PMID- 26788106
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160120
LR  - 20201001
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2015
DP  - 2015
TI  - Medicinal Plants Qua Glucagon-Like Peptide-1 Secretagogue via Intestinal Nutrient 
      Sensors.
PG  - 171742
LID - 10.1155/2015/171742 [doi]
LID - 171742
AB  - Glucagon-like peptide-1 (GLP-1) participates in glucose homeostasis and feeding 
      behavior. Because GLP-1 is rapidly inactivated by the enzymatic cleavage of 
      dipeptidyl peptidase-4 (DPP4) long-acting GLP-1 analogues, for example, exenatide 
      and DPP4 inhibitors, for example, liraglutide, have been developed as 
      therapeutics for type 2 diabetes mellitus (T2DM). However, the inefficient 
      clinical performance and the incidence of side effects reported on the existing 
      therapeutics for T2DM have led to the development of a novel therapeutic strategy 
      to stimulate endogenous GLP-1 secretion from enteroendocrine L cells. Since the 
      GLP-1 secretion of enteroendocrine L cells depends on the luminal nutrient 
      constituents, the intestinal nutrient sensors involved in GLP-1 secretion have 
      been investigated. In particular, nutrient sensors for tastants, cannabinoids, 
      and bile acids are able to recognize the nonnutritional chemical compounds, which 
      are abundant in medicinal plants. These GLP-1 secretagogues derived from 
      medicinal plants are easy to find in our surroundings, and their effectiveness 
      has been demonstrated through traditional remedies. The finding of GLP-1 
      secretagogues is directly linked to understanding of the role of intestinal 
      nutrient sensors and their recognizable nutrients. Concurrently, this study 
      demonstrates the possibility of developing novel therapeutics for metabolic 
      disorders such as T2DM and obesity using nutrients that are readily accessible in 
      our surroundings.
FAU - Kim, Ki-Suk
AU  - Kim KS
AD  - College of Korean Medicine, Institute of Korean Medicine, Kyung Hee University, 1 
      Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea.
FAU - Jang, Hyeung-Jin
AU  - Jang HJ
AD  - College of Korean Medicine, Institute of Korean Medicine, Kyung Hee University, 1 
      Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20151215
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC4693015
EDAT- 2016/01/21 06:00
MHDA- 2016/01/21 06:01
PMCR- 2015/12/15
CRDT- 2016/01/21 06:00
PHST- 2015/08/25 00:00 [received]
PHST- 2015/11/24 00:00 [accepted]
PHST- 2016/01/21 06:00 [entrez]
PHST- 2016/01/21 06:00 [pubmed]
PHST- 2016/01/21 06:01 [medline]
PHST- 2015/12/15 00:00 [pmc-release]
AID - 10.1155/2015/171742 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2015;2015:171742. doi: 10.1155/2015/171742. 
      Epub 2015 Dec 15.