PMID- 26786235 OWN - NLM STAT- MEDLINE DCOM- 20170206 LR - 20191210 IS - 1472-4146 (Electronic) IS - 0021-9746 (Linking) VI - 69 IP - 8 DP - 2016 Aug TI - The HemoScreen, a novel haematology analyser for the point of care. PG - 720-5 LID - 10.1136/jclinpath-2015-203484 [doi] AB - BACKGROUND AND AIMS: A haematology analyser, based on a new technology, is presented herein. The analyser that provides a complete blood count (CBC) and five-part differential accepts disposable cartridges containing all required reagents, making it maintenance-free and ideal for point-of-care (POC) settings. The test reproducibility and imperviousness to analytical errors are attributed to the imaging-based analysis employed. Imaging enables cell-morphology-based differentiation, which is analogous to the gold standard microscopic analysis. This article presents the HemoScreen new technology and evaluates its performance through a small-scale study conducted in its designated clinical settings. METHODS: Thirty anticoagulated whole blood samples were analysed on the HemoScreen and Sysmex XE-2100. Linear regression was performed for the methods comparison. Two samples with 15 replicates were processed for imprecision. Ease of use of the device was also considered. RESULTS: The HemoScreen demonstrated acceptable imprecision and good agreement with the Sysmex XE-2100. The white blood cells (WBCs), red blood cells (RBCs), haemoglobin (HGB), haematocrit (HCT), platelets (PLT), neutrophils, lymphocytes and eosinophils have coefficients of correlation (r) >0.97. For mean cell volume (MCV), mean cell HGB (MCH) and RBC distribution width (RDW), r values ranged from 0.92 to 0.96. For mean cell HGB concentration (MCHC) and monocytes r=0.82 was demonstrated. User-friendliness and suitability of the device for operation in the designated POC settings was also confirmed. CONCLUSIONS: The HemoScreen employs innovative technologies of viscoelastic focusing and microfluidics within a disposable cartridge for an image-based blood cell analysis. By providing accurate and repeatable CBC and five-part differential results within minutes and maintaining the simplicity of operation, the HemoScreen could have far-reaching implications for use at POC. Further extended evaluation is in progress. CI - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ FAU - Ben-Yosef, Yaara AU - Ben-Yosef Y AD - PixCell Medical Technologies Ltd., Yokneam Ilit, Israel. FAU - Marom, Barak AU - Marom B AD - PixCell Medical Technologies Ltd., Yokneam Ilit, Israel. FAU - Hirshberg, Galit AU - Hirshberg G AD - PixCell Medical Technologies Ltd., Yokneam Ilit, Israel. FAU - D'Souza, Carol AU - D'Souza C AD - Biomedical Sciences, Faculty of Science & Technology, University of Westminster, London, UK. FAU - Larsson, Anders AU - Larsson A AD - Department of Medical Sciences, Uppsala University, Uppsala, Sweden. FAU - Bransky, Avishay AU - Bransky A AD - PixCell Medical Technologies Ltd., Yokneam Ilit, Israel. LA - eng PT - Evaluation Study PT - Journal Article DEP - 20160119 PL - England TA - J Clin Pathol JT - Journal of clinical pathology JID - 0376601 SB - IM MH - Blood Cell Count/*instrumentation MH - Blood Platelets/cytology MH - Erythrocyte Indices MH - Erythrocytes/cytology MH - Hematologic Tests/*instrumentation MH - Hematology/*instrumentation MH - Humans MH - Leukocytes/cytology MH - Monocytes/cytology MH - *Point-of-Care Systems MH - Reproducibility of Results OTO - NOTNLM OT - CELL COUNTING OT - DIAGNOSTICS OT - HAEMATOLOGY OT - IMAGE ANALYSIS OT - POC TESTING EDAT- 2016/01/21 06:00 MHDA- 2017/02/07 06:00 CRDT- 2016/01/21 06:00 PHST- 2015/11/09 00:00 [received] PHST- 2015/12/23 00:00 [accepted] PHST- 2016/01/21 06:00 [entrez] PHST- 2016/01/21 06:00 [pubmed] PHST- 2017/02/07 06:00 [medline] AID - jclinpath-2015-203484 [pii] AID - 10.1136/jclinpath-2015-203484 [doi] PST - ppublish SO - J Clin Pathol. 2016 Aug;69(8):720-5. doi: 10.1136/jclinpath-2015-203484. Epub 2016 Jan 19.