PMID- 26782453
OWN - NLM
STAT- MEDLINE
DCOM- 20161012
LR  - 20220330
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 14
IP  - 4
DP  - 2015 Dec 22
TI  - Sevoflurane induces neurotoxicity in young mice through FAS/FASL signaling.
PG  - 18059-68
LID - 10.4238/2015.December.22.32 [doi]
AB  - Sevoflurane, the most widely used anesthetic in clinical practice, has been shown 
      to induce apoptosis, inhibit neurogenesis, and cause learning and memory 
      impairment in young mice. However, the underlying mechanism is still unknown. In 
      this study, wild-type and the FAS- or FAS ligand (FASL)-knockout mice (age 7 
      days) were exposed to sevoflurane or pure oxygen. Western blotting was used to 
      examine the expression of FAS protein. Terminal deoxynucleotidyl transferase dUTP 
      nick-end labeling (TUNEL) and bromodeoxyuridine (BrdU) staining were employed to 
      quantify the apoptotic cells and newborn cells in the hippocampus and Morris 
      water maze (MWM) in order to evaluate learning and memory status. Sevoflurane 
      significantly increased the expression of FAS protein in wild-type mice. Compared 
      to FAS- and FASL-knockout mice treated with sevoflurane, sevoflurane-treated 
      wild-type mice exhibited more TUNEL-positive hippocampal cells and less 
      BrdU-positive hippocampal cells. The MWM showed that compared with FAS- and 
      FASL-knockout mice treated with sevoflurane, sevoflurane treatment of wild-type 
      mice significantly prolonged the escape latency and reduced platform crossing 
      times. These data suggest that sevoflurane induces neurotoxicity in young mice 
      through FAS-FASL signaling.
FAU - Song, Q
AU  - Song Q
AD  - Department of Anesthesiology, Zhengzhou Central Hospital, Zhengzhou, Henan 
      Province, China.
FAU - Ma, Y L
AU  - Ma YL
AD  - Department of Anesthesiology, Zhengzhou Central Hospital, Zhengzhou, Henan 
      Province, China.
FAU - Song, J Q
AU  - Song JQ
AD  - Department of Anesthesiology, Zhengzhou Central Hospital, Zhengzhou, Henan 
      Province, China.
FAU - Chen, Q
AU  - Chen Q
AD  - Department of Anesthesiology, Zhengzhou Central Hospital, Zhengzhou, Henan 
      Province, China.
FAU - Xia, G S
AU  - Xia GS
AD  - Department of Anesthesiology, Zhengzhou Central Hospital, Zhengzhou, Henan 
      Province, China.
FAU - Ma, J Y
AU  - Ma JY
AD  - Department of Anesthesiology, Zhengzhou Central Hospital, Zhengzhou, Henan 
      Province, China.
FAU - Feng, F
AU  - Feng F
AD  - Department of Anesthesiology, Zhengzhou Central Hospital, Zhengzhou, Henan 
      Province, China.
FAU - Fei, X J
AU  - Fei XJ
AD  - Department of Anesthesia and Critical Care, Massachusetts General Hospital and 
      Harvard Medical School, Charlestown, MA, USA.
AD  - Department of Hospital Infections, Shuguang Hospital Affiliated with Shanghai 
      University of Traditional Chinese Medicine, Shanghai, China.
FAU - Wang, Q M
AU  - Wang QM
AD  - Department of Anesthesiology, Zhengzhou Central Hospital, Zhengzhou, Henan 
      Province, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151222
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (Anesthetics)
RN  - 0 (Fas Ligand Protein)
RN  - 0 (Fasl protein, mouse)
RN  - 0 (Methyl Ethers)
RN  - 0 (fas Receptor)
RN  - 38LVP0K73A (Sevoflurane)
SB  - IM
MH  - Anesthetics/adverse effects
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Fas Ligand Protein/biosynthesis/*genetics
MH  - Humans
MH  - Maze Learning/drug effects
MH  - Methyl Ethers/*adverse effects
MH  - Mice
MH  - Mice, Knockout
MH  - Neurogenesis/drug effects
MH  - Neurotoxicity Syndromes/etiology/*genetics
MH  - Sevoflurane
MH  - fas Receptor/biosynthesis/*genetics
EDAT- 2016/01/20 06:00
MHDA- 2016/10/13 06:00
CRDT- 2016/01/20 06:00
PHST- 2016/01/20 06:00 [entrez]
PHST- 2016/01/20 06:00 [pubmed]
PHST- 2016/10/13 06:00 [medline]
AID - gmr7018 [pii]
AID - 10.4238/2015.December.22.32 [doi]
PST - epublish
SO  - Genet Mol Res. 2015 Dec 22;14(4):18059-68. doi: 10.4238/2015.December.22.32.