Province, China.
FAU - Wu, Chuan-Jie
AU  - Wu CJ
AD  - Department of Neurology, The First Affiliated Hospital of Zhengzhou University, 
      No. 1 Jianshe East Road, Erqi Area, Zhengzhou, 450000, Henan Province, China.
LA  - eng
PT  - Journal Article
DEP - 20160116
PL  - United States
TA  - Mol Neurobiol
JT  - Molecular neurobiology
JID - 8900963
RN  - 0 (Biomarkers)
RN  - 0 (CXCL12 protein, human)
RN  - 0 (Chemokine CXCL12)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Asian People
MH  - Biomarkers/blood
MH  - Brain Ischemia/*blood/diagnostic imaging/mortality
MH  - Chemokine CXCL12/*blood
MH  - Cohort Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mortality/trends
MH  - Prospective Studies
MH  - Recovery of Function/*physiology
MH  - Stroke/*blood/diagnostic imaging/mortality
MH  - Time Factors
OTO - NOTNLM
OT  - Acute ischemic stroke
OT  - CXC chemokine ligand-12
OT  - Chinese
OT  - Functional outcome
OT  - Mortality
EDAT- 2016/01/19 06:00
MHDA- 2018/02/14 06:00
CRDT- 2016/01/19 06:00
PHST- 2015/08/02 00:00 [received]
PHST- 2015/12/16 00:00 [accepted]
PHST- 2016/01/19 06:00 [pubmed]
PHST- 2018/02/14 06:00 [medline]
PHST- 2016/01/19 06:00 [entrez]
AID - 10.1007/s12035-015-9645-9 [pii]
AID - 10.1007/s12035-015-9645-9 [doi]
PST - ppublish
SO  - Mol Neurobiol. 2017 Mar;54(2):895-903. doi: 10.1007/s12035-015-9645-9. Epub 2016 
      Jan 16.