PMID- 26784019
OWN - NLM
STAT- MEDLINE
DCOM- 20170110
LR  - 20170111
IS  - 1423-0356 (Electronic)
IS  - 0025-7931 (Linking)
VI  - 91
IP  - 2
DP  - 2016
TI  - The Impact of Obstructive Sleep Apnea and Tobacco Smoking on Endothelial 
      Function.
PG  - 124-31
LID - 10.1159/000443527 [doi]
AB  - BACKGROUND: Endothelial dysfunction has been recognized to occur in the context 
      of obstructive sleep apnea (OSA) or tobacco smoking. However, the deleterious 
      effect on vascular function with concurrence of both conditions is largely 
      unknown. OBJECTIVE: To investigate whether the concurrence of OSA and smoking 
      poses an additive detriment to endothelial dysfunction. METHODS: Chinese men 
      without a history of chronic medical illness were invited to complete a 
      questionnaire including smoking pack-year exposure, polysomnography and 
      peripheral arterial tonometry (PAT) for endothelial function. Serum 
      8-isoprostane, advanced oxidation protein products (AOPP) and monocyte 
      chemo-attractant protein-1 (MCP-1) were measured. RESULTS: 114 men were 
      successfully enrolled. PAT ratio, adjusted for age and body mass index, 
      correlated inversely with overall severity of OSA: apnea-hypopnea index (AHI), r 
      = -0.160 (p = 0.092); oxygen desaturation index, r = -0.214 (p = 0.024); duration 
      of oxygen saturation <90%, r = -0.219 (p = 0.020); and minimum oxygen saturation, 
      r = 0.250 (p = 0.008). The PAT ratio decreased with increasing pack-year group (p 
      = 0.018). It was lower with concurrent smoking history and moderate-severe OSA 
      (AHI >/=15/h) compared to having one or neither factor (p = 0.011). Serum levels of 
      8-isoprostane and AOPP were positively related to severity of OSA, while MCP-1 
      correlated with smoking quantity. Multiple linear regression analyses showed that 
      severity of intermittent hypoxia, MCP-1 and pack-year exposure were independent 
      predictors of PAT ratio. CONCLUSION: While OSA, in particular intermittent 
      hypoxemia, and tobacco smoking were independent risk factors, the concurrence of 
      moderate-severe OSA and smoking was associated with the most severe impairment in 
      endothelial function.
CI  - (c) 2016 S. Karger AG, Basel.
FAU - Lui, Macy Mei Sze
AU  - Lui MM
AD  - Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong 
      Kong, SAR, China.
FAU - Mak, Judith Choi Wo
AU  - Mak JC
FAU - Lai, Agnes Yuen Kwan
AU  - Lai AY
FAU - Hui, Christopher Kim Ming
AU  - Hui CK
FAU - Lam, Jamie Chung Mei
AU  - Lam JC
FAU - Lam, David Chi Leung
AU  - Lam DC
FAU - Ip, Mary Sau Man
AU  - Ip MS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160120
PL  - Switzerland
TA  - Respiration
JT  - Respiration; international review of thoracic diseases
JID - 0137356
RN  - 0 (Advanced Oxidation Protein Products)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 27415-26-5 (8-epi-prostaglandin F2alpha)
RN  - B7IN85G1HY (Dinoprost)
SB  - IM
MH  - Adult
MH  - Advanced Oxidation Protein Products/blood
MH  - Chemokine CCL2/blood
MH  - Cohort Studies
MH  - Dinoprost/analogs & derivatives/blood
MH  - Endothelium, Vascular/*physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Sleep Apnea, Obstructive/blood/*physiopathology
MH  - Smoking/blood/*physiopathology
EDAT- 2016/01/20 06:00
MHDA- 2017/01/11 06:00
CRDT- 2016/01/20 06:00
PHST- 2015/05/04 00:00 [received]
PHST- 2015/12/18 00:00 [accepted]
PHST- 2016/01/20 06:00 [entrez]
PHST- 2016/01/20 06:00 [pubmed]
PHST- 2017/01/11 06:00 [medline]
AID - 000443527 [pii]
AID - 10.1159/000443527 [doi]
PST - ppublish
SO  - Respiration. 2016;91(2):124-31. doi: 10.1159/000443527. Epub 2016 Jan 20.