PMID- 26790936
OWN - NLM
STAT- MEDLINE
DCOM- 20161014
LR  - 20161230
IS  - 1873-2542 (Electronic)
IS  - 0378-1135 (Linking)
VI  - 183
DP  - 2016 Feb 1
TI  - Investigation on host susceptibility of Tibetan pig to infection of porcine 
      reproductive and respiratory syndrome virus through viral challenge study.
PG  - 62-8
LID - S0378-1135(15)30105-X [pii]
LID - 10.1016/j.vetmic.2015.11.035 [doi]
AB  - Previous reports showed that infection of porcine reproductive and respiratory 
      syndrome virus (PRRSV) stimulated a variable host response and pig susceptibility 
      to PRRSV was largely dependent on its genetic composition. In the present study, 
      host susceptibility of Tibetan pig to PRRSV was compared with other two pig 
      breeds, ZangMei black and Large White, by challenge of them with highly 
      pathogenic PRRSV (HP-PRRSV). In the first challenge test, each eight piglets of 
      the three breeds were inoculated with HP-PRRSV and clinical symptoms, viremia and 
      animal mortality were examined up to 28 days post inoculation (DPI). In the 
      secondary pathological study, each twelve piglets of the three breeds were 
      challenged and three pigs of each breed were sacrificed on 4, 7, and 14 DPI for 
      examination of gross damage and lung microscopic lesions. The results showed that 
      no typical clinical signs such as cough, diarrhea and high fever were observed in 
      challenged Tibetan pigs, which however all occurred in Large White accompanied 
      with  approximately 40% mortality (3/8). In addition, a significant low and short viremia was 
      detected specifically in Tibetan pigs. Based on histopathological analysis of 
      lung sections, a mild to moderate interstitial pneumonia in Tibetan pigs and a 
      much severe pneumonia in Large White were identified on 7-14 DPI. In summary, the 
      study demonstrated that three genetically different pig breeds exhibited a 
      differential host susceptibility to HP-PRRSV and Tibetan pig was much less 
      susceptible to the virus in the three tested pig breeds.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Kang, Runmin
AU  - Kang R
AD  - College of Life Sciences, Animal Disease Prevention and Food Safety Key 
      Laboratory of Sichuan Province, Key Laboratory of Bio-resources and 
      Eco-environment of Ministry of Education, Sichuan University, Chengdu, PR China; 
      Sichuan Animal Science Academy, Chengdu, PR China.
FAU - Ji, Gaosheng
AU  - Ji G
AD  - College of Life Sciences, Animal Disease Prevention and Food Safety Key 
      Laboratory of Sichuan Province, Key Laboratory of Bio-resources and 
      Eco-environment of Ministry of Education, Sichuan University, Chengdu, PR China.
FAU - Yang, Xin
AU  - Yang X
AD  - College of Life Sciences, Animal Disease Prevention and Food Safety Key 
      Laboratory of Sichuan Province, Key Laboratory of Bio-resources and 
      Eco-environment of Ministry of Education, Sichuan University, Chengdu, PR China.
FAU - Lv, Xuebing
AU  - Lv X
AD  - Sichuan Animal Science Academy, Chengdu, PR China.
FAU - Zhang, Yi
AU  - Zhang Y
AD  - College of Life Sciences, Animal Disease Prevention and Food Safety Key 
      Laboratory of Sichuan Province, Key Laboratory of Bio-resources and 
      Eco-environment of Ministry of Education, Sichuan University, Chengdu, PR China.
FAU - Ge, Mengyun
AU  - Ge M
AD  - College of Life Sciences, Animal Disease Prevention and Food Safety Key 
      Laboratory of Sichuan Province, Key Laboratory of Bio-resources and 
      Eco-environment of Ministry of Education, Sichuan University, Chengdu, PR China.
FAU - Pan, Yun
AU  - Pan Y
AD  - College of Life Sciences, Animal Disease Prevention and Food Safety Key 
      Laboratory of Sichuan Province, Key Laboratory of Bio-resources and 
      Eco-environment of Ministry of Education, Sichuan University, Chengdu, PR China.
FAU - Li, Qingzhou
AU  - Li Q
AD  - College of Life Sciences, Animal Disease Prevention and Food Safety Key 
      Laboratory of Sichuan Province, Key Laboratory of Bio-resources and 
      Eco-environment of Ministry of Education, Sichuan University, Chengdu, PR China.
FAU - Wang, Hongning
AU  - Wang H
AD  - College of Life Sciences, Animal Disease Prevention and Food Safety Key 
      Laboratory of Sichuan Province, Key Laboratory of Bio-resources and 
      Eco-environment of Ministry of Education, Sichuan University, Chengdu, PR China. 
      Electronic address: whongning@163.com.
FAU - Zeng, Fanya
AU  - Zeng F
AD  - College of Life Sciences, Animal Disease Prevention and Food Safety Key 
      Laboratory of Sichuan Province, Key Laboratory of Bio-resources and 
      Eco-environment of Ministry of Education, Sichuan University, Chengdu, PR China. 
      Electronic address: zengfanya@scu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151130
PL  - Netherlands
TA  - Vet Microbiol
JT  - Veterinary microbiology
JID - 7705469
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Body Temperature
MH  - Breeding
MH  - Cytokines/genetics
MH  - Gene Expression Regulation/immunology
MH  - *Genetic Predisposition to Disease
MH  - Porcine Reproductive and Respiratory Syndrome/*genetics/mortality/pathology
MH  - Porcine respiratory and reproductive syndrome virus/*physiology
MH  - Swine/*classification/*genetics
MH  - Viral Load
MH  - Weight Gain
OTO - NOTNLM
OT  - Challenge
OT  - Highly pathogenic porcine reproductive and respiratory syndrome virus
OT  - Host susceptibility
OT  - Sus scrofa
OT  - Tibetan pig
EDAT- 2016/01/23 06:00
MHDA- 2016/10/16 06:00
CRDT- 2016/01/22 06:00
PHST- 2015/06/22 00:00 [received]
PHST- 2015/11/26 00:00 [revised]
PHST- 2015/11/27 00:00 [accepted]
PHST- 2016/01/22 06:00 [entrez]
PHST- 2016/01/23 06:00 [pubmed]
PHST- 2016/10/16 06:00 [medline]
AID - S0378-1135(15)30105-X [pii]
AID - 10.1016/j.vetmic.2015.11.035 [doi]
PST - ppublish
SO  - Vet Microbiol. 2016 Feb 1;183:62-8. doi: 10.1016/j.vetmic.2015.11.035. Epub 2015 
      Nov 30.