PMID- 26790279
OWN - NLM
STAT- MEDLINE
DCOM- 20160310
LR  - 20211203
IS  - 1001-5302 (Print)
IS  - 1001-5302 (Linking)
VI  - 40
IP  - 16
DP  - 2015 Aug
TI  - [Regulative mechanisms of mammalian target of rapamycin signaling pathway in 
      glomerular hypertrophy in diabetic nephropathy and interventional effects of 
      Chinese herbal medicine].
PG  - 3125-31
AB  - Glomerular hypertrophy is the main pathological characteristic in the early stage 
      of diabetic nephropathy (DN), and its regulatory mechanism is closely related to 
      mammalian target of rapamycin (mTOR) signaling pathway activity. mTOR includes 
      mTOR complex 1 (mTORC1) and mTOR complex 2(mTORC2), in which, the upstream 
      pathway of mTORC1 is phosphatidylinositol-3-kinase (PI3K)/serine-threonine 
      kinase(Akt)/adenosine monophosphate activated protein kinase(AMPK), and the 
      representative signaling molecules in the downstream pathway of mTORC1 are 
      4E-binding proteins(4EBP) and phosphoprotein 70 S6Kinase(p70S6K). Some Chinese 
      herbal extracts could improve cell proliferation via intervening the expressions 
      of the key molecules in the upstream or downstream of PIK/Akt/mTOR signaling 
      pathway in vivo. As for glomerular mesangial cells(MC) and podocyte, mTOR plays 
      an important role in regulating glomerular inherent cells, including adjusting 
      cell cycle, energy metabolism and matrix protein synthesis. Rapamycin, the 
      inhibitor of mTOR, could suppress glomerular inherent cell hypertrophy, cell 
      proliferation, glomerular basement membrane (GBM) thickening and mesangial matrix 
      deposition in model rats with DN. Some Chinese herbal extracts could alleviate 
      glomerular lesions by intervening mTOR signaling pathway activity in renal tissue 
      of DN animal models or in renal inherent cells in vivo and in vitro.
FAU - Yang, Jing-Jing
AU  - Yang JJ
FAU - Huang, Yan-ru
AU  - Huang YR
FAU - Wan, Yi-gang
AU  - Wan YG
FAU - Shen, Shan-mei
AU  - Shen SM
FAU - Mao, Zhi-min
AU  - Mao ZM
FAU - Wu, Wei
AU  - Wu W
FAU - Yao, Jian
AU  - Yao J
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - China
TA  - Zhongguo Zhong Yao Za Zhi
JT  - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese 
      materia medica
JID - 8913656
RN  - 0 (Drugs, Chinese Herbal)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Diabetic Nephropathies/*drug therapy/*enzymology/genetics/pathology
MH  - Drugs, Chinese Herbal/*administration & dosage
MH  - Humans
MH  - Hypertrophy/drug therapy/enzymology/genetics/pathology
MH  - Kidney Glomerulus/drug effects/metabolism/pathology
MH  - Signal Transduction/drug effects
MH  - TOR Serine-Threonine Kinases/genetics/*metabolism
EDAT- 2016/01/23 06:00
MHDA- 2016/03/11 06:00
CRDT- 2016/01/22 06:00
PHST- 2016/01/22 06:00 [entrez]
PHST- 2016/01/23 06:00 [pubmed]
PHST- 2016/03/11 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhong Yao Za Zhi. 2015 Aug;40(16):3125-31.