PMID- 26781979
OWN - NLM
STAT- MEDLINE
DCOM- 20170214
LR  - 20210103
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 37
IP  - 7
DP  - 2016 Jul
TI  - YKL-40/chitinase-3-like protein 1 is associated with poor prognosis and promotes 
      cell growth and migration of cholangiocarcinoma.
PG  - 9451-63
LID - 10.1007/s13277-016-4838-z [doi]
AB  - YKL-40, a chitinase-like glycoprotein, is expressed at a high level in cancer 
      patients. Its exact function is unknown and is the subject of current 
      investigation. Here, we report the correlation of plasma YKL-40 levels with 
      clinicopathological features of cholangiocarcinoma (CCA), a lethal bile duct 
      cancer, particularly prevalent in Northeastern Thailand. Statistical analysis of 
      plasma YKL-40 concentrations in 57 CCA patients and 41 normal healthy subjects 
      gave a median value of 169.5 ng/mL for CCA patients compared with 46.9 ng/mL for 
      the control subjects (P < 0.0001). There was no significant association of plasma 
      YKL-40 levels with patient age, tumor grade, or histology type. However, 
      Kaplan-Meier analysis suggested that the elevated plasma YKL-40 level was 
      particularly associated with short survival in CCA patients (P = 0.038). 
      Immunohistochemical examination of 34 CCA tissues revealed low expression of 
      YKL-40 in CCA cells, but high expression in adjacent intratumoral stroma, liver, 
      and connective tissues. Univariate analysis showed significant association of the 
      intratumoral YKL-40 expression in CCA tissues with the non-papillary type CCA. 
      Addition of rYKL-40 in the culture medium and transient expression of YKL-40 in 
      CCA cell lines were shown to promote the growth and migration of the tumor cells, 
      and that YKL-40 interacted with a cell-surface receptor involved in the 
      Akt/Erk-mediated pathway. In conclusion, our results support the proposal of 
      YKL-40 as a new candidate prognostic biomarker for cancer diseases.
FAU - Thongsom, Sunisa
AU  - Thongsom S
AD  - Biochemistry-Electrochemistry Research Unit and School of Biochemistry, Suranaree 
      University of Technology, Nakhon Ratchasima, 30000, Thailand.
FAU - Chaocharoen, Wethaka
AU  - Chaocharoen W
AD  - Biochemistry-Electrochemistry Research Unit and School of Biochemistry, Suranaree 
      University of Technology, Nakhon Ratchasima, 30000, Thailand.
FAU - Silsirivanit, Atit
AU  - Silsirivanit A
AD  - Department of Biochemistry, Faculty of Medicine, Liver Fluke and 
      Cholangiocarcinoma Research Center, Khon Kaen University, Khon Kaen, 40002, 
      Thailand.
FAU - Wongkham, Sopit
AU  - Wongkham S
AD  - Department of Biochemistry, Faculty of Medicine, Liver Fluke and 
      Cholangiocarcinoma Research Center, Khon Kaen University, Khon Kaen, 40002, 
      Thailand.
FAU - Sripa, Banchob
AU  - Sripa B
AD  - Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 
      40002, Thailand.
FAU - Choe, Han
AU  - Choe H
AD  - Bio-Medical Institute of Technology and Department of Physiology, University of 
      Ulsan, Seoul, 138-736, South Korea.
FAU - Suginta, Wipa
AU  - Suginta W
AD  - Biochemistry-Electrochemistry Research Unit and School of Biochemistry, Suranaree 
      University of Technology, Nakhon Ratchasima, 30000, Thailand. wipa@sut.ac.th.
AD  - Center of Excellence on Advanced Functional Materials, Suranaree University of 
      Technology, Nakhon Ratchasima, 30000, Thailand. wipa@sut.ac.th.
FAU - Talabnin, Chutima
AU  - Talabnin C
AD  - Biochemistry-Electrochemistry Research Unit and School of Biochemistry, Suranaree 
      University of Technology, Nakhon Ratchasima, 30000, Thailand. 
      chutima.sub@sut.ac.th.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20160119
PL  - Netherlands
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental 
      Biology and Medicine
JID - 8409922
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CHI3L1 protein, human)
RN  - 0 (Chitinase-3-Like Protein 1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Apoptosis
MH  - Bile Duct Neoplasms/metabolism/*pathology
MH  - Bile Ducts, Intrahepatic/metabolism/*pathology
MH  - Biomarkers, Tumor/*metabolism
MH  - Blotting, Western
MH  - Carcinoma, Papillary/metabolism/*pathology
MH  - Case-Control Studies
MH  - Cell Adhesion
MH  - *Cell Movement
MH  - *Cell Proliferation
MH  - Chitinase-3-Like Protein 1/*metabolism
MH  - Cholangiocarcinoma/metabolism/*pathology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Survival Rate
MH  - Tumor Cells, Cultured
OTO - NOTNLM
OT  - Chitinase-3-like protein 1
OT  - Cholangiocarcinoma
OT  - GH-18 glycosyl hydrolases
OT  - Prognostic marker
OT  - YKL-40
EDAT- 2016/01/20 06:00
MHDA- 2017/02/15 06:00
CRDT- 2016/01/20 06:00
PHST- 2015/10/22 00:00 [received]
PHST- 2016/01/11 00:00 [accepted]
PHST- 2016/01/20 06:00 [entrez]
PHST- 2016/01/20 06:00 [pubmed]
PHST- 2017/02/15 06:00 [medline]
AID - 10.1007/s13277-016-4838-z [pii]
AID - 10.1007/s13277-016-4838-z [doi]
PST - ppublish
SO  - Tumour Biol. 2016 Jul;37(7):9451-63. doi: 10.1007/s13277-016-4838-z. Epub 2016 
      Jan 19.