PMID- 26786607
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20230915
IS  - 1806-9460 (Electronic)
IS  - 1516-3180 (Print)
IS  - 1516-3180 (Linking)
VI  - 134
IP  - 1
DP  - 2016 Jan-Feb
TI  - Influence of type 2 diabetes mellitus on liver histology among morbidly obese 
      individuals. A cross-sectional study.
PG  - 79-83
LID - S1516-31802016005001108 [pii]
LID - 10.1590/1516-3180.2015.01652409 [doi]
AB  - CONTEXT AND OBJECTIVE: Nonalcoholic fatty liver disease (NAFLD) has become a 
      public health concern. It encompasses a wide spectrum of histological 
      abnormalities and has close relationships with insulin resistance and type 2 
      diabetes mellitus (T2DM). This study sought to compare the histological 
      alterations observed in morbidly obese individuals with and without T2DM who 
      underwent Roux-en-Y gastric bypass. DESIGN AND SETTING: Cross-sectional study in 
      a tertiary-level public hospital. METHODS: This was a cross-sectional study on 
      197 individuals who underwent gastric bypass surgery between 2011 and 2013. NAFLD 
      was assessed through liver biopsies. T2DM was diagnosed through the International 
      Diabetes Federation criteria. RESULTS: Non-diabetics presented significantly more 
      biopsies without any histological abnormalities, regarding steatosis (42.6% 
      versus 25.5%; P = 0.0400), fibrosis (60.6% versus 36.2%; P = 0.0042) and 
      steatohepatitis (27.3% versus 12.8%; P = 0.0495), while diabetics presented 
      significantly higher frequency of moderate forms of steatosis (36.2% versus 20%; 
      P = 0.0307) and fibrosis (23.4% versus 4%; P = 0.0002). DISCUSSION: T2DM was 
      associated with more advanced forms of NAFLD within the population studied. NAFLD 
      has previously been correlated with severe forms of heart disease. CONCLUSION: 
      Screening for and early detecting of NAFLD in high-risk populations are important 
      for avoiding further development of severe forms and the need for liver 
      transplantation.
FAU - Cazzo, Everton
AU  - Cazzo E
AD  - Department of Surgery, Universidade Estadual de Campinas, Campinas, Sao Paulo, 
      Brazil.
FAU - Jimenez, Laisa Simakawa
AU  - Jimenez LS
AD  - Department of Surgery, Universidade Estadual de Campinas, Campinas, Sao Paulo, 
      Brazil.
FAU - Gallo, Fabio de Felice
AU  - Gallo Fde F
AD  - Department of Surgery, Universidade Estadual de Campinas, Campinas, Sao Paulo, 
      Brazil.
FAU - Pareja, Jose Carlos
AU  - Pareja JC
AD  - Department of Surgery, Universidade Estadual de Campinas, Campinas, Sao Paulo, 
      Brazil.
FAU - Chaim, Elinton Adami
AU  - Chaim EA
AD  - Department of Surgery, Universidade Estadual de Campinas, Campinas, Sao Paulo, 
      Brazil.
LA  - eng
PT  - Journal Article
DEP - 20160119
PL  - Brazil
TA  - Sao Paulo Med J
JT  - Sao Paulo medical journal = Revista paulista de medicina
JID - 100897261
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biopsy
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/complications/*pathology
MH  - Fatty Liver/pathology
MH  - Female
MH  - Fibrosis
MH  - Gastric Bypass/adverse effects
MH  - Humans
MH  - Liver/*pathology
MH  - Male
MH  - Middle Aged
MH  - Non-alcoholic Fatty Liver Disease/complications/etiology/*pathology
MH  - Obesity, Morbid/*surgery
MH  - Young Adult
PMC - PMC10496580
COIS- Conflict of interests: None
EDAT- 2016/01/21 06:00
MHDA- 2016/12/15 06:00
PMCR- 2016/01/19
CRDT- 2016/01/21 06:00
PHST- 2015/09/03 00:00 [received]
PHST- 2015/09/04 00:00 [accepted]
PHST- 2016/01/21 06:00 [entrez]
PHST- 2016/01/21 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
PHST- 2016/01/19 00:00 [pmc-release]
AID - S1516-31802016005001108 [pii]
AID - 10.1590/1516-3180.2015.01652409 [doi]
PST - ppublish
SO  - Sao Paulo Med J. 2016 Jan-Feb;134(1):79-83. doi: 10.1590/1516-3180.2015.01652409. 
      Epub 2016 Jan 19.