PMID- 26781272
OWN - NLM
STAT- MEDLINE
DCOM- 20160818
LR  - 20221207
IS  - 1471-2415 (Electronic)
IS  - 1471-2415 (Linking)
VI  - 16
DP  - 2016 Jan 18
TI  - Diabetic macular morphology changes may occur in the early stage of diabetes.
PG  - 12
LID - 10.1186/s12886-016-0186-4 [doi]
LID - 12
AB  - BACKGROUND: The purpose of this study was to observe whether invisible 
      morphological changes are presented in the two types of diabetes mellitus 
      patients without diabetic retinopathy. METHODS: Twenty-six type 1 diabetes 
      mellitus (T1DM) patients and 34 type 2 diabetes mellitus (T2DM) patients without 
      diabetic retinopathy (DR) were recruited for this study. They underwent complete 
      examinations that included stereoscopic color fundus photography and optical 
      coherence tomography (OCT). The OCT patterns were used to measure the macular 
      retinal thickness (RT), the ganglion cell and inner plexiform layer (GC-IPL) 
      complex thickness, the inner nuclear layer (INL) thickness, the outer nuclear 
      layer (ONL) thickness and the subfoveal choroidal thickness (SFCT) using the 
      enhanced depth imaging (EDI) patterns and the retinal fiber layer (RNFL) 
      thickness around the optic disc. All results were compared to those of age- and 
      sex-matched control groups. RESULTS: In the patients with T1DM, the mean RT and 
      GC-IPL complex thicknesses were significantly thinner than those of the control 
      group (p < 0.05). The RNFL was found to be thinner at the 9 o'clock position 
      around the optic disc in the patients compared with the control group. The SFCTs 
      were similar in the controls and subjects. The INL and ONL were decreased in 
      parts of the pericentral and peripheral areas in the T1DM patients (p < 0.05) and 
      increased in the T2DM patients (p < 0.05). CONCLUSIONS: This study demonstrated 
      that in short-duration T1DM patients, the layers of the retina are affected and 
      that the neural tissue has begun to be lost. As diabetes develops, 
      neurodegeneration may cause vascular permeability, which causes thickening of the 
      retinal layers.
FAU - Chen, Yanwei
AU  - Chen Y
AD  - The Department of Ophthalmology, RuiJin Hospital Affiliated Shanghai Jiao Tong 
      University School of Medicine, Shanghai, China.
FAU - Li, Jianfang
AU  - Li J
AD  - The Department of Ophthalmology, RuiJin Hospital Affiliated Shanghai Jiao Tong 
      University School of Medicine, Shanghai, China.
FAU - Yan, Yan
AU  - Yan Y
AD  - The Department of Ophthalmology, RuiJin Hospital Affiliated Shanghai Jiao Tong 
      University School of Medicine, Shanghai, China. hz2004yan@163.com.
FAU - Shen, Xi
AU  - Shen X
AD  - The Department of Ophthalmology, RuiJin Hospital Affiliated Shanghai Jiao Tong 
      University School of Medicine, Shanghai, China. carl_shen2005@126.com.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160118
PL  - England
TA  - BMC Ophthalmol
JT  - BMC ophthalmology
JID - 100967802
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Blood Glucose/metabolism
MH  - Diabetes Mellitus, Type 1/*pathology
MH  - Diabetes Mellitus, Type 2/*pathology
MH  - Diabetic Retinopathy/*pathology
MH  - Early Diagnosis
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/pathology
MH  - Photography
MH  - Retina/*pathology
MH  - Retinal Ganglion Cells/pathology
MH  - Tomography, Optical Coherence
MH  - Young Adult
PMC - PMC4716641
EDAT- 2016/01/20 06:00
MHDA- 2016/08/19 06:00
PMCR- 2016/01/18
CRDT- 2016/01/20 06:00
PHST- 2015/05/07 00:00 [received]
PHST- 2016/01/06 00:00 [accepted]
PHST- 2016/01/20 06:00 [entrez]
PHST- 2016/01/20 06:00 [pubmed]
PHST- 2016/08/19 06:00 [medline]
PHST- 2016/01/18 00:00 [pmc-release]
AID - 10.1186/s12886-016-0186-4 [pii]
AID - 186 [pii]
AID - 10.1186/s12886-016-0186-4 [doi]
PST - epublish
SO  - BMC Ophthalmol. 2016 Jan 18;16:12. doi: 10.1186/s12886-016-0186-4.