PMID- 26786480
OWN - NLM
STAT- MEDLINE
DCOM- 20161005
LR  - 20181113
IS  - 1471-2407 (Electronic)
IS  - 1471-2407 (Linking)
VI  - 16
DP  - 2016 Jan 19
TI  - Correlation analyses between pre- and post-operative adverse events in gastric 
      cancer patients receiving preoperative treatment and gastrectomy.
PG  - 29
LID - 10.1186/s12885-016-2066-y [doi]
LID - 29
AB  - BACKGROUNDS: Preoperative chemotherapy (PCT) and chemoradiotherapy (PCRT) showed 
      promising results for gastric cancers. However, the influence of preoperative 
      adverse events (AEs) on postoperative complications remains unknown. The aim of 
      this study was to identify correlations between them. METHODS: Clinical data and 
      laboratory findings were retrieved retrospectively for 115 patients who underwent 
      gastrectomy after PCT or PCRT between 2010 and 2013. Preoperative AEs and 
      postoperative complications were classified according to the Common Terminology 
      Criteria for Adverse Events (CTCAE) and Clavien-Dindo (CD) grading systems, 
      respectively. Correlations between CTCAE grades and CD grades were analyzed, and 
      clinical data and laboratory findings were compared among three groups classified 
      according to CD grades: CD0, CD1/2, and CD3/4. RESULTS: There were 61 (53.0%) 
      patients in the CD0 group, 44 (38.3%) patients in the CD1/2 group, and 10 (8.7%) 
      patients in the CD3/4 group. The CTCAE grades did not correlate with the CD 
      grades. Only estimated blood loss (P = 0.019) and transfusion rate (P < 0.001) 
      differed among the three CD groups. CONCLUSION: There are no correlations between 
      pre- and post-operative adverse events in the terms of severity grades in 
      patients with advanced or metastatic gastric cancer who underwent gastrectomy 
      after PCT or PCRT. Meticulous intraoperative manipulations should be emphasized.
FAU - Li, Shuang-Xi
AU  - Li SX
AD  - Department of Surgery, Yonsei University Health System, Yonsei University College 
      of Medicine, 50 Yonsei-ro, Seodaemun-gu, 120-752, Seoul, South Korea. 
      lishuangxi@outlook.com.
AD  - Key laboratory of Carcinogenesis and Translational Research (Ministry of 
      Education), Department of Gastrointestinal Surgery, Peking University Cancer 
      Hospital & Institute, Beijing, China. lishuangxi@outlook.com.
FAU - Seo, Sang Hyuk
AU  - Seo SH
AD  - Department of Surgery, Yonsei University Health System, Yonsei University College 
      of Medicine, 50 Yonsei-ro, Seodaemun-gu, 120-752, Seoul, South Korea. 
      prodegy-seo@hanmail.net.
AD  - Department of Surgery, Inje University Busan Paik Hospital, Inje University 
      College of Medicine, Busan, South Korea. prodegy-seo@hanmail.net.
FAU - Choi, Yoon Young
AU  - Choi YY
AD  - Department of Surgery, Yonsei University Health System, Yonsei University College 
      of Medicine, 50 Yonsei-ro, Seodaemun-gu, 120-752, Seoul, South Korea. 
      LAKI98@yuhs.ac.
FAU - Nakagawa, Masatoshi
AU  - Nakagawa M
AD  - Department of Surgery, Yonsei University Health System, Yonsei University College 
      of Medicine, 50 Yonsei-ro, Seodaemun-gu, 120-752, Seoul, South Korea. 
      mnaksrg2@yahoo.co.jp.
AD  - Department of Gastric Surgery, Tokyo Medical and Dental University, Tokyo, Japan. 
      mnaksrg2@yahoo.co.jp.
FAU - An, Ji Yeong
AU  - An JY
AD  - Department of Surgery, Yonsei University Health System, Yonsei University College 
      of Medicine, 50 Yonsei-ro, Seodaemun-gu, 120-752, Seoul, South Korea. 
      jar319@naver.com.
AD  - Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of 
      Medicine, Seoul, South Korea. jar319@naver.com.
FAU - Kim, Hyoung-Il
AU  - Kim HI
AD  - Department of Surgery, Yonsei University Health System, Yonsei University College 
      of Medicine, 50 Yonsei-ro, Seodaemun-gu, 120-752, Seoul, South Korea. 
      CAIRUS@yuhs.ac.
FAU - Cheong, Jae-Ho
AU  - Cheong JH
AD  - Department of Surgery, Yonsei University Health System, Yonsei University College 
      of Medicine, 50 Yonsei-ro, Seodaemun-gu, 120-752, Seoul, South Korea. 
      jhcheong@yuhs.ac.
FAU - Hyung, Woo Jin
AU  - Hyung WJ
AD  - Department of Surgery, Yonsei University Health System, Yonsei University College 
      of Medicine, 50 Yonsei-ro, Seodaemun-gu, 120-752, Seoul, South Korea. 
      wjhyung@yuhs.ac.
FAU - Noh, Sung Hoon
AU  - Noh SH
AD  - Department of Surgery, Yonsei University Health System, Yonsei University College 
      of Medicine, 50 Yonsei-ro, Seodaemun-gu, 120-752, Seoul, South Korea. 
      sunghoonn@yuhs.ac.
LA  - eng
PT  - Journal Article
DEP - 20160119
PL  - England
TA  - BMC Cancer
JT  - BMC cancer
JID - 100967800
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chemoradiotherapy/*adverse effects
MH  - Female
MH  - Gastrectomy/adverse effects
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Postoperative Complications/chemically induced/*pathology
MH  - Preoperative Care
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Stomach Neoplasms/*drug therapy/pathology/*radiotherapy/surgery
PMC - PMC4717569
EDAT- 2016/01/21 06:00
MHDA- 2016/10/07 06:00
PMCR- 2016/01/19
CRDT- 2016/01/21 06:00
PHST- 2015/10/03 00:00 [received]
PHST- 2016/01/11 00:00 [accepted]
PHST- 2016/01/21 06:00 [entrez]
PHST- 2016/01/21 06:00 [pubmed]
PHST- 2016/10/07 06:00 [medline]
PHST- 2016/01/19 00:00 [pmc-release]
AID - 10.1186/s12885-016-2066-y [pii]
AID - 2066 [pii]
AID - 10.1186/s12885-016-2066-y [doi]
PST - epublish
SO  - BMC Cancer. 2016 Jan 19;16:29. doi: 10.1186/s12885-016-2066-y.