PMID- 26788508
OWN - NLM
STAT- MEDLINE
DCOM- 20161012
LR  - 20181113
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2015
DP  - 2015
TI  - The Role of FGFR1 Gene Amplification as a Poor Prognostic Factor in Squamous Cell 
      Lung Cancer: A Meta-Analysis of Published Data.
PG  - 763080
LID - 10.1155/2015/763080 [doi]
LID - 763080
AB  - OBJECTIVES: The prognostic factors of the fibroblast growth factor receptor 1 
      (FGFR1) in non-small cell lung cancer (NSCLC) remain controversial. METHODS: We 
      conducted a meta-analysis of published studies from 1974 to February 2015. In 
      absence of quality difference between studies of reporting significant and 
      nonsignificant results, the relationship between FGFR1 amplification and 
      clinicopathological parameters in NSCLC was analyzed. And also the combined 
      hazard ratio (HR) and their corresponding 95% confidence interval (CI) were 
      calculated in terms of overall survival. RESULTS: 3178 patients (12 studies) were 
      included in the analysis. It was shown that FGFR1 amplification was significantly 
      more prevalent among male patients (RR 2.03, 95% CI 1.57-2.63) with squamous cell 
      lung cancer (SQCC) (RR 3.49, 95% CI 2.62-4.64) and current smokers (RR 2.63, 95% 
      CI 1.92-3.60). The pooled data also showed that the FGFR1 amplification was a 
      poor prognostic factor in SQCC (HR 1.38, 95% CI 1.07-1.78), Asian patients (HR 
      1.78, 95% CI 1.22-2.60), and fluorescence in situ hybridization (FISH) method (HR 
      1.30, 95% CI 1.06-1.58). CONCLUSIONS: This meta-analysis strongly suggests that 
      FGFR1 amplification occurs more frequently in male, SQCC and smokers, and it is a 
      risk factor for poor prognosis among Asian patients with SQCC.
FAU - Wang, Yang
AU  - Wang Y
AD  - Division of Oncology, Nanjing Medical University, Nanjing 210000, China.
FAU - Gao, Wen
AU  - Gao W
AD  - Department of Oncology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing 210000, China.
FAU - Xu, Jiali
AU  - Xu J
AD  - Department of Oncology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing 210000, China.
FAU - Chen, Xiaojun
AU  - Chen X
AD  - College of Sciences, Nanjing University of Technology, Nanjing 210000, China.
FAU - Yang, Yang
AU  - Yang Y
AD  - School of Public Health, Division of Biostatistics, The University of Texas 
      Health Science Center at Houston, Houston, TX 77030, USA.
FAU - Zhu, Yizhi
AU  - Zhu Y
AD  - Division of Oncology, Nanjing Medical University, Nanjing 210000, China.
FAU - Yin, Yongmei
AU  - Yin Y
AD  - Department of Oncology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing 210000, China.
FAU - Guo, Renhua
AU  - Guo R
AD  - Department of Oncology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing 210000, China.
FAU - Liu, Ping
AU  - Liu P
AD  - Department of Oncology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing 210000, China.
FAU - Shu, Yongqian
AU  - Shu Y
AD  - Department of Oncology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing 210000, China.
FAU - Liu, Lingxiang
AU  - Liu L
AD  - Department of Oncology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing 210000, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20151216
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - EC 2.7.10.1 (FGFR1 protein, human)
RN  - EC 2.7.10.1 (Receptor, Fibroblast Growth Factor, Type 1)
SB  - IM
MH  - Carcinoma, Non-Small-Cell Lung/*genetics/pathology
MH  - *Gene Amplification
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Neoplasms, Squamous Cell/*genetics/pathology
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Receptor, Fibroblast Growth Factor, Type 1/*genetics
MH  - Smoking/adverse effects
PMC - PMC4695660
EDAT- 2016/01/21 06:00
MHDA- 2016/10/13 06:00
PMCR- 2015/12/16
CRDT- 2016/01/21 06:00
PHST- 2015/08/08 00:00 [received]
PHST- 2015/09/30 00:00 [accepted]
PHST- 2016/01/21 06:00 [entrez]
PHST- 2016/01/21 06:00 [pubmed]
PHST- 2016/10/13 06:00 [medline]
PHST- 2015/12/16 00:00 [pmc-release]
AID - 10.1155/2015/763080 [doi]
PST - ppublish
SO  - Biomed Res Int. 2015;2015:763080. doi: 10.1155/2015/763080. Epub 2015 Dec 16.