PMID- 26787110
OWN - NLM
STAT- MEDLINE
DCOM- 20180328
LR  - 20221207
IS  - 1751-1097 (Electronic)
IS  - 0031-8655 (Linking)
VI  - 92
IP  - 2
DP  - 2016 Mar
TI  - Actinic Prurigo in Singaporean Chinese: A Positive Association with 
      HLA-DRB1*03:01.
PG  - 355-359
LID - 10.1111/php.12569 [doi]
AB  - Studies have reported the association of human leukocyte antigen (HLA) genes with 
      susceptibility to develop actinic prurigo (AP) in Caucasians, but there were no 
      studies in Asian populations, including the Chinese. Our study was performed to 
      determine if AP is associated with susceptibility or protective HLA alleles or 
      haplotypes in Singaporean Chinese. All Chinese patients diagnosed with AP at 
      National Skin Center, Singapore, from January 2002 to April 2015 were invited to 
      participate in the study. Clinical data and phototesting results were collated, 
      and HLA typing was performed. Among 14 patients included, 11 were male and the 
      mean age was 49.6 (37.9-61.3) years. All patients did not have a family history 
      of AP and none had mucosal involvement, as such these clinical features differed 
      from Caucasian AP patients. The frequency of DRB1*03:01 in AP patients was 
      significantly higher compared to healthy controls (43% vs 16%, P = 0.022, odds 
      ratio (OR) 3.89). Concurrently, the frequency of HLA-B*58:01-DRB1*03:01 haplotype 
      was also significantly increased (25% vs 7%, P = 0.004, OR 4.23). In conclusion, 
      HLA-DRB1*03:01 was associated with AP in Singaporean Chinese patients. This novel 
      allelic association may possibly be utilized as a biological marker to aid in the 
      diagnosis of AP in Chinese patients.
CI  - (c) 2016 The American Society of Photobiology.
FAU - Chen, Qiping
AU  - Chen Q
AD  - National Skin Center, Singapore, Singapore.
FAU - Shen, Meixin
AU  - Shen M
AD  - Singapore Immunology Network, A*STAR, Singapore, Singapore.
FAU - Heng, Yee Kiat
AU  - Heng YK
AD  - National Skin Center, Singapore, Singapore.
FAU - Theng, Thiam Seng Colin
AU  - Theng TSC
AD  - National Skin Center, Singapore, Singapore.
FAU - Tey, Hong Liang
AU  - Tey HL
AD  - National Skin Center, Singapore, Singapore.
FAU - Ren, Ee Chee
AU  - Ren EC
AD  - Singapore Immunology Network, A*STAR, Singapore, Singapore.
FAU - Chong, Wei-Sheng
AU  - Chong WS
AD  - National Skin Center, Singapore, Singapore.
LA  - eng
PT  - Journal Article
DEP - 20160211
PL  - United States
TA  - Photochem Photobiol
JT  - Photochemistry and photobiology
JID - 0376425
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*03:01 antigen)
RN  - Actinic Prurigo
SB  - IM
MH  - Adult
MH  - *Asian People
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Photosensitivity Disorders/*epidemiology/ethnology/*genetics
MH  - Singapore/epidemiology/ethnology
MH  - Skin Diseases, Genetic/*epidemiology/ethnology/*genetics
EDAT- 2016/01/21 06:00
MHDA- 2018/03/29 06:00
CRDT- 2016/01/21 06:00
PHST- 2015/11/14 00:00 [received]
PHST- 2015/12/21 00:00 [accepted]
PHST- 2016/01/21 06:00 [pubmed]
PHST- 2018/03/29 06:00 [medline]
PHST- 2016/01/21 06:00 [entrez]
AID - 10.1111/php.12569 [doi]
PST - ppublish
SO  - Photochem Photobiol. 2016 Mar;92(2):355-359. doi: 10.1111/php.12569. Epub 2016 
      Feb 11.