PMID- 26785247
OWN - NLM
STAT- MEDLINE
DCOM- 20171116
LR  - 20220318
IS  - 1398-9995 (Electronic)
IS  - 0105-4538 (Linking)
VI  - 71
IP  - 5
DP  - 2016 May
TI  - Fish collagen is an important panallergen in the Japanese population.
PG  - 720-3
LID - 10.1111/all.12836 [doi]
AB  - Collagen was identified as a fish allergen in early 2000s. Although its 
      allergenic potential has been suggested to be low, risks associated with collagen 
      as a fish allergen have not been evaluated to a greater extent. In this study, we 
      aimed to clarify the importance of collagen as a fish allergen. Our results 
      showed that 50% of Japanese patients with fish allergy had immunoglobulin E (IgE) 
      against mackerel collagen, whereas 44% had IgE against mackerel parvalbumin. IgE 
      inhibition assay revealed high cross-reactivity of mackerel collagen to 22 fish 
      species (inhibition rates: 87-98%). Furthermore, a recently developed allergy 
      test demonstrated that collagen triggered IgE cross-linking on mast cells. These 
      data indicate that fish collagen is an important and very common panallergen in 
      fish consumed in Japan. The high rate of individuals' collagen allergy may be 
      attributable to the traditional Japanese custom of raw fish consumption.
CI  - (c) 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Kobayashi, Y
AU  - Kobayashi Y
AD  - Department of Marine Biosciences, Tokyo University of Marine Science and 
      Technology, Minato-ku, Tokyo, Japan.
AD  - Course of Safety Management in Food Supply Chain, Tokyo University of Marine 
      Science and Technology, Minato-ku, Tokyo, Japan.
FAU - Akiyama, H
AU  - Akiyama H
AD  - Chemistry Division, Kanagawa Prefectural Institute of Public Health, 
      Chigasaki-shi, Kanagawa, Japan.
FAU - Huge, J
AU  - Huge J
AD  - Course of Safety Management in Food Supply Chain, Tokyo University of Marine 
      Science and Technology, Minato-ku, Tokyo, Japan.
FAU - Kubota, H
AU  - Kubota H
AD  - Course of Safety Management in Food Supply Chain, Tokyo University of Marine 
      Science and Technology, Minato-ku, Tokyo, Japan.
FAU - Chikazawa, S
AU  - Chikazawa S
AD  - Department of Dermatology, National Defense Medical College, Tokorozawa-shi, 
      Saitama, Japan.
FAU - Satoh, T
AU  - Satoh T
AD  - Department of Dermatology, National Defense Medical College, Tokorozawa-shi, 
      Saitama, Japan.
FAU - Miyake, T
AU  - Miyake T
AD  - Department of Dermatology, Shinshu University Hospital, Matsumoto-shi, Nagano, 
      Japan.
FAU - Uhara, H
AU  - Uhara H
AD  - Department of Dermatology, Shinshu University Hospital, Matsumoto-shi, Nagano, 
      Japan.
FAU - Okuyama, R
AU  - Okuyama R
AD  - Department of Dermatology, Shinshu University Hospital, Matsumoto-shi, Nagano, 
      Japan.
FAU - Nakagawara, R
AU  - Nakagawara R
AD  - Department of Dermatology, Yokohama City University School of Medicine, 
      Yokohama-shi, Kanagawa, Japan.
FAU - Aihara, M
AU  - Aihara M
AD  - Department of Dermatology, Yokohama City University School of Medicine, 
      Yokohama-shi, Kanagawa, Japan.
FAU - Hamada-Sato, N
AU  - Hamada-Sato N
AD  - Department of Marine Biosciences, Tokyo University of Marine Science and 
      Technology, Minato-ku, Tokyo, Japan.
AD  - Course of Safety Management in Food Supply Chain, Tokyo University of Marine 
      Science and Technology, Minato-ku, Tokyo, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160208
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Allergens)
RN  - 0 (Epitopes)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Allergens/*immunology
MH  - Animals
MH  - Collagen/*immunology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Epitopes/immunology
MH  - Fishes/*immunology
MH  - Food Hypersensitivity/*epidemiology/*immunology
MH  - Humans
MH  - Immunoglobulin E/immunology
MH  - Japan/epidemiology
MH  - Population Surveillance
OTO - NOTNLM
OT  - collagen
OT  - cross-reactivity
OT  - immunoglobulin E
OT  - mast cell
OT  - parvalbumin
EDAT- 2016/01/20 06:00
MHDA- 2017/11/29 06:00
CRDT- 2016/01/20 06:00
PHST- 2016/01/04 00:00 [accepted]
PHST- 2016/01/20 06:00 [entrez]
PHST- 2016/01/20 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
AID - 10.1111/all.12836 [doi]
PST - ppublish
SO  - Allergy. 2016 May;71(5):720-3. doi: 10.1111/all.12836. Epub 2016 Feb 8.